Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer

Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer

Abstract Proteasome is an essential organelle responsible for maintaining cellular protein homeostasis, but its relationship with DNA methylation remains unknown. In this study, we assessed DNA methylation of colorectal cancer (CRC) cells following treatment with proteasome inhibitors, and investiga...

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Main Authors: Wenwen Zhou, Yuling Sheng, Dingxue Hu, Yunyun An, Mengqi Yang, Wanqiu Wang, Shiva Basnet, Jingyu Yan, Shuxia Zhang, Qi Liu, Yunze Li, Yi Tan, Jing Gao, Kun Sun, Changzheng Du
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Proteasome
DNA methyltransferase
Colorectal cancer
Online Access:https://doi.org/10.1038/s41598-025-92390-1
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https://doi.org/10.1038/s41598-025-92390-1

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