On the Evaluation of the Hyperthermic Efficiency of Magnetic Scaffolds
<italic>Goal:</italic> Deep-seated tumors (DST) can be treated using thermoseeds exposed to a radiofrequency magnetic field for performing local interstitial hyperthermia treatment (HT). Several research efforts were oriented to the manufacturing of novel biocompatible magnetic nanostruc...
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IEEE
2024-01-01
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| Series: | IEEE Open Journal of Engineering in Medicine and Biology |
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| Online Access: | https://ieeexplore.ieee.org/document/10216329/ |
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| author | Matteo B. Lodi Antonios Makridis Konstantina Kazeli Theodoros Samaras Makis Angelakeris Giuseppe Mazzarella Alessandro Fanti |
| author_facet | Matteo B. Lodi Antonios Makridis Konstantina Kazeli Theodoros Samaras Makis Angelakeris Giuseppe Mazzarella Alessandro Fanti |
| author_sort | Matteo B. Lodi |
| collection | DOAJ |
| description | <italic>Goal:</italic> Deep-seated tumors (DST) can be treated using thermoseeds exposed to a radiofrequency magnetic field for performing local interstitial hyperthermia treatment (HT). Several research efforts were oriented to the manufacturing of novel biocompatible magnetic nanostructured thermo-seeds, called magnetic scaffolds (MagS). Several iron-doped bioceramics or magnetic polymers in various formulations are available. However, the crucial evaluation of their heating potential has been carried out with significantly different, lab specific, variable experimental conditions and protocols often ignoring the several error sources and inaccuracies estimation. <italic>Methods:</italic> This work comments and provides a perspective analysis of an experimental protocol for the estimation methodology of the specific absorption rate (SAR) of MagS for DST HT. Numerical multiphysics simultions have been performed to outline the theoretical framework. After the in silico analysis, an experimental case is considered and tested. <italic>Results:</italic> From the simulations, we found that large overestimation in the SAR values can be found, due to the axial misplacement in the radiofrequency coil, while the radial misplacement has a lower impact on the estimated SAR value. <italic>Conclusions:</italic> The averaging of multiple temperature records is needed to reliably and effectively estimate the SAR of MagS for DST HT. |
| format | Article |
| id | doaj-art-f6841f7b26764e68a34ade685641c83c |
| institution | Kabale University |
| issn | 2644-1276 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Open Journal of Engineering in Medicine and Biology |
| spelling | doaj-art-f6841f7b26764e68a34ade685641c83c2025-01-30T00:03:39ZengIEEEIEEE Open Journal of Engineering in Medicine and Biology2644-12762024-01-015889810.1109/OJEMB.2023.330481210216329On the Evaluation of the Hyperthermic Efficiency of Magnetic ScaffoldsMatteo B. Lodi0https://orcid.org/0000-0002-8314-1575Antonios Makridis1https://orcid.org/0000-0002-7609-1362Konstantina Kazeli2https://orcid.org/0000-0002-7426-3706Theodoros Samaras3https://orcid.org/0000-0003-0170-4520Makis Angelakeris4https://orcid.org/0000-0001-9109-0221Giuseppe Mazzarella5https://orcid.org/0000-0002-1429-9600Alessandro Fanti6https://orcid.org/0000-0001-6218-881XDepartment of Electrical and Electronic Engineering, University of Cagliari, Cagliari, ItalyNanostructure Characterization: Technology and Applications, CIRI-AUTH, Thessaloniki, GreeceNanostructure Characterization: Technology and Applications, CIRI-AUTH, Thessaloniki, GreeceNanostructure Characterization: Technology and Applications, CIRI-AUTH, Thessaloniki, GreeceNanostructure Characterization: Technology and Applications, CIRI-AUTH, Thessaloniki, GreeceDepartment of Electrical and Electronic Engineering, University of Cagliari, Cagliari, ItalyDepartment of Electrical and Electronic Engineering, University of Cagliari, Cagliari, Italy<italic>Goal:</italic> Deep-seated tumors (DST) can be treated using thermoseeds exposed to a radiofrequency magnetic field for performing local interstitial hyperthermia treatment (HT). Several research efforts were oriented to the manufacturing of novel biocompatible magnetic nanostructured thermo-seeds, called magnetic scaffolds (MagS). Several iron-doped bioceramics or magnetic polymers in various formulations are available. However, the crucial evaluation of their heating potential has been carried out with significantly different, lab specific, variable experimental conditions and protocols often ignoring the several error sources and inaccuracies estimation. <italic>Methods:</italic> This work comments and provides a perspective analysis of an experimental protocol for the estimation methodology of the specific absorption rate (SAR) of MagS for DST HT. Numerical multiphysics simultions have been performed to outline the theoretical framework. After the in silico analysis, an experimental case is considered and tested. <italic>Results:</italic> From the simulations, we found that large overestimation in the SAR values can be found, due to the axial misplacement in the radiofrequency coil, while the radial misplacement has a lower impact on the estimated SAR value. <italic>Conclusions:</italic> The averaging of multiple temperature records is needed to reliably and effectively estimate the SAR of MagS for DST HT.https://ieeexplore.ieee.org/document/10216329/Heating evaluation protocolhyperthermiamagnetic biomaterialsspecific absorption rate |
| spellingShingle | Matteo B. Lodi Antonios Makridis Konstantina Kazeli Theodoros Samaras Makis Angelakeris Giuseppe Mazzarella Alessandro Fanti On the Evaluation of the Hyperthermic Efficiency of Magnetic Scaffolds IEEE Open Journal of Engineering in Medicine and Biology Heating evaluation protocol hyperthermia magnetic biomaterials specific absorption rate |
| title | On the Evaluation of the Hyperthermic Efficiency of Magnetic Scaffolds |
| title_full | On the Evaluation of the Hyperthermic Efficiency of Magnetic Scaffolds |
| title_fullStr | On the Evaluation of the Hyperthermic Efficiency of Magnetic Scaffolds |
| title_full_unstemmed | On the Evaluation of the Hyperthermic Efficiency of Magnetic Scaffolds |
| title_short | On the Evaluation of the Hyperthermic Efficiency of Magnetic Scaffolds |
| title_sort | on the evaluation of the hyperthermic efficiency of magnetic scaffolds |
| topic | Heating evaluation protocol hyperthermia magnetic biomaterials specific absorption rate |
| url | https://ieeexplore.ieee.org/document/10216329/ |
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