Faecalibacterium longum alleviates high-fat diet-induced obesity and protects the intestinal epithelial barrier in mice
Numerous studies have indicated that depletion of Faecalibacterium is related to obesity. Here we show that Faecalibacterium longum CM04–06 out of 29 strains of the Faecalibacterium genus annotated in CGR2 exhibited the strongest inverse correlation with body mass index (BMI) in a cohort of 1120 han...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-02-01
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| Series: | Gut Microbes Reports |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/29933935.2025.2459599 |
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| author | Haoyu Wang Shengnan Yu Kunyi Zhao Tongyuan Hu Zhinan Wu Hewei Liang Xiaoqian Lin Luwen Cui Jingtong Yao Xiaomin Liu Xin Tong Ningning He Liang Xiao Karsten Kristiansen Shangyong Li Yuanqiang Zou |
| author_facet | Haoyu Wang Shengnan Yu Kunyi Zhao Tongyuan Hu Zhinan Wu Hewei Liang Xiaoqian Lin Luwen Cui Jingtong Yao Xiaomin Liu Xin Tong Ningning He Liang Xiao Karsten Kristiansen Shangyong Li Yuanqiang Zou |
| author_sort | Haoyu Wang |
| collection | DOAJ |
| description | Numerous studies have indicated that depletion of Faecalibacterium is related to obesity. Here we show that Faecalibacterium longum CM04–06 out of 29 strains of the Faecalibacterium genus annotated in CGR2 exhibited the strongest inverse correlation with body mass index (BMI) in a cohort of 1120 han Chinese individuals. Administration of F. longum CM04–06 to mice prevented high-fat diet (HFD)-induced obesity, improved glucose tolerance, reduced adipose tissues mass, and liver steatosis. Supplementation with F. longum CM04–06 reduced the level of pro-inflammatory cytokines in liver, colon, and circulation. F. longum CM04–06 protected the intestinal epithelial barrier increasing the expression of tight junction proteins. Metagenomic sequencing indicated that F. longum supplementation did not change the overall composition of the gut microbiota in mice, but selectively increased the relative abundance of Staphylococcus xylosus and Staphylococcus nepalensis. In conclusion, our results point to a potential therapeutic potential of F. longum CM04–06. |
| format | Article |
| id | doaj-art-f668d9fee0b44d22ad6d41e0a70bbb74 |
| institution | Kabale University |
| issn | 2993-3935 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes Reports |
| spelling | doaj-art-f668d9fee0b44d22ad6d41e0a70bbb742025-01-31T13:49:48ZengTaylor & Francis GroupGut Microbes Reports2993-39352025-02-0111310.1080/29933935.2025.2459599Faecalibacterium longum alleviates high-fat diet-induced obesity and protects the intestinal epithelial barrier in miceHaoyu Wang0Shengnan Yu1Kunyi Zhao2Tongyuan Hu3Zhinan Wu4Hewei Liang5Xiaoqian Lin6Luwen Cui7Jingtong Yao8Xiaomin Liu9Xin Tong10Ningning He11Liang Xiao12Karsten Kristiansen13Shangyong Li14Yuanqiang Zou15BGI Research, Shenzhen, ChinaSchool of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao, ChinaBGI Research, Shenzhen, ChinaBGI Research, Shenzhen, ChinaBGI Research, Shenzhen, ChinaBGI Research, Shenzhen, ChinaSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou, ChinaSchool of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao, ChinaSchool of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao, ChinaBGI Research, Shenzhen, ChinaBGI Research, Shenzhen, ChinaSchool of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao, ChinaBGI Research, Shenzhen, ChinaBGI Research, Shenzhen, ChinaSchool of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao, ChinaBGI Research, Shenzhen, ChinaNumerous studies have indicated that depletion of Faecalibacterium is related to obesity. Here we show that Faecalibacterium longum CM04–06 out of 29 strains of the Faecalibacterium genus annotated in CGR2 exhibited the strongest inverse correlation with body mass index (BMI) in a cohort of 1120 han Chinese individuals. Administration of F. longum CM04–06 to mice prevented high-fat diet (HFD)-induced obesity, improved glucose tolerance, reduced adipose tissues mass, and liver steatosis. Supplementation with F. longum CM04–06 reduced the level of pro-inflammatory cytokines in liver, colon, and circulation. F. longum CM04–06 protected the intestinal epithelial barrier increasing the expression of tight junction proteins. Metagenomic sequencing indicated that F. longum supplementation did not change the overall composition of the gut microbiota in mice, but selectively increased the relative abundance of Staphylococcus xylosus and Staphylococcus nepalensis. In conclusion, our results point to a potential therapeutic potential of F. longum CM04–06.https://www.tandfonline.com/doi/10.1080/29933935.2025.2459599Faecalibacteriumgut microbiotametabolic diseasemetagenomic sequencingcohort study |
| spellingShingle | Haoyu Wang Shengnan Yu Kunyi Zhao Tongyuan Hu Zhinan Wu Hewei Liang Xiaoqian Lin Luwen Cui Jingtong Yao Xiaomin Liu Xin Tong Ningning He Liang Xiao Karsten Kristiansen Shangyong Li Yuanqiang Zou Faecalibacterium longum alleviates high-fat diet-induced obesity and protects the intestinal epithelial barrier in mice Gut Microbes Reports Faecalibacterium gut microbiota metabolic disease metagenomic sequencing cohort study |
| title | Faecalibacterium longum alleviates high-fat diet-induced obesity and protects the intestinal epithelial barrier in mice |
| title_full | Faecalibacterium longum alleviates high-fat diet-induced obesity and protects the intestinal epithelial barrier in mice |
| title_fullStr | Faecalibacterium longum alleviates high-fat diet-induced obesity and protects the intestinal epithelial barrier in mice |
| title_full_unstemmed | Faecalibacterium longum alleviates high-fat diet-induced obesity and protects the intestinal epithelial barrier in mice |
| title_short | Faecalibacterium longum alleviates high-fat diet-induced obesity and protects the intestinal epithelial barrier in mice |
| title_sort | faecalibacterium longum alleviates high fat diet induced obesity and protects the intestinal epithelial barrier in mice |
| topic | Faecalibacterium gut microbiota metabolic disease metagenomic sequencing cohort study |
| url | https://www.tandfonline.com/doi/10.1080/29933935.2025.2459599 |
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