Apobec-mediated retroviral hypermutation in vivo is dependent on mouse strain.

Apobec-mediated retroviral hypermutation in vivo is dependent on mouse strain.

Replication of the complex retrovirus mouse mammary tumor virus (MMTV) is antagonized by murine Apobec3 (mA3), a member of the Apobec family of cytidine deaminases. We have shown that MMTV-encoded Rem protein inhibits proviral mutagenesis by the Apobec enzyme, activation-induced cytidine deaminase (...

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Bibliographic Details
Main Authors: Hyewon Byun, Gurvani B Singh, Wendy Kaichun Xu, Poulami Das, Alejandro Reyes, Anna Battenhouse, Dennis C Wylie, Mario L Santiago, Mary M Lozano, Jaquelin P Dudley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-08-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012505
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