Pharmacokinetic Properties of Baitouweng Decoction in Bama Miniature Pigs: Implications for Clinical Application in Humans
Traditional Chinese medicine (TCM) serves as a significant adjunct to chemical treatment for chronic diseases. For instance, the administration of Baitouweng decoction (BTWD) has proven effective in the treatment of ulcerative colitis. However, the limited understanding of its pharmacokinetics (PK)...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | International Journal of Analytical Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2024/5535752 |
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| author | Qianqian Xu Huilan Gao Fuqiang Zhu Wenliang Xu Yubo Wang Jinwen Xie Guangjun Guo Limei Yang Li Ma Zhiqiang Shen Jichang Li |
| author_facet | Qianqian Xu Huilan Gao Fuqiang Zhu Wenliang Xu Yubo Wang Jinwen Xie Guangjun Guo Limei Yang Li Ma Zhiqiang Shen Jichang Li |
| author_sort | Qianqian Xu |
| collection | DOAJ |
| description | Traditional Chinese medicine (TCM) serves as a significant adjunct to chemical treatment for chronic diseases. For instance, the administration of Baitouweng decoction (BTWD) has proven effective in the treatment of ulcerative colitis. However, the limited understanding of its pharmacokinetics (PK) has impeded its widespread use. Chinese Bama miniature pigs possess anatomical and physiological similarities to the human body, making them a valuable model for investigating PK properties. Consequently, the identification of PK properties in Bama miniature pigs can provide valuable insights for guiding the clinical application of BTWD in humans. To facilitate this research, a rapid and sensitive UPLC-MS/MS method has been developed for the simultaneous quantification of eleven active ingredients of BTWD in plasma. Chromatographic separation was conducted using an Acquity UPLC HSS T3 C18 column and a gradient mobile phase comprising acetonitrile and water (containing 0.1% acetic acid). The methodology was validated in accordance with the FDA Bioanalytical Method Validation Guidance for Industry. The lower limit of quantitation fell within the range of 0.60–2.01 ng/mL. Pharmacokinetic studies indicated that coptisine chloride, berberine, columbamine, phellodendrine, and obacunone exhibited low Cmax, while fraxetin, esculin, fraxin, and pulchinenoside B4 were rapidly absorbed and eliminated from the plasma. These findings have implications for the development of effective components in BTWD and the adjustment of clinical dosage regimens. |
| format | Article |
| id | doaj-art-f6354920ee1a42219135576c37495560 |
| institution | Kabale University |
| issn | 1687-8779 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Analytical Chemistry |
| spelling | doaj-art-f6354920ee1a42219135576c374955602025-02-03T05:56:55ZengWileyInternational Journal of Analytical Chemistry1687-87792024-01-01202410.1155/2024/5535752Pharmacokinetic Properties of Baitouweng Decoction in Bama Miniature Pigs: Implications for Clinical Application in HumansQianqian Xu0Huilan Gao1Fuqiang Zhu2Wenliang Xu3Yubo Wang4Jinwen Xie5Guangjun Guo6Limei Yang7Li Ma8Zhiqiang Shen9Jichang Li10Shandong Binzhou Animal Science and Veterinary Medicine AcademyBinzhou Inspection and Testing CenterBinzhou Inspection and Testing CenterSchool of Food and Advanced TechnologyDepartment of Thoracic SurgeryShandong Binzhou Animal Science and Veterinary Medicine AcademyShandong Binzhou Animal Science and Veterinary Medicine AcademyShandong Binzhou Animal Science and Veterinary Medicine AcademyShandong Binzhou Animal Science and Veterinary Medicine AcademyShandong Binzhou Animal Science and Veterinary Medicine AcademyCollege of Veterinary MedicineTraditional Chinese medicine (TCM) serves as a significant adjunct to chemical treatment for chronic diseases. For instance, the administration of Baitouweng decoction (BTWD) has proven effective in the treatment of ulcerative colitis. However, the limited understanding of its pharmacokinetics (PK) has impeded its widespread use. Chinese Bama miniature pigs possess anatomical and physiological similarities to the human body, making them a valuable model for investigating PK properties. Consequently, the identification of PK properties in Bama miniature pigs can provide valuable insights for guiding the clinical application of BTWD in humans. To facilitate this research, a rapid and sensitive UPLC-MS/MS method has been developed for the simultaneous quantification of eleven active ingredients of BTWD in plasma. Chromatographic separation was conducted using an Acquity UPLC HSS T3 C18 column and a gradient mobile phase comprising acetonitrile and water (containing 0.1% acetic acid). The methodology was validated in accordance with the FDA Bioanalytical Method Validation Guidance for Industry. The lower limit of quantitation fell within the range of 0.60–2.01 ng/mL. Pharmacokinetic studies indicated that coptisine chloride, berberine, columbamine, phellodendrine, and obacunone exhibited low Cmax, while fraxetin, esculin, fraxin, and pulchinenoside B4 were rapidly absorbed and eliminated from the plasma. These findings have implications for the development of effective components in BTWD and the adjustment of clinical dosage regimens.http://dx.doi.org/10.1155/2024/5535752 |
| spellingShingle | Qianqian Xu Huilan Gao Fuqiang Zhu Wenliang Xu Yubo Wang Jinwen Xie Guangjun Guo Limei Yang Li Ma Zhiqiang Shen Jichang Li Pharmacokinetic Properties of Baitouweng Decoction in Bama Miniature Pigs: Implications for Clinical Application in Humans International Journal of Analytical Chemistry |
| title | Pharmacokinetic Properties of Baitouweng Decoction in Bama Miniature Pigs: Implications for Clinical Application in Humans |
| title_full | Pharmacokinetic Properties of Baitouweng Decoction in Bama Miniature Pigs: Implications for Clinical Application in Humans |
| title_fullStr | Pharmacokinetic Properties of Baitouweng Decoction in Bama Miniature Pigs: Implications for Clinical Application in Humans |
| title_full_unstemmed | Pharmacokinetic Properties of Baitouweng Decoction in Bama Miniature Pigs: Implications for Clinical Application in Humans |
| title_short | Pharmacokinetic Properties of Baitouweng Decoction in Bama Miniature Pigs: Implications for Clinical Application in Humans |
| title_sort | pharmacokinetic properties of baitouweng decoction in bama miniature pigs implications for clinical application in humans |
| url | http://dx.doi.org/10.1155/2024/5535752 |
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