A more accurate relationship between serum androgen and metabolism among healthy, nonobese, reproductive-age women based on liquid chromatography-tandem mass spectrometry
This study explored a more precise association between androgens and glycolipid metabolism in healthy women of different ages. Body mass index (BMI), waist circumference (WC), and waist-to-hip ratio were used as body fat indicators. High-density lipoprotein (HDL), low-density lipoprotein, triglyceri...
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| Format: | Article |
| Language: | English |
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The Japan Endocrine Society
2024-01-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/71/1/71_EJ23-0451/_html/-char/en |
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| author | Sha Ye Yepei Huang Yi Lu Xiaoyan Li Meiling Ye Hongyu Lu Junhua Shi Jian Huang Hong Cai |
| author_facet | Sha Ye Yepei Huang Yi Lu Xiaoyan Li Meiling Ye Hongyu Lu Junhua Shi Jian Huang Hong Cai |
| author_sort | Sha Ye |
| collection | DOAJ |
| description | This study explored a more precise association between androgens and glycolipid metabolism in healthy women of different ages. Body mass index (BMI), waist circumference (WC), and waist-to-hip ratio were used as body fat indicators. High-density lipoprotein (HDL), low-density lipoprotein, triglycerides, and total cholesterol were used as lipid markers. Fasting blood glucose (FBG), fasting insulin, and the homeostatic model assessment of insulin resistance were used to assess insulin resistance and glucose metabolism. Liquid chromatography-tandem mass spectrometry was used to measure androgen indicators, including testosterone, sex hormone-binding globulin (SHBG), free testosterone (FT), dihydrotestosterone (DHT), androstenedione (A4), dehydroepiandrosterone (DHEA), and dehydroepiandrosterone sulfate (DHEAS). DHEAS levels varied across age groups. Correlation analyses with Spearman’s coefficient showed that the free androgen index correlated positively with WC (p = 0.040), FT correlated positively with BMI (p = 0.033) and WC (p = 0.049), SHBG correlated positively with HDL (p = 0.013), and A4 correlated positively with FBG (p = 0.017). Multiple linear regression analysis showed that among healthful women aged 36–40 years, A4 increased with FBG, and SHBG increased with HDL. Even within healthy, nonobese women, lipid and glucose metabolism were robustly correlated with androgens. Yearly metabolic assessments are necessary, particularly for FBG and HDL, since these markers can predict the likelihood of hyperandrogenemia, enabling timely interventions. |
| format | Article |
| id | doaj-art-f60f1340323c4932bb9dcb370a53de6e |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-f60f1340323c4932bb9dcb370a53de6e2025-01-22T06:31:09ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402024-01-01711455410.1507/endocrj.EJ23-0451endocrjA more accurate relationship between serum androgen and metabolism among healthy, nonobese, reproductive-age women based on liquid chromatography-tandem mass spectrometrySha Ye0Yepei Huang1Yi Lu2Xiaoyan Li3Meiling Ye4Hongyu Lu5Junhua Shi6Jian Huang7Hong Cai8The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Zhejiang 310053, ChinaThe Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Zhejiang 310053, ChinaThe Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Zhejiang 310053, ChinaYuhang District First People’s Hospital, Zhejiang 310053, ChinaHangzhou Lin’an District No.4 People’s Hospital, Zhejiang 310053, ChinaDepartment of Obstetrics and Gynecology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Zhejiang 310008, ChinaDepartment of Obstetrics and Gynecology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Zhejiang 310008, ChinaDepartment of Obstetrics and Gynecology, Hangzhou Women’s Hospital, Zhejiang 310008, ChinaDepartment of Obstetrics and Gynecology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Zhejiang 310008, ChinaThis study explored a more precise association between androgens and glycolipid metabolism in healthy women of different ages. Body mass index (BMI), waist circumference (WC), and waist-to-hip ratio were used as body fat indicators. High-density lipoprotein (HDL), low-density lipoprotein, triglycerides, and total cholesterol were used as lipid markers. Fasting blood glucose (FBG), fasting insulin, and the homeostatic model assessment of insulin resistance were used to assess insulin resistance and glucose metabolism. Liquid chromatography-tandem mass spectrometry was used to measure androgen indicators, including testosterone, sex hormone-binding globulin (SHBG), free testosterone (FT), dihydrotestosterone (DHT), androstenedione (A4), dehydroepiandrosterone (DHEA), and dehydroepiandrosterone sulfate (DHEAS). DHEAS levels varied across age groups. Correlation analyses with Spearman’s coefficient showed that the free androgen index correlated positively with WC (p = 0.040), FT correlated positively with BMI (p = 0.033) and WC (p = 0.049), SHBG correlated positively with HDL (p = 0.013), and A4 correlated positively with FBG (p = 0.017). Multiple linear regression analysis showed that among healthful women aged 36–40 years, A4 increased with FBG, and SHBG increased with HDL. Even within healthy, nonobese women, lipid and glucose metabolism were robustly correlated with androgens. Yearly metabolic assessments are necessary, particularly for FBG and HDL, since these markers can predict the likelihood of hyperandrogenemia, enabling timely interventions.https://www.jstage.jst.go.jp/article/endocrj/71/1/71_EJ23-0451/_html/-char/enandrogenblood lipidsinsulin resistancemetabolismliquid chromatography with tandem mass spectrometry |
| spellingShingle | Sha Ye Yepei Huang Yi Lu Xiaoyan Li Meiling Ye Hongyu Lu Junhua Shi Jian Huang Hong Cai A more accurate relationship between serum androgen and metabolism among healthy, nonobese, reproductive-age women based on liquid chromatography-tandem mass spectrometry Endocrine Journal androgen blood lipids insulin resistance metabolism liquid chromatography with tandem mass spectrometry |
| title | A more accurate relationship between serum androgen and metabolism among healthy, nonobese, reproductive-age women based on liquid chromatography-tandem mass spectrometry |
| title_full | A more accurate relationship between serum androgen and metabolism among healthy, nonobese, reproductive-age women based on liquid chromatography-tandem mass spectrometry |
| title_fullStr | A more accurate relationship between serum androgen and metabolism among healthy, nonobese, reproductive-age women based on liquid chromatography-tandem mass spectrometry |
| title_full_unstemmed | A more accurate relationship between serum androgen and metabolism among healthy, nonobese, reproductive-age women based on liquid chromatography-tandem mass spectrometry |
| title_short | A more accurate relationship between serum androgen and metabolism among healthy, nonobese, reproductive-age women based on liquid chromatography-tandem mass spectrometry |
| title_sort | more accurate relationship between serum androgen and metabolism among healthy nonobese reproductive age women based on liquid chromatography tandem mass spectrometry |
| topic | androgen blood lipids insulin resistance metabolism liquid chromatography with tandem mass spectrometry |
| url | https://www.jstage.jst.go.jp/article/endocrj/71/1/71_EJ23-0451/_html/-char/en |
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