Synthesis of New Oxindoles and Determination of Their Antibacterial Properties
A versatile method for the synthesis of new oxindoles was developed by the reaction between substituted isatins and 5-aminopyrazoles. The reaction was carried out at room temperature in ethanol using p-toluenesulfonic acid as the catalyst. The products were obtained with acceptable to excellent yiel...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Heteroatom Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2020/8021920 |
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| _version_ | 1832556373614788608 |
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| author | Pablo E. Romo Braulio Insuasty Rodrigo Abonia María del Pilar Crespo Jairo Quiroga |
| author_facet | Pablo E. Romo Braulio Insuasty Rodrigo Abonia María del Pilar Crespo Jairo Quiroga |
| author_sort | Pablo E. Romo |
| collection | DOAJ |
| description | A versatile method for the synthesis of new oxindoles was developed by the reaction between substituted isatins and 5-aminopyrazoles. The reaction was carried out at room temperature in ethanol using p-toluenesulfonic acid as the catalyst. The products were obtained with acceptable to excellent yields (44–96%). Structures of the new compounds were unambiguously established by spectroscopic and analytical techniques. The antibacterial activity was determined by microdilution assays. Compounds 3b, 3e, and 3g showed antistaphylococcal activity, particularly compound 3e displayed a potent activity against the vancomycin intermediate Staphylococcus aureus (VISA). Compounds 3i, 3j, and 3o inhibited Neisseria gonorrhoeae growth. |
| format | Article |
| id | doaj-art-f5ce4f26963b434695f03f8bc2b7d9e9 |
| institution | Kabale University |
| issn | 1042-7163 1098-1071 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Heteroatom Chemistry |
| spelling | doaj-art-f5ce4f26963b434695f03f8bc2b7d9e92025-02-03T05:45:45ZengWileyHeteroatom Chemistry1042-71631098-10712020-01-01202010.1155/2020/80219208021920Synthesis of New Oxindoles and Determination of Their Antibacterial PropertiesPablo E. Romo0Braulio Insuasty1Rodrigo Abonia2María del Pilar Crespo3Jairo Quiroga4Research Group of Heterocyclic Compounds (GICH), Department of Chemistry, Universidad del Valle, A. A. 25360, Cali, ColombiaResearch Group of Heterocyclic Compounds (GICH), Department of Chemistry, Universidad del Valle, A. A. 25360, Cali, ColombiaResearch Group of Heterocyclic Compounds (GICH), Department of Chemistry, Universidad del Valle, A. A. 25360, Cali, ColombiaDepartment of Microbiology, Universidad del Valle, A. A. 25360, Cali, ColombiaResearch Group of Heterocyclic Compounds (GICH), Department of Chemistry, Universidad del Valle, A. A. 25360, Cali, ColombiaA versatile method for the synthesis of new oxindoles was developed by the reaction between substituted isatins and 5-aminopyrazoles. The reaction was carried out at room temperature in ethanol using p-toluenesulfonic acid as the catalyst. The products were obtained with acceptable to excellent yields (44–96%). Structures of the new compounds were unambiguously established by spectroscopic and analytical techniques. The antibacterial activity was determined by microdilution assays. Compounds 3b, 3e, and 3g showed antistaphylococcal activity, particularly compound 3e displayed a potent activity against the vancomycin intermediate Staphylococcus aureus (VISA). Compounds 3i, 3j, and 3o inhibited Neisseria gonorrhoeae growth.http://dx.doi.org/10.1155/2020/8021920 |
| spellingShingle | Pablo E. Romo Braulio Insuasty Rodrigo Abonia María del Pilar Crespo Jairo Quiroga Synthesis of New Oxindoles and Determination of Their Antibacterial Properties Heteroatom Chemistry |
| title | Synthesis of New Oxindoles and Determination of Their Antibacterial Properties |
| title_full | Synthesis of New Oxindoles and Determination of Their Antibacterial Properties |
| title_fullStr | Synthesis of New Oxindoles and Determination of Their Antibacterial Properties |
| title_full_unstemmed | Synthesis of New Oxindoles and Determination of Their Antibacterial Properties |
| title_short | Synthesis of New Oxindoles and Determination of Their Antibacterial Properties |
| title_sort | synthesis of new oxindoles and determination of their antibacterial properties |
| url | http://dx.doi.org/10.1155/2020/8021920 |
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