Risk factors for cardio-cerebrovascular events among patients undergoing continuous ambulatory peritoneal dialysis and their association with serum magnesium
Serum magnesium levels exceeding 0.9 mmol/L are associated with increased survival rates in patients with CKD. This retrospective study aimed to identify risk factors for cardio-cerebrovascular events among patients receiving continuous ambulatory peritoneal dialysis (CAPD) and to examine their corr...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2355354 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591138730541056 |
|---|---|
| author | Penglei Li Tiegang Lv Liping Xu Wenlu Yu Yuanyuan Lu Yuanyuan Li Jian Hao |
| author_facet | Penglei Li Tiegang Lv Liping Xu Wenlu Yu Yuanyuan Lu Yuanyuan Li Jian Hao |
| author_sort | Penglei Li |
| collection | DOAJ |
| description | Serum magnesium levels exceeding 0.9 mmol/L are associated with increased survival rates in patients with CKD. This retrospective study aimed to identify risk factors for cardio-cerebrovascular events among patients receiving continuous ambulatory peritoneal dialysis (CAPD) and to examine their correlations with serum magnesium levels. Sociodemographic data, clinical physiological and biochemical indexes, and cardio-cerebrovascular event data were collected from 189 patients undergoing CAPD. Risk factors associated with cardio-cerebrovascular events were identified by univariate binary logistic regression analysis. Correlations between the risk factors and serum magnesium levels were determined by correlation analysis. Univariate regression analysis identified age, C-reactive protein (CRP), red cell volume distribution width standard deviation, red cell volume distribution width corpuscular volume, serum albumin, serum potassium, serum sodium, serum chlorine, serum magnesium, and serum uric acid as risk factors for cardio-cerebrovascular events. Among them, serum magnesium ≤0.8 mmol/L had the highest odds ratio (3.996). Multivariate regression analysis revealed that serum magnesium was an independent risk factor, while serum UA (<440 μmol/L) was an independent protective factor for cardio-cerebrovascular events. The incidence of cardio-cerebrovascular events differed significantly among patients with different grades of serum magnesium (χ2 = 12.023, p = 0.002), with the highest incidence observed in patients with a serum magnesium concentration <0.8 mmol/L. High serum magnesium levels were correlated with high levels of serum albumin (r = 0.399, p < 0.001), serum potassium (r = 0.423, p < 0.001), and serum uric acid (r = 0.411, p < 0.001), and low levels of CRP (r = −0.279, p < 0.001). In conclusion, low serum magnesium may predict cardio-cerebrovascular events in patients receiving CAPD. |
| format | Article |
| id | doaj-art-f68f4b168da9419a8aee266fd00f392b |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-f68f4b168da9419a8aee266fd00f392b2025-01-23T04:17:48ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2355354Risk factors for cardio-cerebrovascular events among patients undergoing continuous ambulatory peritoneal dialysis and their association with serum magnesiumPenglei Li0Tiegang Lv1Liping Xu2Wenlu Yu3Yuanyuan Lu4Yuanyuan Li5Jian Hao6Department of Medicine, Division of Nephrology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, ChinaDepartment of Medicine, Division of Nephrology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, ChinaDepartment of Medicine, Division of Nephrology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, ChinaDepartment of Medicine, Division of Nephrology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, ChinaDepartment of Medicine, Division of Nephrology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, ChinaDepartment of Medicine, Division of Nephrology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, ChinaDepartment of Medicine, Division of Nephrology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, ChinaSerum magnesium levels exceeding 0.9 mmol/L are associated with increased survival rates in patients with CKD. This retrospective study aimed to identify risk factors for cardio-cerebrovascular events among patients receiving continuous ambulatory peritoneal dialysis (CAPD) and to examine their correlations with serum magnesium levels. Sociodemographic data, clinical physiological and biochemical indexes, and cardio-cerebrovascular event data were