Two Cases of Heavy Chain MGUS
Heavy chain diseases are rare variants of B-cell lymphomas that produce one of three classes of immunoglobulin heavy chains, without corresponding light chains. We describe two patients with asymptomatic heavy chain monoclonal gammopathy. The first patient is a 51-year-old woman with alpha paraprote...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/8749153 |
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| author | Jan Van Keer Björn Meijers Michel Delforge Gregor Verhoef Koen Poesen |
| author_facet | Jan Van Keer Björn Meijers Michel Delforge Gregor Verhoef Koen Poesen |
| author_sort | Jan Van Keer |
| collection | DOAJ |
| description | Heavy chain diseases are rare variants of B-cell lymphomas that produce one of three classes of immunoglobulin heavy chains, without corresponding light chains. We describe two patients with asymptomatic heavy chain monoclonal gammopathy. The first patient is a 51-year-old woman with alpha paraprotein on serum immunofixation. The second case is a 46-year-old woman with gamma paraprotein on urine immunofixation. Neither patient had corresponding monoclonal light chains. Workup for multiple myeloma and lymphoma was negative in both patients. These two cases illustrate that heavy chain monoclonal gammopathy can exist in the absence of clinically apparent malignancy. Only a few reports of “heavy chain MGUS” have been described before. In the absence of specialized guidelines, we suggest a similar follow-up as for MGUS, while taking into account the higher probability of progression to lymphoma than to myeloma. |
| format | Article |
| id | doaj-art-f5c0af6085d740a8befa4634138a9ada |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-f5c0af6085d740a8befa4634138a9ada2025-02-03T05:44:04ZengWileyCase Reports in Oncological Medicine2090-67062090-67142016-01-01201610.1155/2016/87491538749153Two Cases of Heavy Chain MGUSJan Van Keer0Björn Meijers1Michel Delforge2Gregor Verhoef3Koen Poesen4Nephrology, Dialysis and Renal Transplantation, University Hospitals Leuven, 3000 Leuven, BelgiumNephrology, Dialysis and Renal Transplantation, University Hospitals Leuven, 3000 Leuven, BelgiumHematology, University Hospitals Leuven, 3000 Leuven, BelgiumHematology, University Hospitals Leuven, 3000 Leuven, BelgiumLaboratory Medicine, University Hospitals Leuven, 3000 Leuven, BelgiumHeavy chain diseases are rare variants of B-cell lymphomas that produce one of three classes of immunoglobulin heavy chains, without corresponding light chains. We describe two patients with asymptomatic heavy chain monoclonal gammopathy. The first patient is a 51-year-old woman with alpha paraprotein on serum immunofixation. The second case is a 46-year-old woman with gamma paraprotein on urine immunofixation. Neither patient had corresponding monoclonal light chains. Workup for multiple myeloma and lymphoma was negative in both patients. These two cases illustrate that heavy chain monoclonal gammopathy can exist in the absence of clinically apparent malignancy. Only a few reports of “heavy chain MGUS” have been described before. In the absence of specialized guidelines, we suggest a similar follow-up as for MGUS, while taking into account the higher probability of progression to lymphoma than to myeloma.http://dx.doi.org/10.1155/2016/8749153 |
| spellingShingle | Jan Van Keer Björn Meijers Michel Delforge Gregor Verhoef Koen Poesen Two Cases of Heavy Chain MGUS Case Reports in Oncological Medicine |
| title | Two Cases of Heavy Chain MGUS |
| title_full | Two Cases of Heavy Chain MGUS |
| title_fullStr | Two Cases of Heavy Chain MGUS |
| title_full_unstemmed | Two Cases of Heavy Chain MGUS |
| title_short | Two Cases of Heavy Chain MGUS |
| title_sort | two cases of heavy chain mgus |
| url | http://dx.doi.org/10.1155/2016/8749153 |
| work_keys_str_mv | AT janvankeer twocasesofheavychainmgus AT bjornmeijers twocasesofheavychainmgus AT micheldelforge twocasesofheavychainmgus AT gregorverhoef twocasesofheavychainmgus AT koenpoesen twocasesofheavychainmgus |