The cellular and extracellular proteomic signature of human dopaminergic neurons carrying the LRRK2 G2019S mutation

The cellular and extracellular proteomic signature of human dopaminergic neurons carrying the LRRK2 G2019S mutation

BackgroundExtracellular vesicles are easily accessible in various biofluids and allow the assessment of disease-related changes in the proteome. This has made them a promising target for biomarker studies, especially in the field of neurodegeneration where access to diseased tissue is very limited....

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Bibliographic Details
Main Authors: Felix Knab, Giambattista Guaitoli, Mohamed Ali Jarboui, Felix von Zweydorf, Fatma Busra Isik, Franziska Klose, Anto Praveen Rajkumar, Thomas Gasser, Christian Johannes Gloeckner
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Neuroscience
Subjects:
extracellular vesicle
biomarker
induced pluripotent stem cell
LRRK2
Parkinson’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2024.1502246/full
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