Low-level auricular vagus nerve stimulation lowers blood pressure and heart rate in paroxysmal atrial fibrillation patients: a self-controlled study
ObjectiveTo investigate the effects of low-level auricular vagus nerve stimulation (LL-aVNS) on blood pressure and heart rate in patients with paroxysmal atrial fibrillation.MethodsA total of 22 patients with paroxysmal atrial fibrillation diagnosed in Fuzhou First General Hospital Affiliated with F...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2025.1525027/full |
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| author | Yu Jiang Yu Jiang Di Su Jingwen Xiao Jingwen Xiao Wenbo Cheng Yuemei Hou Yan Zhang Yan Zhang |
| author_facet | Yu Jiang Yu Jiang Di Su Jingwen Xiao Jingwen Xiao Wenbo Cheng Yuemei Hou Yan Zhang Yan Zhang |
| author_sort | Yu Jiang |
| collection | DOAJ |
| description | ObjectiveTo investigate the effects of low-level auricular vagus nerve stimulation (LL-aVNS) on blood pressure and heart rate in patients with paroxysmal atrial fibrillation.MethodsA total of 22 patients with paroxysmal atrial fibrillation diagnosed in Fuzhou First General Hospital Affiliated with Fujian Medical University from September 2021 to December 2022 were selected and given LL-aVNS treatment based on the original unchanged drug treatment for 4 weeks. The systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate maximum (HRmax), heart rate minimum (HRmin), left ventricular ejection fraction (LVEF), left atrial diameter (LAD), Atrial Fibrillation Severity Scale (AFSS) symptom subscale, and Memorial Symptom Assessment Scale-Heart Failure (MSAS-HF) before and after the treatment were observed and compared. In addition, adverse effects of the LL-aVNS procedure and 6-month follow-up were recorded.ResultsSBP, DBP, and HRmin were lower after the treatment than before the treatment (p < 0.05); AFSS symptom subscale scores and MSAS-HF scores after the treatment were lower before the treatment (p < 0.05); itching of the skin was observed in one case during the course of LL-aVNS; and two patients were hospitalized for acute exacerbation of chronic heart failure between 4 months and 6 months after the treatment.ConclusionLL-aVNS in patients with paroxysmal atrial fibrillation can assist in controlling blood pressure and heart rate, effectively relieving symptoms, and the treatment process is safe and feasible. |
| format | Article |
| id | doaj-art-f646f2435627414a88227710640a89ab |
| institution | Kabale University |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj-art-f646f2435627414a88227710640a89ab2025-01-29T06:45:38ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-01-011910.3389/fnins.2025.15250271525027Low-level auricular vagus nerve stimulation lowers blood pressure and heart rate in paroxysmal atrial fibrillation patients: a self-controlled studyYu Jiang0Yu Jiang1Di Su2Jingwen Xiao3Jingwen Xiao4Wenbo Cheng5Yuemei Hou6Yan Zhang7Yan Zhang8Department of Cardiovascular Medicine, Fuzhou First Hospital Affiliated With Fujian Medical University, Fuzhou, ChinaCardiovascular Disease Research Institute of Fuzhou City, Fuzhou, ChinaTeaching Experimental Center for Pharmacy, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Cardiovascular Medicine, Fuzhou First Hospital Affiliated With Fujian Medical University, Fuzhou, ChinaCardiovascular Disease Research Institute of Fuzhou City, Fuzhou, ChinaBaoshan Branch, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Geriatrics, Shanghai University of Medicine & Health Sciences Affiliated Sixth People's Hospital South Campus, Shanghai, ChinaDepartment of Cardiovascular Medicine, Fuzhou First Hospital Affiliated With Fujian Medical University, Fuzhou, ChinaCardiovascular Disease Research Institute of Fuzhou City, Fuzhou, ChinaObjectiveTo investigate the effects of low-level auricular vagus nerve stimulation (LL-aVNS) on blood pressure and heart rate in patients with paroxysmal atrial fibrillation.MethodsA total of 22 patients with paroxysmal atrial fibrillation diagnosed in Fuzhou First General Hospital Affiliated with Fujian Medical University from September 2021 to December 2022 were selected and given LL-aVNS treatment based on the original unchanged drug treatment for 4 weeks. The systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate maximum (HRmax), heart rate minimum (HRmin), left ventricular ejection fraction (LVEF), left atrial diameter (LAD), Atrial Fibrillation Severity Scale (AFSS) symptom subscale, and Memorial Symptom Assessment Scale-Heart Failure (MSAS-HF) before and after the treatment were observed and compared. In addition, adverse effects of the LL-aVNS procedure and 6-month follow-up were recorded.ResultsSBP, DBP, and HRmin were lower after the treatment than before the treatment (p < 0.05); AFSS symptom subscale scores and MSAS-HF scores after the treatment were lower before the treatment (p < 0.05); itching of the skin was observed in one case during the course of LL-aVNS; and two patients were hospitalized for acute exacerbation of chronic heart failure between 4 months and 6 months after the treatment.ConclusionLL-aVNS in patients with paroxysmal atrial fibrillation can assist in controlling blood pressure and heart rate, effectively relieving symptoms, and the treatment process is safe and feasible.https://www.frontiersin.org/articles/10.3389/fnins.2025.1525027/fullparoxysmal atrial fibrillationlow-level auricular vagus nerve stimulationautonomic nervous systemblood pressure and heart ratefeasibility and safety |
| spellingShingle | Yu Jiang Yu Jiang Di Su Jingwen Xiao Jingwen Xiao Wenbo Cheng Yuemei Hou Yan Zhang Yan Zhang Low-level auricular vagus nerve stimulation lowers blood pressure and heart rate in paroxysmal atrial fibrillation patients: a self-controlled study Frontiers in Neuroscience paroxysmal atrial fibrillation low-level auricular vagus nerve stimulation autonomic nervous system blood pressure and heart rate feasibility and safety |
| title | Low-level auricular vagus nerve stimulation lowers blood pressure and heart rate in paroxysmal atrial fibrillation patients: a self-controlled study |
| title_full | Low-level auricular vagus nerve stimulation lowers blood pressure and heart rate in paroxysmal atrial fibrillation patients: a self-controlled study |
| title_fullStr | Low-level auricular vagus nerve stimulation lowers blood pressure and heart rate in paroxysmal atrial fibrillation patients: a self-controlled study |
| title_full_unstemmed | Low-level auricular vagus nerve stimulation lowers blood pressure and heart rate in paroxysmal atrial fibrillation patients: a self-controlled study |
| title_short | Low-level auricular vagus nerve stimulation lowers blood pressure and heart rate in paroxysmal atrial fibrillation patients: a self-controlled study |
| title_sort | low level auricular vagus nerve stimulation lowers blood pressure and heart rate in paroxysmal atrial fibrillation patients a self controlled study |
| topic | paroxysmal atrial fibrillation low-level auricular vagus nerve stimulation autonomic nervous system blood pressure and heart rate feasibility and safety |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2025.1525027/full |
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