Release of rosmarinic acid from semisolid formulations and its penetration through human skin ex vivo
The aim of this study was to evaluate the release of rosmarinic acid (RA) from the experimental topical formulations with the Melissa officinalis L. extract and to evaluate its penetration through undamaged human skin ex vivo. The results of the in vitro release study showed that higher amounts of R...
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| Format: | Article |
| Language: | English |
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Sciendo
2015-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2015-0012 |
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| author | Stelmakienė Ada Ramanauskienė Kristina Briedis Vitalis |
| author_facet | Stelmakienė Ada Ramanauskienė Kristina Briedis Vitalis |
| author_sort | Stelmakienė Ada |
| collection | DOAJ |
| description | The aim of this study was to evaluate the release of rosmarinic acid (RA) from the experimental topical formulations with the Melissa officinalis L. extract and to evaluate its penetration through undamaged human skin ex vivo. The results of the in vitro release study showed that higher amounts of RA were released from the emulsion vehicle when lemon balm extract was added in its dry form. An inverse correlation was detected between the released amount of RA and the consistency index of the formulation. Different penetration of RA into the skin may be influenced by the characteristics of the vehicle as well as by the form of the extract. The results of penetration assessment showed that the intensity of RA penetration was influenced by its lipophilic properties: RA was accumulating in the epidermis, while the dermis served as a barrier, impeding its deeper penetration. |
| format | Article |
| id | doaj-art-f629f9d1d68e47daa1ea7193e090cd52 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2015-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-f629f9d1d68e47daa1ea7193e090cd522025-02-02T09:57:48ZengSciendoActa Pharmaceutica1846-95582015-06-0165219920510.1515/acph-2015-0012acph-2015-0012Release of rosmarinic acid from semisolid formulations and its penetration through human skin ex vivoStelmakienė Ada0Ramanauskienė Kristina1Briedis Vitalis2Department of Clinical Pharmacy Lithuanian University of Health Sciences, Kaunas, LithuaniaDepartment of Clinical Pharmacy Lithuanian University of Health Sciences, Kaunas, LithuaniaDepartment of Clinical Pharmacy Lithuanian University of Health Sciences, Kaunas, LithuaniaThe aim of this study was to evaluate the release of rosmarinic acid (RA) from the experimental topical formulations with the Melissa officinalis L. extract and to evaluate its penetration through undamaged human skin ex vivo. The results of the in vitro release study showed that higher amounts of RA were released from the emulsion vehicle when lemon balm extract was added in its dry form. An inverse correlation was detected between the released amount of RA and the consistency index of the formulation. Different penetration of RA into the skin may be influenced by the characteristics of the vehicle as well as by the form of the extract. The results of penetration assessment showed that the intensity of RA penetration was influenced by its lipophilic properties: RA was accumulating in the epidermis, while the dermis served as a barrier, impeding its deeper penetration.https://doi.org/10.1515/acph-2015-0012human skin penetrationrosmarinic acidrheologyrelease |
| spellingShingle | Stelmakienė Ada Ramanauskienė Kristina Briedis Vitalis Release of rosmarinic acid from semisolid formulations and its penetration through human skin ex vivo Acta Pharmaceutica human skin penetration rosmarinic acid rheology release |
| title | Release of rosmarinic acid from semisolid formulations and its penetration through human skin ex vivo |
| title_full | Release of rosmarinic acid from semisolid formulations and its penetration through human skin ex vivo |
| title_fullStr | Release of rosmarinic acid from semisolid formulations and its penetration through human skin ex vivo |
| title_full_unstemmed | Release of rosmarinic acid from semisolid formulations and its penetration through human skin ex vivo |
| title_short | Release of rosmarinic acid from semisolid formulations and its penetration through human skin ex vivo |
| title_sort | release of rosmarinic acid from semisolid formulations and its penetration through human skin ex vivo |
| topic | human skin penetration rosmarinic acid rheology release |
| url | https://doi.org/10.1515/acph-2015-0012 |
| work_keys_str_mv | AT stelmakieneada releaseofrosmarinicacidfromsemisolidformulationsanditspenetrationthroughhumanskinexvivo AT ramanauskienekristina releaseofrosmarinicacidfromsemisolidformulationsanditspenetrationthroughhumanskinexvivo AT briedisvitalis releaseofrosmarinicacidfromsemisolidformulationsanditspenetrationthroughhumanskinexvivo |