Leigh's Disease: The Acute Clinical Course of a Two-Year-Old Child with Subacute Necrotizing Encephalomyelopathy
We report the untypical clinical course of a previously healthy two-year-old girl, who died suddenly and unexpectedly after an episode of vomiting. At forensic autopsy no other pathological findings could be diagnosed than multiple reddish, sunken areas in brain stem, mesencephalon, and pons. Histol...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2010/986302 |
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| author | Bettina Zinka Andreas Buettner Matthias Graw |
| author_facet | Bettina Zinka Andreas Buettner Matthias Graw |
| author_sort | Bettina Zinka |
| collection | DOAJ |
| description | We report the untypical clinical course of a previously healthy two-year-old girl, who died suddenly and unexpectedly after an episode of vomiting. At forensic autopsy no other pathological findings could be diagnosed than multiple reddish, sunken areas in brain stem, mesencephalon, and pons. Histologically they presented as areas of spongiosis of the neuropil with prominent endothelial hyperplasia and vascular proliferation whereas nerve cells were well preserved.
On the basis of the characteristic neuropathological findings in combination with the age of the child, we had to take into consideration that the child might have died from subacute necrotizing encephalomyelopathy (Leigh's Disease) despite the untypical, fulminant clinical course. |
| format | Article |
| id | doaj-art-f61c7e2b8a0149f287decf3889305275 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-f61c7e2b8a0149f287decf38893052752025-02-03T01:30:49ZengWileyCase Reports in Medicine1687-96271687-96352010-01-01201010.1155/2010/986302986302Leigh's Disease: The Acute Clinical Course of a Two-Year-Old Child with Subacute Necrotizing EncephalomyelopathyBettina Zinka0Andreas Buettner1Matthias Graw2Institute of Legal Medicine, University of Munich, Nussbaumstraße 26, 80336 Munich, GermanyInstitute of Legal Medicine, University of Munich, Nussbaumstraße 26, 80336 Munich, GermanyInstitute of Legal Medicine, University of Munich, Nussbaumstraße 26, 80336 Munich, GermanyWe report the untypical clinical course of a previously healthy two-year-old girl, who died suddenly and unexpectedly after an episode of vomiting. At forensic autopsy no other pathological findings could be diagnosed than multiple reddish, sunken areas in brain stem, mesencephalon, and pons. Histologically they presented as areas of spongiosis of the neuropil with prominent endothelial hyperplasia and vascular proliferation whereas nerve cells were well preserved. On the basis of the characteristic neuropathological findings in combination with the age of the child, we had to take into consideration that the child might have died from subacute necrotizing encephalomyelopathy (Leigh's Disease) despite the untypical, fulminant clinical course.http://dx.doi.org/10.1155/2010/986302 |
| spellingShingle | Bettina Zinka Andreas Buettner Matthias Graw Leigh's Disease: The Acute Clinical Course of a Two-Year-Old Child with Subacute Necrotizing Encephalomyelopathy Case Reports in Medicine |
| title | Leigh's Disease: The Acute Clinical Course of a Two-Year-Old Child with Subacute Necrotizing Encephalomyelopathy |
| title_full | Leigh's Disease: The Acute Clinical Course of a Two-Year-Old Child with Subacute Necrotizing Encephalomyelopathy |
| title_fullStr | Leigh's Disease: The Acute Clinical Course of a Two-Year-Old Child with Subacute Necrotizing Encephalomyelopathy |
| title_full_unstemmed | Leigh's Disease: The Acute Clinical Course of a Two-Year-Old Child with Subacute Necrotizing Encephalomyelopathy |
| title_short | Leigh's Disease: The Acute Clinical Course of a Two-Year-Old Child with Subacute Necrotizing Encephalomyelopathy |
| title_sort | leigh s disease the acute clinical course of a two year old child with subacute necrotizing encephalomyelopathy |
| url | http://dx.doi.org/10.1155/2010/986302 |
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