Regulatory roles of three-dimensional structures of chromatin domains

Regulatory roles of three-dimensional structures of chromatin domains

Abstract Background Transcriptional enhancers usually, but not always, regulate genes within the same topologically associating domain (TAD). We hypothesize that this incomplete insulation is partially due to three-dimensional structures of corresponding chromatin domains in individual cells: wherea...

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Main Authors: Kelly Yichen Li, Qin Cao, Savio Ho-Chit Chow, Chiara Nicoletti, Pier Lorenzo Puri, Huating Wang, Danny Leung, Kevin Y. Yip
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Genome Biology
Online Access:https://doi.org/10.1186/s13059-025-03659-7
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