Quantitative Liver Function Tests: A Realizable Goal?
A variety of tests has been used to assess liver function and predict hepatic functional reserve in patients with liver disease. These tests comprise clinical assessment, simple biochemical measurements and so-called ‘quantitative’ tests of liver function, ie, elimination rate measurements of exogen...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1991-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1991/671534 |
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| _version_ | 1832553233447387136 |
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| author | Denis J Morgan Susan L Elliott Hany Ghabrial Richard A Smallwood |
| author_facet | Denis J Morgan Susan L Elliott Hany Ghabrial Richard A Smallwood |
| author_sort | Denis J Morgan |
| collection | DOAJ |
| description | A variety of tests has been used to assess liver function and predict hepatic functional reserve in patients with liver disease. These tests comprise clinical assessment, simple biochemical measurements and so-called ‘quantitative’ tests of liver function, ie, elimination rate measurements of exogenous markers such as drugs and other compounds. So far no single test or group of tests has proved to be a sufficiently sensitive and accurate measure of overall hepatic function across the whole spectrum of liver disease. This may he due to diversity in the hepatic handling of these compounds and in changes in architecture, hemodynamics and cell function in liver disease. The absence of a satisfactory test emphasizes the value of clinical assessments (eg, the Child-Turcotte or Child-Pugh classifications), because of their relative simplicity. |
| format | Article |
| id | doaj-art-f5d8c44d25564277af9750a37b5577bd |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1991-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-f5d8c44d25564277af9750a37b5577bd2025-02-03T05:55:16ZengWileyCanadian Journal of Gastroenterology0835-79001991-01-0152778110.1155/1991/671534Quantitative Liver Function Tests: A Realizable Goal?Denis J Morgan0Susan L Elliott1Hany Ghabrial2Richard A Smallwood3Victorian College of Pharmacy, Melbourne, AustraliaVictorian College of Pharmacy, Melbourne, AustraliaVictorian College of Pharmacy, Melbourne, AustraliaVictorian College of Pharmacy, Melbourne, AustraliaA variety of tests has been used to assess liver function and predict hepatic functional reserve in patients with liver disease. These tests comprise clinical assessment, simple biochemical measurements and so-called ‘quantitative’ tests of liver function, ie, elimination rate measurements of exogenous markers such as drugs and other compounds. So far no single test or group of tests has proved to be a sufficiently sensitive and accurate measure of overall hepatic function across the whole spectrum of liver disease. This may he due to diversity in the hepatic handling of these compounds and in changes in architecture, hemodynamics and cell function in liver disease. The absence of a satisfactory test emphasizes the value of clinical assessments (eg, the Child-Turcotte or Child-Pugh classifications), because of their relative simplicity.http://dx.doi.org/10.1155/1991/671534 |
| spellingShingle | Denis J Morgan Susan L Elliott Hany Ghabrial Richard A Smallwood Quantitative Liver Function Tests: A Realizable Goal? Canadian Journal of Gastroenterology |
| title | Quantitative Liver Function Tests: A Realizable Goal? |
| title_full | Quantitative Liver Function Tests: A Realizable Goal? |
| title_fullStr | Quantitative Liver Function Tests: A Realizable Goal? |
| title_full_unstemmed | Quantitative Liver Function Tests: A Realizable Goal? |
| title_short | Quantitative Liver Function Tests: A Realizable Goal? |
| title_sort | quantitative liver function tests a realizable goal |
| url | http://dx.doi.org/10.1155/1991/671534 |
| work_keys_str_mv | AT denisjmorgan quantitativeliverfunctiontestsarealizablegoal AT susanlelliott quantitativeliverfunctiontestsarealizablegoal AT hanyghabrial quantitativeliverfunctiontestsarealizablegoal AT richardasmallwood quantitativeliverfunctiontestsarealizablegoal |