Hepcidin: A Critical Regulator of Iron Metabolism during Hypoxia
Iron status affects cognitive and physical performance in humans. Recent evidence indicates that iron balance is a tightly regulated process affected by a series of factors other than diet, to include hypoxia. Hypoxia has profound effects on iron absorption and results in increased iron acquisition...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2011/510304 |
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| _version_ | 1832565414286065664 |
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| author | Korry J. Hintze James P. McClung |
| author_facet | Korry J. Hintze James P. McClung |
| author_sort | Korry J. Hintze |
| collection | DOAJ |
| description | Iron status affects cognitive and physical performance in humans. Recent evidence indicates that iron balance is a tightly regulated process affected by a series of factors other than diet, to include hypoxia. Hypoxia has profound effects on iron absorption and results in increased iron acquisition and erythropoiesis when humans move from sea level to altitude. The effects of hypoxia on iron balance have been attributed to hepcidin, a central regulator of iron homeostasis. This paper will focus on the molecular mechanisms by which hypoxia affects hepcidin expression, to include a review of the hypoxia inducible factor (HIF)/hypoxia response element (HRE) system, as well as recent evidence indicating that localized adipose hypoxia due to obesity may affect hepcidin signaling and organismal iron metabolism. |
| format | Article |
| id | doaj-art-f675f2d605f04f848b85973c9d62fbfe |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-f675f2d605f04f848b85973c9d62fbfe2025-02-03T01:07:59ZengWileyAdvances in Hematology1687-91041687-91122011-01-01201110.1155/2011/510304510304Hepcidin: A Critical Regulator of Iron Metabolism during HypoxiaKorry J. Hintze0James P. McClung1Department of Nutrition, Dietetics & Food Sciences, Utah State University, Logan, UT 84322, USAMilitary Nutrition Division, US Army Research Institute of Environmental Medicine (USARIEM), Natick, MA 01760, USAIron status affects cognitive and physical performance in humans. Recent evidence indicates that iron balance is a tightly regulated process affected by a series of factors other than diet, to include hypoxia. Hypoxia has profound effects on iron absorption and results in increased iron acquisition and erythropoiesis when humans move from sea level to altitude. The effects of hypoxia on iron balance have been attributed to hepcidin, a central regulator of iron homeostasis. This paper will focus on the molecular mechanisms by which hypoxia affects hepcidin expression, to include a review of the hypoxia inducible factor (HIF)/hypoxia response element (HRE) system, as well as recent evidence indicating that localized adipose hypoxia due to obesity may affect hepcidin signaling and organismal iron metabolism.http://dx.doi.org/10.1155/2011/510304 |
| spellingShingle | Korry J. Hintze James P. McClung Hepcidin: A Critical Regulator of Iron Metabolism during Hypoxia Advances in Hematology |
| title | Hepcidin: A Critical Regulator of Iron Metabolism during Hypoxia |
| title_full | Hepcidin: A Critical Regulator of Iron Metabolism during Hypoxia |
| title_fullStr | Hepcidin: A Critical Regulator of Iron Metabolism during Hypoxia |
| title_full_unstemmed | Hepcidin: A Critical Regulator of Iron Metabolism during Hypoxia |
| title_short | Hepcidin: A Critical Regulator of Iron Metabolism during Hypoxia |
| title_sort | hepcidin a critical regulator of iron metabolism during hypoxia |
| url | http://dx.doi.org/10.1155/2011/510304 |
| work_keys_str_mv | AT korryjhintze hepcidinacriticalregulatorofironmetabolismduringhypoxia AT jamespmcclung hepcidinacriticalregulatorofironmetabolismduringhypoxia |