The Importance of Platelet-Derived Growth Factors as Markers of Survival and Severity of COVID-19 in Patients Undergoing Monthly Follow-Up
Platelets are the first to reach the site of tissue damage and secrete substances like platelet growth factors (GFs), which perform many different functions in the human body. Many studies suggest that GFs such as transforming GF (TGF), platelet-derived GF (PDGF), or insulin-like GF-1 (IGF-1) may be...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2024/3838845 |
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| author | Elżbieta Cecerska-Heryć Dominika Nieszpór Natalia Serwin Ewa Pius Sadowska Marta Gliźniewicz Bartłomiej Grygorcewicz Karol Serwin Anna Michalczyk Marta Budkowska Małgorzata Goszka Aleksandra Polikowska Radosław Birger Bogusław Machaliński Barbara Dołęgowska |
| author_facet | Elżbieta Cecerska-Heryć Dominika Nieszpór Natalia Serwin Ewa Pius Sadowska Marta Gliźniewicz Bartłomiej Grygorcewicz Karol Serwin Anna Michalczyk Marta Budkowska Małgorzata Goszka Aleksandra Polikowska Radosław Birger Bogusław Machaliński Barbara Dołęgowska |
| author_sort | Elżbieta Cecerska-Heryć |
| collection | DOAJ |
| description | Platelets are the first to reach the site of tissue damage and secrete substances like platelet growth factors (GFs), which perform many different functions in the human body. Many studies suggest that GFs such as transforming GF (TGF), platelet-derived GF (PDGF), or insulin-like GF-1 (IGF-1) may be markers of survival, disease severity, and post-coronavirus disease (COVID) complications. The study aimed to analyze the concentration of TGF-β, IGF-1, and PDGF-BB in COVID-19 patients compared to the control group (GK). The study group consisted of 50 patients (23 men and 27 women) at the time of COVID-19 detection, 7 days after detection, then 14 and 28 days after detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The GK comprised 48 healthy volunteers (25 women and 23 men). IGF-1, TGF-β, and PDGF-BB concentrations in blood serum by enzyme-linked immunosorbent assay (ELISA) methods. There was a statistically significant relationship between the concentration of IGF-1, TGF-β 1, and PDGF-BB in the study group (I–IV blood draw) and the GK (p<0.001). Statistical analysis showed a significant effect on the survival of COVID-19 patients on IGF-1 (p=0.013), TGF-β (p=0.013), and PGDF-BB (p=0.015) levels. The analysis showed a significant effect of COVID-19 symptom severity on IGF-1 levels (p=0.018), as well as TGF-β (p=0.044) and PDGF-BB (p=0.047). In the future, GF may serve as a predictor of disease severity and the development of new treatments for COVID-19. In later studies, the focus should be on finding the relationship of COVID-19 pathomechanism with all the parameters to understand the processes that occur in the body during SARS-CoV-2 virus infection. |
| format | Article |
| id | doaj-art-f63aa11c9a6d4082af8c35c0f4fc8be0 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-f63aa11c9a6d4082af8c35c0f4fc8be02025-02-03T06:49:25ZengWileyMediators of Inflammation1466-18612024-01-01202410.1155/2024/3838845The Importance of Platelet-Derived Growth Factors as Markers of Survival and Severity of COVID-19 in Patients Undergoing Monthly Follow-UpElżbieta Cecerska-Heryć0Dominika Nieszpór1Natalia Serwin2Ewa Pius Sadowska3Marta Gliźniewicz4Bartłomiej Grygorcewicz5Karol Serwin6Anna Michalczyk7Marta Budkowska8Małgorzata Goszka9Aleksandra Polikowska10Radosław Birger11Bogusław Machaliński12Barbara Dołęgowska13Department of Laboratory MedicineDepartment of Laboratory MedicineDepartment of Laboratory MedicineDepartment of General PathologyDepartment of Laboratory MedicineDepartment of Forensic GeneticDepartment of InfectiousDepartment of PsychiatryDepartment of Analytical MedicineDepartment of Laboratory MedicineDepartment of Laboratory MedicineDepartment of Laboratory MedicineDepartment of General PathologyDepartment of Laboratory MedicinePlatelets are the first to reach the site of tissue damage and secrete substances like platelet growth factors (GFs), which perform many different functions in the human body. Many studies suggest that GFs such as transforming GF (TGF), platelet-derived GF (PDGF), or insulin-like GF-1 (IGF-1) may be markers of survival, disease severity, and post-coronavirus disease (COVID) complications. The study aimed to analyze the concentration of TGF-β, IGF-1, and PDGF-BB in COVID-19 patients compared to the control group (GK). The study group consisted of 50 patients (23 men and 27 women) at the time of COVID-19 detection, 7 days after detection, then 14 and 28 days after detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The GK comprised 48 healthy volunteers (25 women and 23 men). IGF-1, TGF-β, and PDGF-BB concentrations in blood serum by enzyme-linked immunosorbent assay (ELISA) methods. There was a statistically significant relationship between the concentration of IGF-1, TGF-β 1, and PDGF-BB in the study group (I–IV blood draw) and the GK (p<0.001). Statistical analysis showed a significant effect on the survival of COVID-19 patients on IGF-1 (p=0.013), TGF-β (p=0.013), and PGDF-BB (p=0.015) levels. The analysis showed a significant effect of COVID-19 symptom severity on IGF-1 levels (p=0.018), as well as TGF-β (p=0.044) and PDGF-BB (p=0.047). In the future, GF may serve as a predictor of disease severity and the development of new treatments for COVID-19. In later studies, the focus should be on finding the relationship of COVID-19 pathomechanism with all the parameters to understand the processes that occur in the body during SARS-CoV-2 virus infection.http://dx.doi.org/10.1155/2024/3838845 |
| spellingShingle | Elżbieta Cecerska-Heryć Dominika Nieszpór Natalia Serwin Ewa Pius Sadowska Marta Gliźniewicz Bartłomiej Grygorcewicz Karol Serwin Anna Michalczyk Marta Budkowska Małgorzata Goszka Aleksandra Polikowska Radosław Birger Bogusław Machaliński Barbara Dołęgowska The Importance of Platelet-Derived Growth Factors as Markers of Survival and Severity of COVID-19 in Patients Undergoing Monthly Follow-Up Mediators of Inflammation |
| title | The Importance of Platelet-Derived Growth Factors as Markers of Survival and Severity of COVID-19 in Patients Undergoing Monthly Follow-Up |
| title_full | The Importance of Platelet-Derived Growth Factors as Markers of Survival and Severity of COVID-19 in Patients Undergoing Monthly Follow-Up |
| title_fullStr | The Importance of Platelet-Derived Growth Factors as Markers of Survival and Severity of COVID-19 in Patients Undergoing Monthly Follow-Up |
| title_full_unstemmed | The Importance of Platelet-Derived Growth Factors as Markers of Survival and Severity of COVID-19 in Patients Undergoing Monthly Follow-Up |
| title_short | The Importance of Platelet-Derived Growth Factors as Markers of Survival and Severity of COVID-19 in Patients Undergoing Monthly Follow-Up |
| title_sort | importance of platelet derived growth factors as markers of survival and severity of covid 19 in patients undergoing monthly follow up |
| url | http://dx.doi.org/10.1155/2024/3838845 |
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