Myeloid ACAT1/SOAT1: a novel regulator of dyslipidemia and retinal neovascularization
Abstract Pathological retinal neovascularization (RNV) is a major cause of vision loss and blindness during ischemic retinopathies. Our investigations in the mouse model of oxygen-induced retinopathy (OIR) demonstrate a novel mechanism of pathological RNV and neurovascular injury. We show that OIR-i...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Metabolic Health and Disease |
| Online Access: | https://doi.org/10.1038/s44324-024-00046-x |
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| author | Syed A. H. Zaidi Ruth B. Caldwell Modesto A. Rojas |
| author_facet | Syed A. H. Zaidi Ruth B. Caldwell Modesto A. Rojas |
| author_sort | Syed A. H. Zaidi |
| collection | DOAJ |
| description | Abstract Pathological retinal neovascularization (RNV) is a major cause of vision loss and blindness during ischemic retinopathies. Our investigations in the mouse model of oxygen-induced retinopathy (OIR) demonstrate a novel mechanism of pathological RNV and neurovascular injury. We show that OIR-induced activation of macrophage/microglial cells, retinal inflammation, and pathological RNV are mediated by increases in cholesterol ester (CE) formation due to activation of the acyl-CoA: Cholesterol Acyltransferase 1/Sterol O-Acyltransferase 1 (ACAT1/SOAT1) enzyme. |
| format | Article |
| id | doaj-art-f6b49136966546abb100d320a7b20745 |
| institution | Kabale University |
| issn | 2948-2828 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Metabolic Health and Disease |
| spelling | doaj-art-f6b49136966546abb100d320a7b207452025-01-19T12:10:10ZengNature Portfolionpj Metabolic Health and Disease2948-28282025-01-01311610.1038/s44324-024-00046-xMyeloid ACAT1/SOAT1: a novel regulator of dyslipidemia and retinal neovascularizationSyed A. H. Zaidi0Ruth B. Caldwell1Modesto A. Rojas2Vascular Biology Center, Augusta UniversityVascular Biology Center, Augusta UniversityVascular Biology Center, Augusta UniversityAbstract Pathological retinal neovascularization (RNV) is a major cause of vision loss and blindness during ischemic retinopathies. Our investigations in the mouse model of oxygen-induced retinopathy (OIR) demonstrate a novel mechanism of pathological RNV and neurovascular injury. We show that OIR-induced activation of macrophage/microglial cells, retinal inflammation, and pathological RNV are mediated by increases in cholesterol ester (CE) formation due to activation of the acyl-CoA: Cholesterol Acyltransferase 1/Sterol O-Acyltransferase 1 (ACAT1/SOAT1) enzyme.https://doi.org/10.1038/s44324-024-00046-x |
| spellingShingle | Syed A. H. Zaidi Ruth B. Caldwell Modesto A. Rojas Myeloid ACAT1/SOAT1: a novel regulator of dyslipidemia and retinal neovascularization npj Metabolic Health and Disease |
| title | Myeloid ACAT1/SOAT1: a novel regulator of dyslipidemia and retinal neovascularization |
| title_full | Myeloid ACAT1/SOAT1: a novel regulator of dyslipidemia and retinal neovascularization |
| title_fullStr | Myeloid ACAT1/SOAT1: a novel regulator of dyslipidemia and retinal neovascularization |
| title_full_unstemmed | Myeloid ACAT1/SOAT1: a novel regulator of dyslipidemia and retinal neovascularization |
| title_short | Myeloid ACAT1/SOAT1: a novel regulator of dyslipidemia and retinal neovascularization |
| title_sort | myeloid acat1 soat1 a novel regulator of dyslipidemia and retinal neovascularization |
| url | https://doi.org/10.1038/s44324-024-00046-x |
| work_keys_str_mv | AT syedahzaidi myeloidacat1soat1anovelregulatorofdyslipidemiaandretinalneovascularization AT ruthbcaldwell myeloidacat1soat1anovelregulatorofdyslipidemiaandretinalneovascularization AT modestoarojas myeloidacat1soat1anovelregulatorofdyslipidemiaandretinalneovascularization |