Relationship between Serum Cytokeratin-18, Control Attenuation Parameter, NAFLD Fibrosis Score, and Liver Steatosis in Nonalcoholic Fatty Liver Disease
Backgrounds. The aim of this study was to appraise the relationship between serum fragmented cytokeratin-18(CK-18), controlled attenuation parameter (CAP), and liver steatosis assessed by ultrasound (US) in nonalcoholic fatty liver disease (NAFLD) patients. Methods. Patients who underwent abdominal...
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| Language: | English |
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2018-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2018/9252536 |
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| author | Sumitro Kosasih Wong Zhi Qin Rafiz Abdul Rani Nazefah Abd Hamid Ngiu Chai Soon Shamsul Azhar Shah Yazmin Yaakob Raja Affendi Raja Ali |
| author_facet | Sumitro Kosasih Wong Zhi Qin Rafiz Abdul Rani Nazefah Abd Hamid Ngiu Chai Soon Shamsul Azhar Shah Yazmin Yaakob Raja Affendi Raja Ali |
| author_sort | Sumitro Kosasih |
| collection | DOAJ |
| description | Backgrounds. The aim of this study was to appraise the relationship between serum fragmented cytokeratin-18(CK-18), controlled attenuation parameter (CAP), and liver steatosis assessed by ultrasound (US) in nonalcoholic fatty liver disease (NAFLD) patients. Methods. Patients who underwent abdominal US were recruited, followed with measurement of CAP using Fibroscan® and serum fragmented CK-18 using enzyme-linked immunosorbent assay. The degree of liver steatosis assessed by US was categorized into mild (S1), moderate (S2), and severe (S3). Results. A total of 109 patients were included in our study. CAP and fragmented CK-18 level were significantly correlated with liver steatosis grade with rs = 0.56 and 0.68, p=0.001, respectively. NAFLD Fibrosis Score was poorly correlated with liver steatosis grade (rs=-0.096, p=0.318). Using fragmented CK-18 level, area under receiver operating characteristic (AUROC) curves for S≥2 and S≥3 were excellent (0.82 and 0.84, respectively). Using CAP, AUROC curves for detection of S≥2 and S≥3 were good (0.76, 0.77, respectively). We also proposed cut-off value of CAP to detect S≥2 and S≥3 to be 263 and 319db/m, respectively, and fragmented CK-18 level to detect S≥2 and S≥3 (194 and 294 U/L, respectively). Conclusions. Both the fragmented CK-18 level and the CAP, but not NAFLD Fibrosis Score, were well correlated with hepatic steatosis grade as assessed by US. |
| format | Article |
| id | doaj-art-f6c0b180317a48fba427a643ead058e9 |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-f6c0b180317a48fba427a643ead058e92025-02-03T05:50:45ZengWileyInternational Journal of Hepatology2090-34482090-34562018-01-01201810.1155/2018/92525369252536Relationship between Serum Cytokeratin-18, Control Attenuation Parameter, NAFLD Fibrosis Score, and Liver Steatosis in Nonalcoholic Fatty Liver DiseaseSumitro Kosasih0Wong Zhi Qin1Rafiz Abdul Rani2Nazefah Abd Hamid3Ngiu Chai Soon4Shamsul Azhar Shah5Yazmin Yaakob6Raja Affendi Raja Ali7Gastroenterology and Hepatology Unit, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, 56000, MalaysiaGastroenterology and Hepatology Unit, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, 56000, MalaysiaGastroenterology Unit, Faculty of Medicine, Universiti Teknologi MARA, Shah Alam, Selangor, 40450, MalaysiaDepartment of Medical and Health Science, Universiti Sains Islam Malaysia, Nilai, Negeri Sembilan, 71800, MalaysiaGastroenterology and Hepatology Unit, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, 56000, MalaysiaDepartment of Public Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, 56000, MalaysiaDepartment of Radiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, 56000, MalaysiaGastroenterology and Hepatology Unit, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, 56000, MalaysiaBackgrounds. The aim of this study was to appraise the relationship between serum fragmented cytokeratin-18(CK-18), controlled attenuation parameter (CAP), and liver steatosis assessed by ultrasound (US) in nonalcoholic fatty liver disease (NAFLD) patients. Methods. Patients who underwent abdominal US were recruited, followed with measurement of CAP using Fibroscan® and serum fragmented CK-18 using enzyme-linked immunosorbent assay. The degree of liver steatosis assessed by US was categorized into mild (S1), moderate (S2), and severe (S3). Results. A total of 109 patients were included in our study. CAP and fragmented CK-18 level were significantly correlated with liver steatosis grade with rs = 0.56 and 0.68, p=0.001, respectively. NAFLD Fibrosis Score was poorly correlated with liver steatosis grade (rs=-0.096, p=0.318). Using fragmented CK-18 level, area under receiver operating characteristic (AUROC) curves for S≥2 and S≥3 were excellent (0.82 and 0.84, respectively). Using CAP, AUROC curves for detection of S≥2 and S≥3 were good (0.76, 0.77, respectively). We also proposed cut-off value of CAP to detect S≥2 and S≥3 to be 263 and 319db/m, respectively, and fragmented CK-18 level to detect S≥2 and S≥3 (194 and 294 U/L, respectively). Conclusions. Both the fragmented CK-18 level and the CAP, but not NAFLD Fibrosis Score, were well correlated with hepatic steatosis grade as assessed by US.http://dx.doi.org/10.1155/2018/9252536 |
| spellingShingle | Sumitro Kosasih Wong Zhi Qin Rafiz Abdul Rani Nazefah Abd Hamid Ngiu Chai Soon Shamsul Azhar Shah Yazmin Yaakob Raja Affendi Raja Ali Relationship between Serum Cytokeratin-18, Control Attenuation Parameter, NAFLD Fibrosis Score, and Liver Steatosis in Nonalcoholic Fatty Liver Disease International Journal of Hepatology |
| title | Relationship between Serum Cytokeratin-18, Control Attenuation Parameter, NAFLD Fibrosis Score, and Liver Steatosis in Nonalcoholic Fatty Liver Disease |
| title_full | Relationship between Serum Cytokeratin-18, Control Attenuation Parameter, NAFLD Fibrosis Score, and Liver Steatosis in Nonalcoholic Fatty Liver Disease |
| title_fullStr | Relationship between Serum Cytokeratin-18, Control Attenuation Parameter, NAFLD Fibrosis Score, and Liver Steatosis in Nonalcoholic Fatty Liver Disease |
| title_full_unstemmed | Relationship between Serum Cytokeratin-18, Control Attenuation Parameter, NAFLD Fibrosis Score, and Liver Steatosis in Nonalcoholic Fatty Liver Disease |
| title_short | Relationship between Serum Cytokeratin-18, Control Attenuation Parameter, NAFLD Fibrosis Score, and Liver Steatosis in Nonalcoholic Fatty Liver Disease |
| title_sort | relationship between serum cytokeratin 18 control attenuation parameter nafld fibrosis score and liver steatosis in nonalcoholic fatty liver disease |
| url | http://dx.doi.org/10.1155/2018/9252536 |
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