Pulmonary Nodules After Leflunomide Therapy in Rheumatoid Arthritis: A Case Report
ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disorder with both articular and extra‐articular manifestations, including rare pulmonary complications. We report a case of a 65‐year‐old male with long‐standing RA who developed multiple cavitary pulmonary nodules following prolonged lefl...
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| Format: | Article |
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Wiley
2025-01-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.9615 |
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| author | Mahdiye Abiyarghamsari Arman Ahmadzadeh |
| author_facet | Mahdiye Abiyarghamsari Arman Ahmadzadeh |
| author_sort | Mahdiye Abiyarghamsari |
| collection | DOAJ |
| description | ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disorder with both articular and extra‐articular manifestations, including rare pulmonary complications. We report a case of a 65‐year‐old male with long‐standing RA who developed multiple cavitary pulmonary nodules following prolonged leflunomide therapy. Diagnostic evaluation excluded infectious, neoplastic, and autoimmune causes. Bronchoscopy and biopsy confirmed an acute suppurative inflammatory process with central necrosis. Discontinuation of leflunomide resulted in the resolution of pulmonary nodules. This case highlights the need for vigilance regarding potential pulmonary toxicity in RA patients receiving leflunomide and underscores the importance of prompt recognition and management of drug‐induced complications. |
| format | Article |
| id | doaj-art-f6ee20da92844731bbe575a504d2fac5 |
| institution | Kabale University |
| issn | 2050-0904 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj-art-f6ee20da92844731bbe575a504d2fac52025-01-24T05:08:45ZengWileyClinical Case Reports2050-09042025-01-01131n/an/a10.1002/ccr3.9615Pulmonary Nodules After Leflunomide Therapy in Rheumatoid Arthritis: A Case ReportMahdiye Abiyarghamsari0Arman Ahmadzadeh1Department of Clinical Pharmacy, School of Pharmacy Shahid Beheshti University of Medical Sciences Tehran IranDepartment of Rheumatology Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences Tehran IranABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disorder with both articular and extra‐articular manifestations, including rare pulmonary complications. We report a case of a 65‐year‐old male with long‐standing RA who developed multiple cavitary pulmonary nodules following prolonged leflunomide therapy. Diagnostic evaluation excluded infectious, neoplastic, and autoimmune causes. Bronchoscopy and biopsy confirmed an acute suppurative inflammatory process with central necrosis. Discontinuation of leflunomide resulted in the resolution of pulmonary nodules. This case highlights the need for vigilance regarding potential pulmonary toxicity in RA patients receiving leflunomide and underscores the importance of prompt recognition and management of drug‐induced complications.https://doi.org/10.1002/ccr3.9615leflunomidenodulespulmonaryrheumatoid arthritis |
| spellingShingle | Mahdiye Abiyarghamsari Arman Ahmadzadeh Pulmonary Nodules After Leflunomide Therapy in Rheumatoid Arthritis: A Case Report Clinical Case Reports leflunomide nodules pulmonary rheumatoid arthritis |
| title | Pulmonary Nodules After Leflunomide Therapy in Rheumatoid Arthritis: A Case Report |
| title_full | Pulmonary Nodules After Leflunomide Therapy in Rheumatoid Arthritis: A Case Report |
| title_fullStr | Pulmonary Nodules After Leflunomide Therapy in Rheumatoid Arthritis: A Case Report |
| title_full_unstemmed | Pulmonary Nodules After Leflunomide Therapy in Rheumatoid Arthritis: A Case Report |
| title_short | Pulmonary Nodules After Leflunomide Therapy in Rheumatoid Arthritis: A Case Report |
| title_sort | pulmonary nodules after leflunomide therapy in rheumatoid arthritis a case report |
| topic | leflunomide nodules pulmonary rheumatoid arthritis |
| url | https://doi.org/10.1002/ccr3.9615 |
| work_keys_str_mv | AT mahdiyeabiyarghamsari pulmonarynodulesafterleflunomidetherapyinrheumatoidarthritisacasereport AT armanahmadzadeh pulmonarynodulesafterleflunomidetherapyinrheumatoidarthritisacasereport |