Emerging immune checkpoint inhibitors for the treatment of oropharyngeal squamous cell carcinoma
Oropharyngeal Squamous Cell Carcinoma (OPSCC) is a challenging subtype of head and neck cancer that traditionally has been associated with poor prognosis and high morbidity due to the limitations of conventional treatments such as surgery, radiation, and chemotherapy. Immune checkpoint inhibitors ha...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024004965 |
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| author | Pandiselvi Ravi Shyamaladevi Babu |
| author_facet | Pandiselvi Ravi Shyamaladevi Babu |
| author_sort | Pandiselvi Ravi |
| collection | DOAJ |
| description | Oropharyngeal Squamous Cell Carcinoma (OPSCC) is a challenging subtype of head and neck cancer that traditionally has been associated with poor prognosis and high morbidity due to the limitations of conventional treatments such as surgery, radiation, and chemotherapy. Immune checkpoint inhibitors have revolutionized OPSCC and other cancer therapies. ICIs that target the PD-1 and PD-L1 axis and CTLA-4 have altered cancer action by improving the immune system capacity to detect and kill cancer cells. This paper discusses the significant impact of ICIs like Pembrolizumab and Nivolumab, which have been approved for use in recurrent or metastatic OPSCC and have demonstrated remarkable efficacy in clinical trials. The integration of these therapies into clinical practice has been facilitated by the identification of biomarkers such as PD-L1 expression, which guides personalized treatment strategies. Moreover, ongoing research into combination therapies involving ICIs and other treatment modalities is poised which, leads for further improvement in patient outcomes. Despite the successes, challenges such as immune-related adverse events and resistance mechanisms remain, underscoring the need for continued innovation and exploration in the field. This review highlights the pivotal role of ICIs in redefining OPSCC treatment, offering new hope for sustained survival and improved quality of life. |
| format | Article |
| id | doaj-art-f6e3bfde1f8b4e4e81bbe213ebfcc0ea |
| institution | OA Journals |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-f6e3bfde1f8b4e4e81bbe213ebfcc0ea2025-08-20T02:19:38ZengElsevierOral Oncology Reports2772-90602024-12-011210065010.1016/j.oor.2024.100650Emerging immune checkpoint inhibitors for the treatment of oropharyngeal squamous cell carcinomaPandiselvi Ravi0Shyamaladevi Babu1Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, 603103, Tamil Nadu, IndiaFaculty of Research, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, 603103, Tamil Nadu, India; Corresponding author.Oropharyngeal Squamous Cell Carcinoma (OPSCC) is a challenging subtype of head and neck cancer that traditionally has been associated with poor prognosis and high morbidity due to the limitations of conventional treatments such as surgery, radiation, and chemotherapy. Immune checkpoint inhibitors have revolutionized OPSCC and other cancer therapies. ICIs that target the PD-1 and PD-L1 axis and CTLA-4 have altered cancer action by improving the immune system capacity to detect and kill cancer cells. This paper discusses the significant impact of ICIs like Pembrolizumab and Nivolumab, which have been approved for use in recurrent or metastatic OPSCC and have demonstrated remarkable efficacy in clinical trials. The integration of these therapies into clinical practice has been facilitated by the identification of biomarkers such as PD-L1 expression, which guides personalized treatment strategies. Moreover, ongoing research into combination therapies involving ICIs and other treatment modalities is poised which, leads for further improvement in patient outcomes. Despite the successes, challenges such as immune-related adverse events and resistance mechanisms remain, underscoring the need for continued innovation and exploration in the field. This review highlights the pivotal role of ICIs in redefining OPSCC treatment, offering new hope for sustained survival and improved quality of life.http://www.sciencedirect.com/science/article/pii/S2772906024004965Oropharyngeal squamous cell carcinomaImmune checkpointsInhibitorsPD-1/PDL-1CTLA-4Pembrolizumab and nivolumab |
| spellingShingle | Pandiselvi Ravi Shyamaladevi Babu Emerging immune checkpoint inhibitors for the treatment of oropharyngeal squamous cell carcinoma Oral Oncology Reports Oropharyngeal squamous cell carcinoma Immune checkpoints Inhibitors PD-1/PDL-1 CTLA-4 Pembrolizumab and nivolumab |
| title | Emerging immune checkpoint inhibitors for the treatment of oropharyngeal squamous cell carcinoma |
| title_full | Emerging immune checkpoint inhibitors for the treatment of oropharyngeal squamous cell carcinoma |
| title_fullStr | Emerging immune checkpoint inhibitors for the treatment of oropharyngeal squamous cell carcinoma |
| title_full_unstemmed | Emerging immune checkpoint inhibitors for the treatment of oropharyngeal squamous cell carcinoma |
| title_short | Emerging immune checkpoint inhibitors for the treatment of oropharyngeal squamous cell carcinoma |
| title_sort | emerging immune checkpoint inhibitors for the treatment of oropharyngeal squamous cell carcinoma |
| topic | Oropharyngeal squamous cell carcinoma Immune checkpoints Inhibitors PD-1/PDL-1 CTLA-4 Pembrolizumab and nivolumab |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024004965 |
| work_keys_str_mv | AT pandiselviravi emergingimmunecheckpointinhibitorsforthetreatmentoforopharyngealsquamouscellcarcinoma AT shyamaladevibabu emergingimmunecheckpointinhibitorsforthetreatmentoforopharyngealsquamouscellcarcinoma |