A self-activated and protective module enhances the preclinical performance of allogeneic anti-CD70 CAR-T cells

A self-activated and protective module enhances the preclinical performance of allogeneic anti-CD70 CAR-T cells

IntroductionAllogeneic chimeric antigen receptor T (CAR-T) therapy, also known as universal CAR-T (UCAR-T) therapy, offers broad applicability, high production efficiency, and reduced costs, enabling quicker access for patients. However, clinical application remains limited by challenges such as imm...

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Bibliographic Details
Main Authors: Zhao Zhang, Lianfeng Zhao, Tinghui Huang, Zhengliang Chen, Yaoyao Zhao, Junqing Liang, Xudong Ao, Xiaoqiong Jia, Lei Kang, Linghui Kong, Qi Jing, Jianhua Hu, Lili Gu, Feiyan Pan, Zhigang Hu, Lingfeng He, Muya Zhou, Jiannan Chen, Zhigang Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
chimeric antigen receptor T (CAR-T)
allogeneic CAR-T
cancer immunotherapy
solid tumor
CD70-positive cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1531294/full
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