Infusion of young donor plasma components in older patients modifies the immune and inflammatory response to surgical tissue injury: a randomized clinical trial

Infusion of young donor plasma components in older patients modifies the immune and inflammatory response to surgical tissue injury: a randomized clinical trial

Abstract Background Preclinical evidence suggests that young plasma has beneficial effects on multiple organ systems in aged mice. Whether young plasma exerts beneficial effects in an aging human population remains highly controversial. Despite lacking data, young donor plasma infusions have been pr...

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Main Authors: Brice Gaudilliere, Lei Xue, Amy S. Tsai, Xiaoxiao Gao, Tiffany N. McAllister, Martha Tingle, Gladys Porras, Igor Feinstein, Dorien Feyaerts, Franck Verdonk, Maximilian Sabayev, Julien Hedou, Edward A. Ganio, Eloïse Berson, Martin Becker, Camilo Espinosa, Yeasul Kim, Benoit Lehallier, Esther Rawner, Chunmiao Feng, Derek F. Amanatullah, James I. Huddleston, Stuart B. Goodman, Nima Aghaeepour, Martin S. Angst
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Translational Medicine
Subjects:
Aging
Elderly population
Inflammaging
Inflammation
Immune cells
Tissue injury
Online Access:https://doi.org/10.1186/s12967-025-06215-w
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