Bottom-up construction of chiral metal-peptide assemblies from metal cluster motifs
Abstract The exploration of artificial metal-peptide assemblies (MPAs) is one of the most exciting fields because of their great potential for simulating the dynamics and functionality of natural proteins. However, unfavorable enthalpy changes make forming discrete complexes with large and adaptable...
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| Format: | Article |
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Nature Portfolio
2024-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-53320-3 |
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| author | Pei-Ming Cheng Tao Jia Chong-Yang Li Ming-Qiang Qi Ming-Hao Du Hai-Feng Su Qing-Fu Sun La-Sheng Long Lan-Sun Zheng Xiang-Jian Kong |
| author_facet | Pei-Ming Cheng Tao Jia Chong-Yang Li Ming-Qiang Qi Ming-Hao Du Hai-Feng Su Qing-Fu Sun La-Sheng Long Lan-Sun Zheng Xiang-Jian Kong |
| author_sort | Pei-Ming Cheng |
| collection | DOAJ |
| description | Abstract The exploration of artificial metal-peptide assemblies (MPAs) is one of the most exciting fields because of their great potential for simulating the dynamics and functionality of natural proteins. However, unfavorable enthalpy changes make forming discrete complexes with large and adaptable cavities from flexible peptide ligands challenging. Here, we present a strategy integrating metal-cluster building blocks and peptides to create chiral metal-peptide assemblies and get a family of enantiopure [R-/S-Ni3L2]n (n = 2, 3, 6) MPAs, including the R-/S-Ni6L4 capsule, the S-Ni9L6 trigonal prism, and the R-/S-Ni18L12 octahedron cage. X-ray crystallography shows MPA formation reactions are highly solvent-condition-dependent, resulting in significant changes in ligand conformation and discrete cavity sizes. Moreover, we demonstrate that a structure transformation from Ni18L12 to Ni9L6 in the presence of benzopyrone molecules depends on the peptide conformational selection in crystallization. This work reveals that a metal-cluster building block approach enables facile bottom-up construction of artificial metal-peptide assemblies. |
| format | Article |
| id | doaj-art-f6e9ea091f9144e7a393394385c57c7c |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-f6e9ea091f9144e7a393394385c57c7c2025-08-20T02:17:50ZengNature PortfolioNature Communications2041-17232024-10-011511810.1038/s41467-024-53320-3Bottom-up construction of chiral metal-peptide assemblies from metal cluster motifsPei-Ming Cheng0Tao Jia1Chong-Yang Li2Ming-Qiang Qi3Ming-Hao Du4Hai-Feng Su5Qing-Fu Sun6La-Sheng Long7Lan-Sun Zheng8Xiang-Jian Kong9Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen UniversityCollaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen UniversityCollaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen UniversityCollaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen UniversityCollaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen UniversityCollaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen UniversityState Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of SciencesCollaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen UniversityCollaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen UniversityCollaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen UniversityAbstract The exploration of artificial metal-peptide assemblies (MPAs) is one of the most exciting fields because of their great potential for simulating the dynamics and functionality of natural proteins. However, unfavorable enthalpy changes make forming discrete complexes with large and adaptable cavities from flexible peptide ligands challenging. Here, we present a strategy integrating metal-cluster building blocks and peptides to create chiral metal-peptide assemblies and get a family of enantiopure [R-/S-Ni3L2]n (n = 2, 3, 6) MPAs, including the R-/S-Ni6L4 capsule, the S-Ni9L6 trigonal prism, and the R-/S-Ni18L12 octahedron cage. X-ray crystallography shows MPA formation reactions are highly solvent-condition-dependent, resulting in significant changes in ligand conformation and discrete cavity sizes. Moreover, we demonstrate that a structure transformation from Ni18L12 to Ni9L6 in the presence of benzopyrone molecules depends on the peptide conformational selection in crystallization. This work reveals that a metal-cluster building block approach enables facile bottom-up construction of artificial metal-peptide assemblies.https://doi.org/10.1038/s41467-024-53320-3 |
| spellingShingle | Pei-Ming Cheng Tao Jia Chong-Yang Li Ming-Qiang Qi Ming-Hao Du Hai-Feng Su Qing-Fu Sun La-Sheng Long Lan-Sun Zheng Xiang-Jian Kong Bottom-up construction of chiral metal-peptide assemblies from metal cluster motifs Nature Communications |
| title | Bottom-up construction of chiral metal-peptide assemblies from metal cluster motifs |
| title_full | Bottom-up construction of chiral metal-peptide assemblies from metal cluster motifs |
| title_fullStr | Bottom-up construction of chiral metal-peptide assemblies from metal cluster motifs |
| title_full_unstemmed | Bottom-up construction of chiral metal-peptide assemblies from metal cluster motifs |
| title_short | Bottom-up construction of chiral metal-peptide assemblies from metal cluster motifs |
| title_sort | bottom up construction of chiral metal peptide assemblies from metal cluster motifs |
| url | https://doi.org/10.1038/s41467-024-53320-3 |
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