MitCOM-based prognostic model identifies GLUD1 as a key suppressor of glioblastoma growth and invasion through regulation of mitochondrial structure and metabolism

MitCOM-based prognostic model identifies GLUD1 as a key suppressor of glioblastoma growth and invasion through regulation of mitochondrial structure and metabolism

Abstract Background Glioblastoma (GBM) is a highly aggressive brain tumour with a poor prognosis. Mitochondrial dysfunction, including changes in oxidative phosphorylation, reactive oxygen species (ROS) production, and cristae organisation, plays a key role in the progression of GBM. However, the ro...

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Bibliographic Details
Main Authors: Yang Li, Chaoying Qin, Liangqi Jiang, Jun Su, Zhen Li, Qing Liu, Yuanbing Yao
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cancer Cell International
Subjects:
Glioblastoma
GLUD1
MitCOM
Online Access:https://doi.org/10.1186/s12935-025-03875-y
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