PROTAC-based therapeutics for targeting HPV oncoproteins in head and neck cancers
The increasing incidence of Human Papillomavirus (HPV)-related head and neck cancers, particularly oropharyngeal squamous cell carcinomas, highlights the need for advanced therapeutic options beyond the traditional modalities of surgery, radiation, and chemotherapy, which often lead to significant m...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-12-01
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| Series: | Nano TransMed |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2790676025000020 |
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| author | Nobendu Mukerjee Dattatreya Mukherjee |
| author_facet | Nobendu Mukerjee Dattatreya Mukherjee |
| author_sort | Nobendu Mukerjee |
| collection | DOAJ |
| description | The increasing incidence of Human Papillomavirus (HPV)-related head and neck cancers, particularly oropharyngeal squamous cell carcinomas, highlights the need for advanced therapeutic options beyond the traditional modalities of surgery, radiation, and chemotherapy, which often lead to significant morbidity and lack specificity in targeting the molecular pathogenesis of the disease. Proteolysis Targeting Chimeras (PROTACs) present a novel therapeutic strategy, leveraging the ubiquitin-proteasome system to specifically degrade the oncogenic HPV proteins E6 and E7. This targeted approach not only potentially reduces the side effects associated with conventional treatments but also directly interrupts the cancer-promoting activities of these proteins, offering a promising avenue for more effective and less invasive treatment of HPV-associated malignancies. |
| format | Article |
| id | doaj-art-f67c438ec68e41a6bc3d78681c52140f |
| institution | Kabale University |
| issn | 2790-6760 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Nano TransMed |
| spelling | doaj-art-f67c438ec68e41a6bc3d78681c52140f2025-02-05T04:32:54ZengKeAi Communications Co., Ltd.Nano TransMed2790-67602025-12-014100071PROTAC-based therapeutics for targeting HPV oncoproteins in head and neck cancersNobendu Mukerjee0Dattatreya Mukherjee1Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, India; Corresponding authors.Department of Medicine, Raiganj Government Medical College and Hospital, West Bengal, India; Corresponding authors.The increasing incidence of Human Papillomavirus (HPV)-related head and neck cancers, particularly oropharyngeal squamous cell carcinomas, highlights the need for advanced therapeutic options beyond the traditional modalities of surgery, radiation, and chemotherapy, which often lead to significant morbidity and lack specificity in targeting the molecular pathogenesis of the disease. Proteolysis Targeting Chimeras (PROTACs) present a novel therapeutic strategy, leveraging the ubiquitin-proteasome system to specifically degrade the oncogenic HPV proteins E6 and E7. This targeted approach not only potentially reduces the side effects associated with conventional treatments but also directly interrupts the cancer-promoting activities of these proteins, offering a promising avenue for more effective and less invasive treatment of HPV-associated malignancies.http://www.sciencedirect.com/science/article/pii/S2790676025000020PROTACsHead and Neck CancerHPVTargeted destruction |
| spellingShingle | Nobendu Mukerjee Dattatreya Mukherjee PROTAC-based therapeutics for targeting HPV oncoproteins in head and neck cancers Nano TransMed PROTACs Head and Neck Cancer HPV Targeted destruction |
| title | PROTAC-based therapeutics for targeting HPV oncoproteins in head and neck cancers |
| title_full | PROTAC-based therapeutics for targeting HPV oncoproteins in head and neck cancers |
| title_fullStr | PROTAC-based therapeutics for targeting HPV oncoproteins in head and neck cancers |
| title_full_unstemmed | PROTAC-based therapeutics for targeting HPV oncoproteins in head and neck cancers |
| title_short | PROTAC-based therapeutics for targeting HPV oncoproteins in head and neck cancers |
| title_sort | protac based therapeutics for targeting hpv oncoproteins in head and neck cancers |
| topic | PROTACs Head and Neck Cancer HPV Targeted destruction |
| url | http://www.sciencedirect.com/science/article/pii/S2790676025000020 |
| work_keys_str_mv | AT nobendumukerjee protacbasedtherapeuticsfortargetinghpvoncoproteinsinheadandneckcancers AT dattatreyamukherjee protacbasedtherapeuticsfortargetinghpvoncoproteinsinheadandneckcancers |