Effects of Propofol versus Sevoflurane on Postoperative Pain and Neuroendocrine Stress Response in Oocyte Pickup Patients
Background. Pain aggravates the autonomic response to stress and raises neuroendocrine stress hormone levels. We compared the effects of propofol and sevoflurane on postoperative pain and neuroendocrine stress hormones. A prospective, randomized, and controlled trial was conducted with 60 patients....
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2021/5517150 |
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| author | Yavuz Orak Fatma İnanç Tolun Murat Bakacak Aslı Yaylalı Hakan Kıran Hafize Öksüz Adem Doğaner Işıl Yağmur Ahmet Altun |
| author_facet | Yavuz Orak Fatma İnanç Tolun Murat Bakacak Aslı Yaylalı Hakan Kıran Hafize Öksüz Adem Doğaner Işıl Yağmur Ahmet Altun |
| author_sort | Yavuz Orak |
| collection | DOAJ |
| description | Background. Pain aggravates the autonomic response to stress and raises neuroendocrine stress hormone levels. We compared the effects of propofol and sevoflurane on postoperative pain and neuroendocrine stress hormones. A prospective, randomized, and controlled trial was conducted with 60 patients. Methods. We randomly allocated patients to groups P (remifentanil/propofol, n = 30) and S (remifentanil/sevoflurane, n = 30). Preoperative blood samples were taken to measure serum adrenocorticotropic hormone (ACTH), corticotropin-releasing hormone (CRH), glucagon, cortisol, aldosterone, and prostaglandin E2 (PGE2) levels. Intraoperatively and postoperatively, clinical parameters were monitored at different time points. The hormone levels were again measured in the follicular fluid and blood postoperatively. Result. Demographic data were similar. The preoperative serum aldosterone levels were significantly higher in group P (p=0.001). Preoperative and postoperative serum ACTH, glucagon, cortisol, and PGE2 levels were significantly different in group P (p=0.009, p=0.004, p=0.029, and p=0.002); serum ACTH, glucagon, and PGE2 levels increased while serum cortisol levels decreased postoperatively. In group S, serum CRH and aldosterone levels, both increased in the postoperative period compared to the preoperative (p=0.001, p=0.006). Postoperatively, glucagon and PGE2 levels were both higher in group P than group S (p=0.019, p=0.015). In postoperative follicular fluid, glucagon and PGE2 levels were higher in group P, while cortisol levels were higher in group S (p=0.001, p=0.007, and p=0.001). Conclusion. The effects of anesthetic agents were different. In group P, in the preoperative and postoperative evaluation, ACTH, glucagon, and PGE2 increased postoperatively, while cortisol decreased. In group S, aldosterone and CRH increased postoperatively. Glucagon and PG E2 were higher in group P than S, postoperatively. |
| format | Article |
| id | doaj-art-f6d3622415334b729368f0b3d7c41b66 |
| institution | Kabale University |
| issn | 1203-6765 1918-1523 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-f6d3622415334b729368f0b3d7c41b662025-02-03T00:58:50ZengWileyPain Research and Management1203-67651918-15232021-01-01202110.1155/2021/55171505517150Effects of Propofol versus Sevoflurane on Postoperative Pain and Neuroendocrine Stress Response in Oocyte Pickup PatientsYavuz Orak0Fatma İnanç Tolun1Murat Bakacak2Aslı Yaylalı3Hakan Kıran4Hafize Öksüz5Adem Doğaner6Işıl Yağmur7Ahmet Altun8Department of Anesthesiology and Reanimation, Kahramanmaras Sutcu Imam University, Kahramanmaras, TurkeyDepartment of Biochemistry, Kahramanmaras Sutcu Imam University, Kahramanmaras, TurkeyDepartment of Obstetrics and Gynecology, Kahramanmaras Sutcu Imam University, Kahramanmaras, TurkeyHistology Department, Kahramanmaras