Diagnostic Pitfalls in Newborns and Babies with Blisters and Erosions
Establishing the correct diagnosis in newborns presenting with blisters and erosions is not always a straightforward process. Many different disease entities including acquired (i.e., infectious, immunobullous, traumatic) and inherited disorders have to be taken into consideration. Similarities in c...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2009/320403 |
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| author | Elke Nischler Alfred Klausegger Clemens Hüttner Gabriele Pohla-Gubo Anja Diem Johann W. Bauer Helmut Hintner |
| author_facet | Elke Nischler Alfred Klausegger Clemens Hüttner Gabriele Pohla-Gubo Anja Diem Johann W. Bauer Helmut Hintner |
| author_sort | Elke Nischler |
| collection | DOAJ |
| description | Establishing the correct diagnosis in newborns presenting with blisters and erosions is not always a straightforward process. Many different disease entities including acquired (i.e., infectious, immunobullous, traumatic) and inherited disorders have to be taken into consideration. Similarities in clinical appearance, colonization and/or superinfections of preexisting skin lesions, as well as the absence of late changes in the neonate often pose significant diagnostic challenges. In this paper we discuss by giving examples the process of making an accurate diagnosis of blistering skin diseases in the neonatal period on the basis of a diagnostic algorithm. In addition, we provide an overview of the rational use and the limitations of laboratory procedures such as microbial testing, routine light microscopy, immunofluorescence antigen mapping, transmission electron microscopy, and molecular genetic analysis. |
| format | Article |
| id | doaj-art-f5e4da7e3b5348539c8a2c07a50310b3 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-f5e4da7e3b5348539c8a2c07a50310b32025-02-03T01:27:36ZengWileyDermatology Research and Practice1687-61051687-61132009-01-01200910.1155/2009/320403320403Diagnostic Pitfalls in Newborns and Babies with Blisters and ErosionsElke Nischler0Alfred Klausegger1Clemens Hüttner2Gabriele Pohla-Gubo3Anja Diem4Johann W. Bauer5Helmut Hintner6Department of Dermatology, eb-house Austria, Paracelsus Private Medical University Salzburg, Muellner Hauptstraße 48, 5020 Salzburg, AustriaDepartment of Dermatology, eb-house Austria, Paracelsus Private Medical University Salzburg, Muellner Hauptstraße 48, 5020 Salzburg, AustriaDepartment of Dermatology, eb-house Austria, Paracelsus Private Medical University Salzburg, Muellner Hauptstraße 48, 5020 Salzburg, AustriaDepartment of Dermatology, eb-house Austria, Paracelsus Private Medical University Salzburg, Muellner Hauptstraße 48, 5020 Salzburg, AustriaDepartment of Dermatology, eb-house Austria, Paracelsus Private Medical University Salzburg, Muellner Hauptstraße 48, 5020 Salzburg, AustriaDepartment of Dermatology, eb-house Austria, Paracelsus Private Medical University Salzburg, Muellner Hauptstraße 48, 5020 Salzburg, AustriaDepartment of Dermatology, eb-house Austria, Paracelsus Private Medical University Salzburg, Muellner Hauptstraße 48, 5020 Salzburg, AustriaEstablishing the correct diagnosis in newborns presenting with blisters and erosions is not always a straightforward process. Many different disease entities including acquired (i.e., infectious, immunobullous, traumatic) and inherited disorders have to be taken into consideration. Similarities in clinical appearance, colonization and/or superinfections of preexisting skin lesions, as well as the absence of late changes in the neonate often pose significant diagnostic challenges. In this paper we discuss by giving examples the process of making an accurate diagnosis of blistering skin diseases in the neonatal period on the basis of a diagnostic algorithm. In addition, we provide an overview of the rational use and the limitations of laboratory procedures such as microbial testing, routine light microscopy, immunofluorescence antigen mapping, transmission electron microscopy, and molecular genetic analysis.http://dx.doi.org/10.1155/2009/320403 |
| spellingShingle | Elke Nischler Alfred Klausegger Clemens Hüttner Gabriele Pohla-Gubo Anja Diem Johann W. Bauer Helmut Hintner Diagnostic Pitfalls in Newborns and Babies with Blisters and Erosions Dermatology Research and Practice |
| title | Diagnostic Pitfalls in Newborns and Babies with Blisters and Erosions |
| title_full | Diagnostic Pitfalls in Newborns and Babies with Blisters and Erosions |
| title_fullStr | Diagnostic Pitfalls in Newborns and Babies with Blisters and Erosions |
| title_full_unstemmed | Diagnostic Pitfalls in Newborns and Babies with Blisters and Erosions |
| title_short | Diagnostic Pitfalls in Newborns and Babies with Blisters and Erosions |
| title_sort | diagnostic pitfalls in newborns and babies with blisters and erosions |
| url | http://dx.doi.org/10.1155/2009/320403 |
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