Antipseudomonal β-Lactams Resistance in Iran
Over the last years, the mortality rate of Pseudomonas aeruginosa, which is one of the major reasons for severe infections, has been significantly increasing. This bacterium is highly resistant to many antibiotics, especially carbapenems, thanks to its complicated mechanism by which it can acquire e...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | International Journal of Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2020/8818315 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551711958368256 |
|---|---|
| author | Mohammad Mahdi Rabiei Keivan Asadi Shervin Shokouhi Mohammad Javad Nasiri Ilad Alavi Darazam |
| author_facet | Mohammad Mahdi Rabiei Keivan Asadi Shervin Shokouhi Mohammad Javad Nasiri Ilad Alavi Darazam |
| author_sort | Mohammad Mahdi Rabiei |
| collection | DOAJ |
| description | Over the last years, the mortality rate of Pseudomonas aeruginosa, which is one of the major reasons for severe infections, has been significantly increasing. This bacterium is highly resistant to many antibiotics, especially carbapenems, thanks to its complicated mechanism by which it can acquire exogenous genes. The purpose of this research is to have a review of empirical studies surveying the P. aeruginosa resistance to beta-lactams in Iran in order to investigate the most reliable methods by which the incidence of P. aeruginosa infections can be decreased and controlled. We performed a systematic review of all articles published from 2008 until 2018. Studies which did not address P. aeruginosa resistance to beta-lactams were excluded from the analysis. Studies with less than 10 cases were also excluded. Studies with more than ten cases, which did not have repetitive information, were taken into account for the final selection; 133 out of 893 articles were chosen. The resistance rate of P. aeruginosa among the articles was as follows: more than 72% of studies revealed >50% level of resistance to cefepime, followed by aztreonam (53.2%), ceftazidime (61%), piperacillin/tazobactam (54.5%), meropenem (48.3%), and imipenem (42.4%). The selection of empiric antipseudomonal antibiotics is absolutely uncertain and hazardous, and the risk of clinical failure may be more among cephalosporins and piperacillin-tazobactam as well as aztreonam. The results of this study illustrate that the methods enabling clinics to identify the bacterium resistance pattern and its genetic basis and to have the opportunity of empiric therapies through access to updated local data of antimicrobial susceptibility pattern are the most effective methods. However, the widespread usage of these approaches undoubtedly needs reliable molecular and nucleic acid-based devices, which are both affordable and available. |
| format | Article |
| id | doaj-art-f5d122a0362d487c9c32df1a833d95ec |
| institution | Kabale University |
| issn | 1687-918X 1687-9198 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Microbiology |
| spelling | doaj-art-f5d122a0362d487c9c32df1a833d95ec2025-02-03T06:00:48ZengWileyInternational Journal of Microbiology1687-918X1687-91982020-01-01202010.1155/2020/88183158818315Antipseudomonal β-Lactams Resistance in IranMohammad Mahdi Rabiei0Keivan Asadi1Shervin Shokouhi2Mohammad Javad Nasiri3Ilad Alavi Darazam4Clinical Research Development Unit of Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranClinical Research Development Unit of Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranClinical Research Development Unit of Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Medical Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranClinical Research Development Unit of Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranOver the last years, the mortality rate of Pseudomonas aeruginosa, which is one of the major reasons for severe infections, has been significantly increasing. This bacterium is highly resistant to many antibiotics, especially carbapenems, thanks to its complicated mechanism by which it can acquire exogenous genes. The purpose of this research is to have a review of empirical studies surveying the P. aeruginosa resistance to beta-lactams in Iran in order to investigate the most reliable methods by which the incidence of P. aeruginosa infections can be decreased and controlled. We performed a systematic review of all articles published from 2008 until 2018. Studies which did not address P. aeruginosa resistance to beta-lactams were excluded from the analysis. Studies with less than 10 cases were also excluded. Studies with more than ten cases, which did not have repetitive information, were taken into account for the final selection; 133 out of 893 articles were chosen. The resistance rate of P. aeruginosa among the articles was as follows: more than 72% of studies revealed >50% level of resistance to cefepime, followed by aztreonam (53.2%), ceftazidime (61%), piperacillin/tazobactam (54.5%), meropenem (48.3%), and imipenem (42.4%). The selection of empiric antipseudomonal antibiotics is absolutely uncertain and hazardous, and the risk of clinical failure may be more among cephalosporins and piperacillin-tazobactam as well as aztreonam. The results of this study illustrate that the methods enabling clinics to identify the bacterium resistance pattern and its genetic basis and to have the opportunity of empiric therapies through access to updated local data of antimicrobial susceptibility pattern are the most effective methods. However, the widespread usage of these approaches undoubtedly needs reliable molecular and nucleic acid-based devices, which are both affordable and available.http://dx.doi.org/10.1155/2020/8818315 |
| spellingShingle | Mohammad Mahdi Rabiei Keivan Asadi Shervin Shokouhi Mohammad Javad Nasiri Ilad Alavi Darazam Antipseudomonal β-Lactams Resistance in Iran International Journal of Microbiology |
| title | Antipseudomonal β-Lactams Resistance in Iran |
| title_full | Antipseudomonal β-Lactams Resistance in Iran |
| title_fullStr | Antipseudomonal β-Lactams Resistance in Iran |
| title_full_unstemmed | Antipseudomonal β-Lactams Resistance in Iran |
| title_short | Antipseudomonal β-Lactams Resistance in Iran |
| title_sort | antipseudomonal β lactams resistance in iran |
| url | http://dx.doi.org/10.1155/2020/8818315 |
| work_keys_str_mv | AT mohammadmahdirabiei antipseudomonalblactamsresistanceiniran AT keivanasadi antipseudomonalblactamsresistanceiniran AT shervinshokouhi antipseudomonalblactamsresistanceiniran AT mohammadjavadnasiri antipseudomonalblactamsresistanceiniran AT iladalavidarazam antipseudomonalblactamsresistanceiniran |