Development of a prognostic model based on four genes related to exhausted CD8+ T cell in triple-negative breast cancer patients: a comprehensive analysis integrating scRNA-seq and bulk RNA-seq

Development of a prognostic model based on four genes related to exhausted CD8+ T cell in triple-negative breast cancer patients: a comprehensive analysis integrating scRNA-seq and bulk RNA-seq

Abstract Low immune infiltration is closely associated with poor clinical results and an unfavorable response to therapy in triple-negative breast cancer (TNBC). T-cell exhaustion (TEX) is a significant risk factor for tumor immunosuppression and invasion. Although improving TEX and enhancing effect...

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Bibliographic Details
Main Authors: Yulin Shi, Yang Yu, Jiahan Zhao, Linan Huang, Qingyang Wang, Qi Sun, Lijuan Liu, Changgang Sun
Format: Article
Language:English
Published: Springer 2025-02-01
Series:Discover Oncology
Subjects:
Exhausted CD8+ T cell
Triple-negative breast cancer
Single-cell RNA sequencing
Cellular communication
Tumor immune microenvironment
Online Access:https://doi.org/10.1007/s12672-025-01812-z
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