The Impact of T Cell Vaccination in Alleviating and Regulating Systemic Lupus Erythematosus Manifestation
Objective. Systemic lupus erythematosus (SLE) is an autoimmune disease identified by a plethora of production of autoantibodies. Autoreactive T cells may play an important role in the process. Attenuated T cell vaccination (TCV) has proven to benefit some autoimmune diseases by deleting or suppressi...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/5183686 |
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| _version_ | 1832559458238070784 |
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| author | Liuye Huang Yuan Yang Yu Kuang Dapeng Wei Wanyi Li Qin Yin Juan Pang Zhongwei Zhang |
| author_facet | Liuye Huang Yuan Yang Yu Kuang Dapeng Wei Wanyi Li Qin Yin Juan Pang Zhongwei Zhang |
| author_sort | Liuye Huang |
| collection | DOAJ |
| description | Objective. Systemic lupus erythematosus (SLE) is an autoimmune disease identified by a plethora of production of autoantibodies. Autoreactive T cells may play an important role in the process. Attenuated T cell vaccination (TCV) has proven to benefit some autoimmune diseases by deleting or suppressing pathogenic T cells. However, clinical evidence for TCV in SLE is still limited. Therefore, this self-controlled study concentrates on the clinical effects of TCV on SLE patients. Methods. 16 patients were enrolled in the study; they accepted TCV regularly. SLEDAI, clinical symptoms, blood parameters including complements 3 and 4 levels, ANA, and anti-ds-DNA antibodies were tested. In addition, the side effects and drug usage were observed during the patients’ treatment and follow-up. Results. Remissions in clinical symptoms such as facial rash, vasculitis, and proteinuria were noted in most patients. There are also evident reductions in SLEDAI, anti-ds-DNA antibodies, and GC dose and increases in C3 and C4 levels, with no pathogenic side effects during treatment and follow-up. Conclusions. T cell vaccination is helpful in alleviating and regulating systemic lupus erythematosus manifestation. |
| format | Article |
| id | doaj-art-f6aecd66cb6a466c93fa7f5c4e9c2bf4 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-f6aecd66cb6a466c93fa7f5c4e9c2bf42025-02-03T01:30:08ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/51836865183686The Impact of T Cell Vaccination in Alleviating and Regulating Systemic Lupus Erythematosus ManifestationLiuye Huang0Yuan Yang1Yu Kuang2Dapeng Wei3Wanyi Li4Qin Yin5Juan Pang6Zhongwei Zhang7Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, ChinaDepartment of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, ChinaDepartment of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, ChinaDepartment of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, ChinaDepartment of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, ChinaDepartment of Rheumatology, Jinjiang District People’s Hospital of Chengdu City, Chengdu, ChinaWest China School of Public Health, No. 4 West China Teaching Hospital, Sichuan University, Chengdu, ChinaICU, West China Hospital, Sichuan University, Chengdu, ChinaObjective. Systemic lupus erythematosus (SLE) is an autoimmune disease identified by a plethora of production of autoantibodies. Autoreactive T cells may play an important role in the process. Attenuated T cell vaccination (TCV) has proven to benefit some autoimmune diseases by deleting or suppressing pathogenic T cells. However, clinical evidence for TCV in SLE is still limited. Therefore, this self-controlled study concentrates on the clinical effects of TCV on SLE patients. Methods. 16 patients were enrolled in the study; they accepted TCV regularly. SLEDAI, clinical symptoms, blood parameters including complements 3 and 4 levels, ANA, and anti-ds-DNA antibodies were tested. In addition, the side effects and drug usage were observed during the patients’ treatment and follow-up. Results. Remissions in clinical symptoms such as facial rash, vasculitis, and proteinuria were noted in most patients. There are also evident reductions in SLEDAI, anti-ds-DNA antibodies, and GC dose and increases in C3 and C4 levels, with no pathogenic side effects during treatment and follow-up. Conclusions. T cell vaccination is helpful in alleviating and regulating systemic lupus erythematosus manifestation.http://dx.doi.org/10.1155/2016/5183686 |
| spellingShingle | Liuye Huang Yuan Yang Yu Kuang Dapeng Wei Wanyi Li Qin Yin Juan Pang Zhongwei Zhang The Impact of T Cell Vaccination in Alleviating and Regulating Systemic Lupus Erythematosus Manifestation Journal of Immunology Research |
| title | The Impact of T Cell Vaccination in Alleviating and Regulating Systemic Lupus Erythematosus Manifestation |
| title_full | The Impact of T Cell Vaccination in Alleviating and Regulating Systemic Lupus Erythematosus Manifestation |
| title_fullStr | The Impact of T Cell Vaccination in Alleviating and Regulating Systemic Lupus Erythematosus Manifestation |
| title_full_unstemmed | The Impact of T Cell Vaccination in Alleviating and Regulating Systemic Lupus Erythematosus Manifestation |
| title_short | The Impact of T Cell Vaccination in Alleviating and Regulating Systemic Lupus Erythematosus Manifestation |
| title_sort | impact of t cell vaccination in alleviating and regulating systemic lupus erythematosus manifestation |
| url | http://dx.doi.org/10.1155/2016/5183686 |
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