collected from 189 patients undergoing CAPD. Risk factors associated with cardio-cerebrovascular events were identified by univariate binary logistic regression analysis. Correlations between the risk factors and serum magnesium levels were determined by correlation analysis. Univariate regression analysis identified age, C-reactive protein (CRP), red cell volume distribution width standard deviation, red cell volume distribution width corpuscular volume, serum albumin, serum potassium, serum sodium, serum chlorine, serum magnesium, and serum uric acid as risk factors for cardio-cerebrovascular events. Among them, serum magnesium ≤0.8 mmol/L had the highest odds ratio (3.996). Multivariate regression analysis revealed that serum magnesium was an independent risk factor, while serum UA (<440 μmol/L) was an independent protective factor for cardio-cerebrovascular events. The incidence of cardio-cerebrovascular events differed significantly among patients with different grades of serum magnesium (χ2 = 12.023, p = 0.002), with the highest incidence observed in patients with a serum magnesium concentration <0.8 mmol/L. High serum magnesium levels were correlated with high levels of serum albumin (r = 0.399, p < 0.001), serum potassium (r = 0.423, p < 0.001), and serum uric acid (r = 0.411, p < 0.001), and low levels of CRP (r = −0.279, p < 0.001). In conclusion, low serum magnesium may predict cardio-cerebrovascular events in patients receiving CAPD.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2355354Chronic kidney disease (CKD)continuous ambulatory peritoneal dialysis (CAPD)magnesiumcardiovascular and cerebrovascular diseases (CVDs) |
| spellingShingle | Penglei Li Tiegang Lv Liping Xu Wenlu Yu Yuanyuan Lu Yuanyuan Li Jian Hao Risk factors for cardio-cerebrovascular events among patients undergoing continuous ambulatory peritoneal dialysis and their association with serum magnesium Renal Failure Chronic kidney disease (CKD) continuous ambulatory peritoneal dialysis (CAPD) magnesium cardiovascular and cerebrovascular diseases (CVDs) |
| title | Risk factors for cardio-cerebrovascular events among patients undergoing continuous ambulatory peritoneal dialysis and their association with serum magnesium |
| title_full | Risk factors for cardio-cerebrovascular events among patients undergoing continuous ambulatory peritoneal dialysis and their association with serum magnesium |
| title_fullStr | Risk factors for cardio-cerebrovascular events among patients undergoing continuous ambulatory peritoneal dialysis and their association with serum magnesium |
| title_full_unstemmed | Risk factors for cardio-cerebrovascular events among patients undergoing continuous ambulatory peritoneal dialysis and their association with serum magnesium |
| title_short | Risk factors for cardio-cerebrovascular events among patients undergoing continuous ambulatory peritoneal dialysis and their association with serum magnesium |
| title_sort | risk factors for cardio cerebrovascular events among patients undergoing continuous ambulatory peritoneal dialysis and their association with serum magnesium |
| topic | Chronic kidney disease (CKD) continuous ambulatory peritoneal dialysis (CAPD) magnesium cardiovascular and cerebrovascular diseases (CVDs) |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2355354 |
| work_keys_str_mv | AT pengleili riskfactorsforcardiocerebrovasculareventsamongpatientsundergoingcontinuousambulatoryperitonealdialysisandtheirassociationwithserummagnesium AT tieganglv riskfactorsforcardiocerebrovasculareventsamongpatientsundergoingcontinuousambulatoryperitonealdialysisandtheirassociationwithserummagnesium AT lipingxu riskfactorsforcardiocerebrovasculareventsamongpatientsundergoingcontinuousambulatoryperitonealdialysisandtheirassociationwithserummagnesium AT wenluyu riskfactorsforcardiocerebrovasculareventsamongpatientsundergoingcontinuousambulatoryperitonealdialysisandtheirassociationwithserummagnesium AT yuanyuanlu riskfactorsforcardiocerebrovasculareventsamongpatientsundergoingcontinuousambulatoryperitonealdialysisandtheirassociationwithserummagnesium AT yuanyuanli riskfactorsforcardiocerebrovasculareventsamongpatientsundergoingcontinuousambulatoryperitonealdialysisandtheirassociationwithserummagnesium AT jianhao riskfactorsforcardiocerebrovasculareventsamongpatientsundergoingcontinuousambulatoryperitonealdialysisandtheirassociationwithserummagnesium |