The role of malnutrition on outcomes of multisystem inflammatory syndrome in children (MIS-C) due to COVID-19
Background. Malnutrition increases the complications and mortality in critically-ill children. We performed a retrospective analysis to define the impact of malnutrition on the outcomes of multisystem inflammatory syndrome in children (MIS-C) due to COVID-19. Methods. Patients with MIS-C were eva...
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Hacettepe University Institute of Child Health
2024-05-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/4586 |
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| author | Tutku Soyer Kübra Aykaç Gözde Özer Yasemin Özsürekçi H. Nursun Özcan Kaya Yorgancı Osman Abbasoğlu |
| author_facet | Tutku Soyer Kübra Aykaç Gözde Özer Yasemin Özsürekçi H. Nursun Özcan Kaya Yorgancı Osman Abbasoğlu |
| author_sort | Tutku Soyer |
| collection | DOAJ |
| description |
Background. Malnutrition increases the complications and mortality in critically-ill children. We performed a retrospective analysis to define the impact of malnutrition on the outcomes of multisystem inflammatory syndrome in children (MIS-C) due to COVID-19.
Methods. Patients with MIS-C were evaluated for demographic features, anthropometric parameters, clinical findings and outcomes. Patients with z scores of body mass index (> 5 years) and weight-for-age (< 5 years) < -2 were considered malnourished. Sarcopenia was defined by total psoas muscle area (tPMA), calculated on abdominal computed tomography (CT) at the level of L3 and L4 vertebrae. The z scores <- 2 for tPMA were considered sarcopenia. The results of patients with and without malnutrition were compared.
Results. Twenty-seven patients were included. Forty-four percent (n=12) of patients had malnutrition. Malnutrition was classified as mild to moderate (1/3), severe (1/3) and overweight (1/3). Eighty-two % of cases had acute malnutrition. Among MIS-C symptom criteria, rash was significantly higher in children with malnutrition (p<0.05). Laboratory investigations showed higher ferritin levels in patients with malnutrition (p<0.05). The median tPMA and sarcopenia were significantly higher in patients with malnutrition when compared to patients without malnutrition (42% vs 7%, p<0.05). The oral feeding time, complication rates, and length of hospital stay were similar in both groups (p>0.05).
Conclusion. Children with MIS-C already had mild to severe malnutrition at admission. Rash and higher ferritin levels were more common in patients with malnutrition. In addition to anthropometric parameters, sarcopenia calculated using tPMA can be used to predict malnutrition in critically-ill children.
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| format | Article |
| id | doaj-art-f5f95bca74fc40f78c1a4e965e2e8f00 |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-f5f95bca74fc40f78c1a4e965e2e8f002025-08-20T02:00:47ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212024-05-0166210.24953/turkjpediatr.2024.4586The role of malnutrition on outcomes of multisystem inflammatory syndrome in children (MIS-C) due to COVID-19Tutku Soyer0https://orcid.org/0000-0003-1505-6042Kübra Aykaç1https://orcid.org/0000-0002-0974-4765Gözde Özer2https://orcid.org/0000-0001-5545-2512Yasemin Özsürekçi3https://orcid.org/0000-0001-8662-6909H. Nursun Özcan4https://orcid.org/0000-0003-4756-4359Kaya Yorgancı5https://orcid.org/0000-0003-4346-289XOsman Abbasoğlu6https://orcid.org/0000-0001-7069-929XDepartment of Pediatric Surgery, Faculty of Medicine, Hacettepe University, Ankara, TürkiyeDepartment of Pediatric Infectious Diseases, Faculty of Medicine, Hacettepe University, Ankara, TürkiyeDepartment of Pediatric Radiology, Faculty of Medicine, Hacettepe University, Ankara, TürkiyeDepartment of Pediatric Infectious Diseases, Faculty of Medicine, Hacettepe University, Ankara, TürkiyeDepartment of Pediatric Radiology, Faculty of Medicine, Hacettepe University, Ankara, TürkiyeDepartment of General Surgery, Faculty of Medicine, Hacettepe University, Ankara, TürkiyeDepartment of General Surgery, Faculty of Medicine, Hacettepe University, Ankara, Türkiye Background. Malnutrition increases the complications and mortality in critically-ill children. We performed a retrospective analysis to define the impact of malnutrition on the outcomes of multisystem inflammatory syndrome in children (MIS-C) due to COVID-19. Methods. Patients with MIS-C were evaluated for demographic features, anthropometric parameters, clinical findings and outcomes. Patients with z scores of body mass index (> 5 years) and weight-for-age (< 5 years) < -2 were considered malnourished. Sarcopenia was defined by total psoas muscle area (tPMA), calculated on abdominal computed tomography (CT) at the level of L3 and L4 vertebrae. The z scores <- 2 for tPMA were considered sarcopenia. The results of patients with and without malnutrition were compared. Results. Twenty-seven patients were included. Forty-four percent (n=12) of patients had malnutrition. Malnutrition was classified as mild to moderate (1/3), severe (1/3) and overweight (1/3). Eighty-two % of cases had acute malnutrition. Among MIS-C symptom criteria, rash was significantly higher in children with malnutrition (p<0.05). Laboratory investigations showed higher ferritin levels in patients with malnutrition (p<0.05). The median tPMA and sarcopenia were significantly higher in patients with malnutrition when compared to patients without malnutrition (42% vs 7%, p<0.05). The oral feeding time, complication rates, and length of hospital stay were similar in both groups (p>0.05). Conclusion. Children with MIS-C already had mild to severe malnutrition at admission. Rash and higher ferritin levels were more common in patients with malnutrition. In addition to anthropometric parameters, sarcopenia calculated using tPMA can be used to predict malnutrition in critically-ill children. https://turkjpediatr.org/article/view/4586malnutritionCOVID-19multisystem inflammatory syndromesarcopenia |
| spellingShingle | Tutku Soyer Kübra Aykaç Gözde Özer Yasemin Özsürekçi H. Nursun Özcan Kaya Yorgancı Osman Abbasoğlu The role of malnutrition on outcomes of multisystem inflammatory syndrome in children (MIS-C) due to COVID-19 The Turkish Journal of Pediatrics malnutrition COVID-19 multisystem inflammatory syndrome sarcopenia |
| title | The role of malnutrition on outcomes of multisystem inflammatory syndrome in children (MIS-C) due to COVID-19 |
| title_full | The role of malnutrition on outcomes of multisystem inflammatory syndrome in children (MIS-C) due to COVID-19 |
| title_fullStr | The role of malnutrition on outcomes of multisystem inflammatory syndrome in children (MIS-C) due to COVID-19 |
| title_full_unstemmed | The role of malnutrition on outcomes of multisystem inflammatory syndrome in children (MIS-C) due to COVID-19 |
| title_short | The role of malnutrition on outcomes of multisystem inflammatory syndrome in children (MIS-C) due to COVID-19 |
| title_sort | role of malnutrition on outcomes of multisystem inflammatory syndrome in children mis c due to covid 19 |
| topic | malnutrition COVID-19 multisystem inflammatory syndrome sarcopenia |
| url | https://turkjpediatr.org/article/view/4586 |
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