Programmable probiotic consortium employ an oleic acid-inducible system to sense and degrade cholesterol in high-fat diet mice

Programmable probiotic consortium employ an oleic acid-inducible system to sense and degrade cholesterol in high-fat diet mice

High cholesterol is a major risk factor for cardiovascular disease (CVD), and current treatment strategies primarily focus on inhibiting cholesterol synthesis and reducing cholesterol absorption. Engineered synthetic consortia are emerging as a promising alternative for lowering cholesterol level an...

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Bibliographic Details
Main Authors: Qi Yang, Wei Xiang, Aman Khan, El-Sayed Salama, Sourabh Kulshreshtha, Jing Ji, Ying Wu, Xiangkai Li
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gut Microbes
Subjects:
Synthetic biology
engineered probiotics
cholesterol
high-fat diet
lipid metabolism
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2025.2531198
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