The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat: Is There a Link?
Oxidative stress is regarded as a pathogenic factor in hyperthyroidism. Our purpose was to determine the relationship between the oxidative stress and the inflammatory cytokines and to investigate how melatonin affects oxidative damage and cytokine response in thyrotoxic rats. Twenty-one rats were d...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2009/391682 |
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| author | Balahan Makay Ozer Makay Cigdem Yenisey Gokhan Icoz Gokhan Ozgen Erbil Unsal Mahir Akyildiz Enis Yetkin |
| author_facet | Balahan Makay Ozer Makay Cigdem Yenisey Gokhan Icoz Gokhan Ozgen Erbil Unsal Mahir Akyildiz Enis Yetkin |
| author_sort | Balahan Makay |
| collection | DOAJ |
| description | Oxidative stress is regarded as a pathogenic factor in hyperthyroidism. Our purpose was to determine the relationship between the oxidative stress and the inflammatory cytokines and to investigate how melatonin affects oxidative damage and cytokine response in thyrotoxic rats. Twenty-one rats were divided into three groups. Group A served as negative controls. Group B had untreated thyrotoxicosis, and Group C received melatonin. Serum malondialdehyde (MDA), glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx), and nitric oxide derivates (NO•x), and plasma IL-6, IL-10, and TNF-alpha were measured. MDA, GSH, NO•x, IL-10, and TNF-alpha levels increased after L-thyroxine induction. An inhibition of triiodothyronine and thyroxine was detected, as a result of melatonin administration. MDA, GSH, and NO•x levels were also affected by melatonin. Lowest TNF-alpha levels were observed in Group C. This study demonstrates that oxidative stress is related to cytokine response in the thyrotoxic rat. Melatonin treatment suppresses the hyperthyroidism-induced oxidative damage as well as TNF-alpha response. |
| format | Article |
| id | doaj-art-f654e8dd1395409aaf061e92bc4f98ba |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-f654e8dd1395409aaf061e92bc4f98ba2025-02-03T06:14:05ZengWileyMediators of Inflammation0962-93511466-18612009-01-01200910.1155/2009/391682391682The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat: Is There a Link?Balahan Makay0Ozer Makay1Cigdem Yenisey2Gokhan Icoz3Gokhan Ozgen4Erbil Unsal5Mahir Akyildiz6Enis Yetkin7Division of Pediatric Rheumatology and Immunology, Department of Pediatrics, School of Medicine, Dokuz Eylul University, 35340 Inciralti, Izmir, TurkeyDepartment of General Surgery, School of Medicine, Ege University, 35100 Izmir, TurkeyDepartment of Biochemistry, School of Medicine, Adnan Menderes University, 09890 Aydin, TurkeyDepartment of General Surgery, School of Medicine, Ege University, 35100 Izmir, TurkeyDivision of Endocrinology, Department of Internal Medicine, School of Medicine, Ege University, 35100 Izmir, TurkeyDivision of Pediatric Rheumatology and Immunology, Department of Pediatrics, School of Medicine, Dokuz Eylul University, 35340 Inciralti, Izmir, TurkeyDepartment of General Surgery, School of Medicine, Ege University, 35100 Izmir, TurkeyDepartment of General Surgery, School of Medicine, Ege University, 35100 Izmir, TurkeyOxidative stress is regarded as a pathogenic factor in hyperthyroidism. Our purpose was to determine the relationship between the oxidative stress and the inflammatory cytokines and to investigate how melatonin affects oxidative damage and cytokine response in thyrotoxic rats. Twenty-one rats were divided into three groups. Group A served as negative controls. Group B had untreated thyrotoxicosis, and Group C received melatonin. Serum malondialdehyde (MDA), glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx), and nitric oxide derivates (NO•x), and plasma IL-6, IL-10, and TNF-alpha were measured. MDA, GSH, NO•x, IL-10, and TNF-alpha levels increased after L-thyroxine induction. An inhibition of triiodothyronine and thyroxine was detected, as a result of melatonin administration. MDA, GSH, and NO•x levels were also affected by melatonin. Lowest TNF-alpha levels were observed in Group C. This study demonstrates that oxidative stress is related to cytokine response in the thyrotoxic rat. Melatonin treatment suppresses the hyperthyroidism-induced oxidative damage as well as TNF-alpha response.http://dx.doi.org/10.1155/2009/391682 |
| spellingShingle | Balahan Makay Ozer Makay Cigdem Yenisey Gokhan Icoz Gokhan Ozgen Erbil Unsal Mahir Akyildiz Enis Yetkin The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat: Is There a Link? Mediators of Inflammation |
| title | The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat: Is There a Link? |
| title_full | The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat: Is There a Link? |
| title_fullStr | The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat: Is There a Link? |
| title_full_unstemmed | The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat: Is There a Link? |
| title_short | The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat: Is There a Link? |
| title_sort | interaction of oxidative stress response with cytokines in the thyrotoxic rat is there a link |
| url | http://dx.doi.org/10.1155/2009/391682 |
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