MGAT1-Guided complex N-Glycans on CD73 regulate immune evasion in triple-negative breast cancer

MGAT1-Guided complex N-Glycans on CD73 regulate immune evasion in triple-negative breast cancer

Abstract Despite the widespread application of immunotherapy, treating immune-cold tumors remains a significant challenge in cancer therapy. Using multiomic spatial analyses and experimental validation, we identify MGAT1, a glycosyltransferase, as a pivotal factor governing tumor immune response. Ov...

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Main Authors: Junlong Jack Chi, Ping Xie, Mary Hongying Cheng, Yueming Zhu, Xin Cui, Joshua Watson, Lidan Zeng, Amad Uddin, Hoang Nguyen, Lei Li, Kelley Moremen, April Reedy, Megan Wyatt, Adam Marcus, Mingji Dai, Chrystal M. Paulos, Massimo Cristofanilli, William J. Gradishar, Shaying Zhao, Kevin Kalinsky, Mine-Chie Hung, Ivet Bahar, Bin Zhang, Yong Wan
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58524-9
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