Quantitative Analysis of Lorazepam in Pharmaceutical Formulation Through FTIR Spectroscopy
A Fourier transform infrared (FTIR) spectrophotometric method was development for the rapid, direct measurement of lorazepam in different pharmaceutical products. The method involves the off-line extraction of lorazepam with sonication and direct determination in the extract through peak height meas...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2012/914974 |
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| author | Elaheh Konoz Amir Hossein Mohsen Sarrafi Marjaneh Samadizadeh Samaneh Boreiri |
| author_facet | Elaheh Konoz Amir Hossein Mohsen Sarrafi Marjaneh Samadizadeh Samaneh Boreiri |
| author_sort | Elaheh Konoz |
| collection | DOAJ |
| description | A Fourier transform infrared (FTIR) spectrophotometric method was development for the rapid, direct measurement of lorazepam in different pharmaceutical products. The method involves the off-line extraction of lorazepam with sonication and direct determination in the extract through peak height measurement in the 1704 cm-1 using a baseline correction between 1850 and 1550 cm-1. For standardization an external calibration line established from standard solutions of lorazepam in chloroform were used. The method provides a limit of detection of 0.0030 mg per tablet (n=5), a relative standard deviation (RSD) of 2.65% for 5 independent measurement of standard solution at a concentration level of 1 mgg-1. Result obtained by FTIR agrees with those obtained by a reference methodology based on ultraviolet spectrometry and thus the developed procedure offers a good alternative for the determination of lorazepam in commercial products. |
| format | Article |
| id | doaj-art-f6290272e33e4600980fa42ac6361fba |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-f6290272e33e4600980fa42ac6361fba2025-02-03T01:27:39ZengWileyE-Journal of Chemistry0973-49452090-98102012-01-01942232223810.1155/2012/914974Quantitative Analysis of Lorazepam in Pharmaceutical Formulation Through FTIR SpectroscopyElaheh Konoz0Amir Hossein Mohsen Sarrafi1Marjaneh Samadizadeh2Samaneh Boreiri3Department of Chemistry, Faculty of Science, Islamic Azad University (Central Tehran Branch), Tehran, IranDepartment of Chemistry, Faculty of Science, Islamic Azad University (Central Tehran Branch), Tehran, IranDepartment of Chemistry, Faculty of Science, Islamic Azad University (Central Tehran Branch), Tehran, IranDepartment of Chemistry, Faculty of Science, Islamic Azad University (Central Tehran Branch), Tehran, IranA Fourier transform infrared (FTIR) spectrophotometric method was development for the rapid, direct measurement of lorazepam in different pharmaceutical products. The method involves the off-line extraction of lorazepam with sonication and direct determination in the extract through peak height measurement in the 1704 cm-1 using a baseline correction between 1850 and 1550 cm-1. For standardization an external calibration line established from standard solutions of lorazepam in chloroform were used. The method provides a limit of detection of 0.0030 mg per tablet (n=5), a relative standard deviation (RSD) of 2.65% for 5 independent measurement of standard solution at a concentration level of 1 mgg-1. Result obtained by FTIR agrees with those obtained by a reference methodology based on ultraviolet spectrometry and thus the developed procedure offers a good alternative for the determination of lorazepam in commercial products.http://dx.doi.org/10.1155/2012/914974 |
| spellingShingle | Elaheh Konoz Amir Hossein Mohsen Sarrafi Marjaneh Samadizadeh Samaneh Boreiri Quantitative Analysis of Lorazepam in Pharmaceutical Formulation Through FTIR Spectroscopy E-Journal of Chemistry |
| title | Quantitative Analysis of Lorazepam in Pharmaceutical Formulation Through FTIR Spectroscopy |
| title_full | Quantitative Analysis of Lorazepam in Pharmaceutical Formulation Through FTIR Spectroscopy |
| title_fullStr | Quantitative Analysis of Lorazepam in Pharmaceutical Formulation Through FTIR Spectroscopy |
| title_full_unstemmed | Quantitative Analysis of Lorazepam in Pharmaceutical Formulation Through FTIR Spectroscopy |
| title_short | Quantitative Analysis of Lorazepam in Pharmaceutical Formulation Through FTIR Spectroscopy |
| title_sort | quantitative analysis of lorazepam in pharmaceutical formulation through ftir spectroscopy |
| url | http://dx.doi.org/10.1155/2012/914974 |
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