Sutcu Imam University, Kahramanmaras, TurkeyDepartment of Obstetrics and Gynecology, Kahramanmaras Sutcu Imam University, Kahramanmaras, TurkeyDepartment of Anesthesiology and Reanimation, Kahramanmaras Sutcu Imam University, Kahramanmaras, TurkeyBiostatistics and Medical Informatics, Kahramanmaras Sutcu Imam University, Kahramanmaras, TurkeyDepartment of Biochemistry, Kahramanmaras Sutcu Imam University, Kahramanmaras, TurkeyDepartment of Pharmacology, Sivas Cumhuriyet University, Sivas, TurkeyBackground. Pain aggravates the autonomic response to stress and raises neuroendocrine stress hormone levels. We compared the effects of propofol and sevoflurane on postoperative pain and neuroendocrine stress hormones. A prospective, randomized, and controlled trial was conducted with 60 patients. Methods. We randomly allocated patients to groups P (remifentanil/propofol, n = 30) and S (remifentanil/sevoflurane, n = 30). Preoperative blood samples were taken to measure serum adrenocorticotropic hormone (ACTH), corticotropin-releasing hormone (CRH), glucagon, cortisol, aldosterone, and prostaglandin E2 (PGE2) levels. Intraoperatively and postoperatively, clinical parameters were monitored at different time points. The hormone levels were again measured in the follicular fluid and blood postoperatively. Result. Demographic data were similar. The preoperative serum aldosterone levels were significantly higher in group P (p=0.001). Preoperative and postoperative serum ACTH, glucagon, cortisol, and PGE2 levels were significantly different in group P (p=0.009, p=0.004, p=0.029, and p=0.002); serum ACTH, glucagon, and PGE2 levels increased while serum cortisol levels decreased postoperatively. In group S, serum CRH and aldosterone levels, both increased in the postoperative period compared to the preoperative (p=0.001, p=0.006). Postoperatively, glucagon and PGE2 levels were both higher in group P than group S (p=0.019, p=0.015). In postoperative follicular fluid, glucagon and PGE2 levels were higher in group P, while cortisol levels were higher in group S (p=0.001, p=0.007, and p=0.001). Conclusion. The effects of anesthetic agents were different. In group P, in the preoperative and postoperative evaluation, ACTH, glucagon, and PGE2 increased postoperatively, while cortisol decreased. In group S, aldosterone and CRH increased postoperatively. Glucagon and PG E2 were higher in group P than S, postoperatively.http://dx.doi.org/10.1155/2021/5517150 |
| spellingShingle | Yavuz Orak Fatma İnanç Tolun Murat Bakacak Aslı Yaylalı Hakan Kıran Hafize Öksüz Adem Doğaner Işıl Yağmur Ahmet Altun Effects of Propofol versus Sevoflurane on Postoperative Pain and Neuroendocrine Stress Response in Oocyte Pickup Patients Pain Research and Management |
| title | Effects of Propofol versus Sevoflurane on Postoperative Pain and Neuroendocrine Stress Response in Oocyte Pickup Patients |
| title_full | Effects of Propofol versus Sevoflurane on Postoperative Pain and Neuroendocrine Stress Response in Oocyte Pickup Patients |
| title_fullStr | Effects of Propofol versus Sevoflurane on Postoperative Pain and Neuroendocrine Stress Response in Oocyte Pickup Patients |
| title_full_unstemmed | Effects of Propofol versus Sevoflurane on Postoperative Pain and Neuroendocrine Stress Response in Oocyte Pickup Patients |
| title_short | Effects of Propofol versus Sevoflurane on Postoperative Pain and Neuroendocrine Stress Response in Oocyte Pickup Patients |
| title_sort | effects of propofol versus sevoflurane on postoperative pain and neuroendocrine stress response in oocyte pickup patients |
| url | http://dx.doi.org/10.1155/2021/5517150 |
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