Microenvironment Influences on Human Umbilical Cord Mesenchymal Stem Cell-Based Bone Regeneration

Microenvironment Influences on Human Umbilical Cord Mesenchymal Stem Cell-Based Bone Regeneration

The microenvironment, or niche, regulates stem cell fate and improves differentiation efficiency. Human umbilical cord mesenchymal stem cells (hUC-MSCs) are ideal cell source for bone tissue engineering. However, the role of the microenvironments in hUC-MSC-based bone regeneration is not yet fully u...

Full description

Saved in:

Bibliographic Details
Main Authors:	Lingling E, Rongjian Lu, Jianwei Sun, Hongbo Li, Wen Xu, Helin Xing, Xing Wang, Tao Cheng, Shuo Zhang, Xiaocao Ma, Rong Zhang, Hongchen Liu
Format:	Article
Language:	English
Published:	Wiley 2021-01-01
Series:	Stem Cells International
Online Access:	http://dx.doi.org/10.1155/2021/4465022
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Umbilical cord mesenchymal stem cells improve bone regeneration in diabetes mellitus animal model with apical periodontitis
by: Eric Priyo Prasetyo, et al.
Published: (2025-01-01)

Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications
by: E. Russo, et al.
Published: (2022-01-01)

Research Progress on Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis
by: GONG Jin, et al.
Published: (2025-01-01)

Bone Microenvironment, Stem Cells, and Bone Tissue Regeneration
by: ZuFu Lu, et al.
Published: (2017-01-01)

Bone Defect Repair Using a Bone Substitute Supported by Mesenchymal Stem Cells Derived from the Umbilical Cord
by: Michal Kosinski, et al.
Published: (2020-01-01)

Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy
by: Irina Arutyunyan, et al.
Published: (2016-01-01)

Umbilical Cord Mesenchymal Stem Cells Ameliorate Inflammation-Related Tumorigenesis via Modulating Macrophages
by: Yanxia Fu, et al.
Published: (2022-01-01)

The Effect of Exosomes Derived from Human Umbilical Cord Mesenchymal Stromal/Stem Cells on the Regeneration of Human Pulpectomized Tooth: A Case Report
by: Nazanin Jafari, et al.
Published: (2025-01-01)

Semaphorin3B Promotes Proliferation and Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in a High-Glucose Microenvironment
by: Quan Xing, et al.
Published: (2021-01-01)

Restoration of a Critical Mandibular Bone Defect Using Human Alveolar Bone-Derived Stem Cells and Porous Nano-HA/Collagen/PLA Scaffold
by: Xing Wang, et al.
Published: (2016-01-01)

Therapeutic potential and mechanisms of umbilical cord mesenchymal stem cells differentiating into tendon cells and promotion of rotator cuff tendon-bone healing
by: Youliang Shen, et al.
Published: (2025-01-01)

Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy
by: Liming Wang, et al.
Published: (2016-01-01)

Current Status of Canine Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Veterinary Medicine
by: Tania Sultana, et al.
Published: (2018-01-01)

Resveratrol Induces Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Neuron-Like Cells
by: Li Guo, et al.
Published: (2017-01-01)

Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells at Various Passages on Acute Liver Failure in Rats
by: Yongting Zhang, et al.
Published: (2018-01-01)

Activated Human Umbilical Cord Blood Platelet-Rich Plasma Enhances the Beneficial Effects of Human Umbilical Cord Mesenchymal Stem Cells in Chemotherapy-Induced POF Rats
by: Jiawei Wang, et al.
Published: (2021-01-01)

Umbilical Cord-Derived Mesenchymal Stem Cells Relieve Hindlimb Ischemia through Enhancing Angiogenesis in Tree Shrews
by: Cunping Yin, et al.
Published: (2016-01-01)

Long-term hypoxic atmosphere enhances the stemness, immunoregulatory functions, and therapeutic application of human umbilical cord mesenchymal stem cells
by: Qi-Ming Huang, et al.
Published: (2024-12-01)

Comparison of Immunological Characteristics of Mesenchymal Stem Cells from the Periodontal Ligament, Umbilical Cord, and Adipose Tissue
by: Jin-Hee Kim, et al.
Published: (2018-01-01)

