The GPCR antagonist PPTN synergizes with caspofungin providing increased fungicidal activity against Aspergillus fumigatus

The GPCR antagonist PPTN synergizes with caspofungin providing increased fungicidal activity against Aspergillus fumigatus

ABSTRACT Fungal pathogens pose a serious threat to human health, with Candida and Aspergillus spp. representing some of the most significant opportunistic invaders. Aspergillus fumigatus causes aspergillosis, one of the most prevalent fungal diseases of humans. There is a limited number of drugs ava...

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Main Authors: Thaila Fernanda dos Reis, Endrews Delbaje, Camila Figueiredo Pinzan, Rafael Bastos, Suzanne Ackloo, Sara Fallah, Bradley Laflamme, Nicole Robbins, Leah E. Cowen, Gustavo H. Goldman
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:Microbiology Spectrum
Subjects:
Aspergillus fumigatus
caspofungin
PPTN
Candida spp
Cryptococcus neoformans
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03318-24
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https://journals.asm.org/doi/10.1128/spectrum.03318-24

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