A study on the effect of blue light on kidney stone formation in rats via the brain-kidney axis
Abstract Kidney stones, a common urological disease, may involve the brain-kidney axis in their formation, though the specific mechanism remains unclear. This study aimed to investigate the effects of blue light on relevant metabolic indicators and oxidative stress status in rats with kidney stones...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-85586-y |
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| author | Dao-Cheng Fang Yuan-Yuan Hu Chao Wang Jie Fan Hui Wen |
| author_facet | Dao-Cheng Fang Yuan-Yuan Hu Chao Wang Jie Fan Hui Wen |
| author_sort | Dao-Cheng Fang |
| collection | DOAJ |
| description | Abstract Kidney stones, a common urological disease, may involve the brain-kidney axis in their formation, though the specific mechanism remains unclear. This study aimed to investigate the effects of blue light on relevant metabolic indicators and oxidative stress status in rats with kidney stones through the brain-kidney axis. A rat model of kidney stones was established by administering 1% ethylene glycol and 2% ammonium chloride. Subsequently, blue light intervention was applied, and the outcomes were compared with those of a control group of normal rats. Our findings revealed that rats with kidney stones receiving blue light intervention exhibited significantly increased levels of antidiuretic hormone, intensified oxidative stress response, and augmented stone formation compared to kidney stone rats without blue light intervention. However, in normal rats, blue light intervention did not cause significant changes in these indicators. In summary, this study indicates that under pathological conditions, blue light may promote the secretion of antidiuretic hormone in serum and enhance oxidative stress response in renal tissues by affecting the brain-kidney axis, thereby accelerating the formation of kidney stones in rats. |
| format | Article |
| id | doaj-art-f5e31cb8e37b4cc6a6b331027582e1a8 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-f5e31cb8e37b4cc6a6b331027582e1a82025-02-02T12:19:38ZengNature PortfolioScientific Reports2045-23222025-01-011511710.1038/s41598-025-85586-yA study on the effect of blue light on kidney stone formation in rats via the brain-kidney axisDao-Cheng Fang0Yuan-Yuan Hu1Chao Wang2Jie Fan3Hui Wen4Department of Urology, Songjiang hospital affiliated to Shanghai jiaotong university school of medicineDepartment of General Practice, Songjiang hospital affiliated to Shanghai jiaotong university school of medicineDepartment of Urology, Songjiang hospital affiliated to Shanghai jiaotong university school of medicineDepartment of Urology, School of Medicine, Shanghai First People’s Hospital, Shanghai Jiaotong UniversityDepartment of Urology, Songjiang hospital affiliated to Shanghai jiaotong university school of medicineAbstract Kidney stones, a common urological disease, may involve the brain-kidney axis in their formation, though the specific mechanism remains unclear. This study aimed to investigate the effects of blue light on relevant metabolic indicators and oxidative stress status in rats with kidney stones through the brain-kidney axis. A rat model of kidney stones was established by administering 1% ethylene glycol and 2% ammonium chloride. Subsequently, blue light intervention was applied, and the outcomes were compared with those of a control group of normal rats. Our findings revealed that rats with kidney stones receiving blue light intervention exhibited significantly increased levels of antidiuretic hormone, intensified oxidative stress response, and augmented stone formation compared to kidney stone rats without blue light intervention. However, in normal rats, blue light intervention did not cause significant changes in these indicators. In summary, this study indicates that under pathological conditions, blue light may promote the secretion of antidiuretic hormone in serum and enhance oxidative stress response in renal tissues by affecting the brain-kidney axis, thereby accelerating the formation of kidney stones in rats.https://doi.org/10.1038/s41598-025-85586-yBlue lightBrain-kidney axisKidney stonesOxidative stress |
| spellingShingle | Dao-Cheng Fang Yuan-Yuan Hu Chao Wang Jie Fan Hui Wen A study on the effect of blue light on kidney stone formation in rats via the brain-kidney axis Scientific Reports Blue light Brain-kidney axis Kidney stones Oxidative stress |
| title | A study on the effect of blue light on kidney stone formation in rats via the brain-kidney axis |
| title_full | A study on the effect of blue light on kidney stone formation in rats via the brain-kidney axis |
| title_fullStr | A study on the effect of blue light on kidney stone formation in rats via the brain-kidney axis |
| title_full_unstemmed | A study on the effect of blue light on kidney stone formation in rats via the brain-kidney axis |
| title_short | A study on the effect of blue light on kidney stone formation in rats via the brain-kidney axis |
| title_sort | study on the effect of blue light on kidney stone formation in rats via the brain kidney axis |
| topic | Blue light Brain-kidney axis Kidney stones Oxidative stress |
| url | https://doi.org/10.1038/s41598-025-85586-y |
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