PLL-g-HPA Hydrogel Loaded Human Umbilical Cord Mesenchymal Stem Cells Promote Burn Wound Healing in Rat Model by Regulating Inflammation Response
by: Tian L, et al.
Published: (2025-01-01)

Mesenchymal Stem Cells as a Potent Cell Source for Bone Regeneration
by: Elham Zomorodian, et al.
Published: (2012-01-01)

Efficacy of human umbilical cord mesenchymal stem cell in the treatment of neuromyelitis optica spectrum disorders: an animal study
by: Chunran Xue, et al.
Published: (2025-02-01)

Therapeutic Potential of HGF-Expressing Human Umbilical Cord Mesenchymal Stem Cells in Mice with Acute Liver Failure
by: Yunxia Tang, et al.
Published: (2016-01-01)

Cryopreserved Umbilical Cord Mesenchymal Stem Cells Show Comparable Effects to Un-Cryopreserved Cells in Treating Osteoarthritis
by: Bo Yan, et al.
Published: (2025-01-01)

Human Umbilical Cord Mesenchymal Stem Cells Encapsulated with Pluronic F-127 Enhance the Regeneration and Angiogenesis of Thin Endometrium in Rat via Local IL-1β Stimulation
by: Shuling Zhou, et al.
Published: (2022-01-01)

Integration of Umbilical Cord Mesenchymal Stem Cell Application in Hydroxyapatite-Based Scaffolds in the Treatment of Vertebral Bone Defect due to Spondylitis Tuberculosis: A Translational Study
by: Ahmad Jabir Rahyussalim, et al.
Published: (2021-01-01)

Comparative Analysis of Human Mesenchymal Stem Cells from Umbilical Cord, Dental Pulp, and Menstrual Blood as Sources for Cell Therapy
by: Huaijuan Ren, et al.
Published: (2016-01-01)

An Overview of Long Noncoding RNAs Involved in Bone Regeneration from Mesenchymal Stem Cells
by: Shuping Peng, et al.
Published: (2018-01-01)

Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria
by: Jinyun Chen, et al.
Published: (2016-01-01)

Umbilical Cord Mesenchymal Stem Cells Overexpressing Heme Oxygenase-1 Promotes Symptoms Recovery in Cystitis Rats by Alleviating Neuroinflammation
by: Qiongqiong Gao, et al.
Published: (2023-01-01)

Genetic Comparison of Stemness of Human Umbilical Cord and Dental Pulp
by: Chung-Min Kang, et al.
Published: (2016-01-01)

Callus Formation in Fractured Femur of Rats Treated with Injection of Human Umbilical Cord Mesenchymal Stem Cell-Conditioned Medium
by: Marla Anggita, et al.
Published: (2021-01-01)

Human umbilical cord derived-mesenchymal stem cells alleviate lipid metabolism disturbances of hepatocytes via mitochondrial transport
by: Jing Xue, et al.
Published: (2025-01-01)

What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?
by: R. N. Bárcia, et al.
Published: (2015-01-01)

Semaphorin 3A Shifts Adipose Mesenchymal Stem Cells towards Osteogenic Phenotype and Promotes Bone Regeneration In Vivo
by: Xiangwei Liu, et al.
Published: (2016-01-01)

Urothelial Differentiation of Human Umbilical Cord-Derived Mesenchymal Stromal Cells In Vitro
by: Shuai Wu, et al.
Published: (2013-01-01)

A Small-Sized Population of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Shows High Stemness Properties and Therapeutic Benefit
by: Miyeon Kim, et al.
Published: (2020-01-01)

Tumor Necrosis Factor Receptor 1 Is Required for Human Umbilical Cord–Derived Mesenchymal Stem Cell–Mediated Rheumatoid Arthritis Therapy
by: Guangyang Liu, et al.
Published: (2025-01-01)

The Combined Use of Platelet-Rich Plasma Clot Releasate and Allogeneic Human Umbilical Cord Mesenchymal Stem Cells Rescue Glucocorticoid-Induced Osteonecrosis of the Femoral Head
by: Yanxue Wang, et al.
Published: (2022-01-01)

The Crosstalk between Mesenchymal Stem Cells and Macrophages in Bone Regeneration: A Systematic Review
by: Rita Lih-Ying Shin, et al.
Published: (2021-01-01)