Methotrexate Induced Pancytopenia
The well-reported methotrexate (MTX) toxicities are based on the duration and cumulative dosing of drug. The typical toxicities can be predicted by the timing of drug administration, where mucositis occurs as an earlier effect, while myelosuppression and the sequelae of pancytopenia occur later afte...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2014/679580 |
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| author | Fernando Gonzalez-Ibarra Sahar Eivaz-Mohammadi Shiri Surapaneni Hazem Alsaadi Amer K. Syed Simon Badin Valentin Marian Mazhar Elamir |
| author_facet | Fernando Gonzalez-Ibarra Sahar Eivaz-Mohammadi Shiri Surapaneni Hazem Alsaadi Amer K. Syed Simon Badin Valentin Marian Mazhar Elamir |
| author_sort | Fernando Gonzalez-Ibarra |
| collection | DOAJ |
| description | The well-reported methotrexate (MTX) toxicities are based on the duration and cumulative dosing of drug. The typical toxicities can be predicted by the timing of drug administration, where mucositis occurs as an earlier effect, while myelosuppression and the sequelae of pancytopenia occur later after MTX administration. Despite these well-known toxicities, low dose MTX therapy can become problematic, in particular with the elderly, who are at a greater risk for significant myelosuppression. We present a case of a 73-year-old female with pancytopenia causing severe neutropenia, mucocutaneous bleeding, and bruising and requiring intravenous antibiotic therapy and limited transfusion dependence as a result of low dose daily MTX for rheumatoid arthritis. |
| format | Article |
| id | doaj-art-f6a1ac7762a049b79ebeaa628b3920b3 |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-f6a1ac7762a049b79ebeaa628b3920b32025-02-03T01:12:12ZengWileyCase Reports in Rheumatology2090-68892090-68972014-01-01201410.1155/2014/679580679580Methotrexate Induced PancytopeniaFernando Gonzalez-Ibarra0Sahar Eivaz-Mohammadi1Shiri Surapaneni2Hazem Alsaadi3Amer K. Syed4Simon Badin5Valentin Marian6Mazhar Elamir7Department of Internal Medicine, Mount Sinai School of Medicine, Jersey City Medical Center, 355 Grand Street, Jersey City, NJ 07302, USADepartment of Internal Medicine, Mount Sinai School of Medicine, Jersey City Medical Center, 355 Grand Street, Jersey City, NJ 07302, USADepartment of Internal Medicine, Mount Sinai School of Medicine, Jersey City Medical Center, 355 Grand Street, Jersey City, NJ 07302, USA Department of Internal Medicine, Jersey City Medical Center, St. George’s University School of Medicine, Jersey City, NJ 07302, USALaureate National Institute of Medicine, Jersey City Medical Center, 355 Grand Street, Jersey City, NJ 07302, USADepartment of Hematology, Mount Sinai School of Medicine, Jersey City Medical Center, Jersey City, NJ 07302, USADepartment of Rheumatology, Mount Sinai School of Medicine, Jersey City Medical Center, Jersey City, NJ 07302, USADepartment of Internal Medicine, Mount Sinai School of Medicine, Jersey City Medical Center, 355 Grand Street, Jersey City, NJ 07302, USAThe well-reported methotrexate (MTX) toxicities are based on the duration and cumulative dosing of drug. The typical toxicities can be predicted by the timing of drug administration, where mucositis occurs as an earlier effect, while myelosuppression and the sequelae of pancytopenia occur later after MTX administration. Despite these well-known toxicities, low dose MTX therapy can become problematic, in particular with the elderly, who are at a greater risk for significant myelosuppression. We present a case of a 73-year-old female with pancytopenia causing severe neutropenia, mucocutaneous bleeding, and bruising and requiring intravenous antibiotic therapy and limited transfusion dependence as a result of low dose daily MTX for rheumatoid arthritis.http://dx.doi.org/10.1155/2014/679580 |
| spellingShingle | Fernando Gonzalez-Ibarra Sahar Eivaz-Mohammadi Shiri Surapaneni Hazem Alsaadi Amer K. Syed Simon Badin Valentin Marian Mazhar Elamir Methotrexate Induced Pancytopenia Case Reports in Rheumatology |
| title | Methotrexate Induced Pancytopenia |
| title_full | Methotrexate Induced Pancytopenia |
| title_fullStr | Methotrexate Induced Pancytopenia |
| title_full_unstemmed | Methotrexate Induced Pancytopenia |
| title_short | Methotrexate Induced Pancytopenia |
| title_sort | methotrexate induced pancytopenia |
| url | http://dx.doi.org/10.1155/2014/679580 |
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