Synthesis and Characterization of Iodinated Chitosan Nanoparticles and Their Effects on Cancer Cells
The high degree of chemical modification of the chitosan chains due to protonated amine groups allows them to react with many negatively charged surfaces as anionic polymers and cell membranes, resulting in an attractive material for medical and pharmaceutics applications. Incorporating ionic iodine...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2024/3850286 |
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| author | Germán Alvarado Tenorio Roberto Espinosa Neira Carlos Alberto Ávila Orta Gabriela Yolotzín Romero Zúñiga Hortensia Ortega Ortiz |
| author_facet | Germán Alvarado Tenorio Roberto Espinosa Neira Carlos Alberto Ávila Orta Gabriela Yolotzín Romero Zúñiga Hortensia Ortega Ortiz |
| author_sort | Germán Alvarado Tenorio |
| collection | DOAJ |
| description | The high degree of chemical modification of the chitosan chains due to protonated amine groups allows them to react with many negatively charged surfaces as anionic polymers and cell membranes, resulting in an attractive material for medical and pharmaceutics applications. Incorporating ionic iodine (I− and IO3−) on chitosan chains is a direct way to successfully obtain chitosan-iodine nanoparticles (CSNPs-I and CSNPs-IO3) through ionic gelation. The nanoparticles (NPs) present a hemispherical morphology with sizes around 30–70 nm for CSNPs-I and CSNPs-IO3, similar to chitosan NPs, in accordance with SEM and DLS techniques. The XRD characterization did not show noticeable differences in the crystallinity index (CI) for CSNPs and CSNPs-I, 48.4 and 49.3%, respectively, but for CSNPs-IO3, the CI decreased to 43.85%. The cytotoxic effects on human tumor cells of chitosan and iodine-modified chitosan nanoparticles (CSNPs-I and CSNPs-IO3) were evaluated for 24 h in a range from 0.15 mg/mL to 0.95 mg/mL concentrations, where CSNPs-IO3 presented the lower viability for lung cancer A549, followed by cervical cancer HeLa cell and finally breast cancer MDA-MB-231, with a weight content of iodate ion in a range of 8.7 to 15 μg. This work presents the possibility of exploring chitosan-iodine NPs in medical applications. |
| format | Article |
| id | doaj-art-f5b7cecded5d4d74a9680de70d2a4d94 |
| institution | Kabale University |
| issn | 1687-8795 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-f5b7cecded5d4d74a9680de70d2a4d942025-02-03T00:12:59ZengWileyInternational Journal of Biomaterials1687-87952024-01-01202410.1155/2024/3850286Synthesis and Characterization of Iodinated Chitosan Nanoparticles and Their Effects on Cancer CellsGermán Alvarado Tenorio0Roberto Espinosa Neira1Carlos Alberto Ávila Orta2Gabriela Yolotzín Romero Zúñiga3Hortensia Ortega Ortiz4Departamento de Materiales AvanzadosDepartamento de Materiales AvanzadosDepartamento de Materiales AvanzadosDepartamento de Materiales AvanzadosDepartamento de Materiales AvanzadosThe high degree of chemical modification of the chitosan chains due to protonated amine groups allows them to react with many negatively charged surfaces as anionic polymers and cell membranes, resulting in an attractive material for medical and pharmaceutics applications. Incorporating ionic iodine (I− and IO3−) on chitosan chains is a direct way to successfully obtain chitosan-iodine nanoparticles (CSNPs-I and CSNPs-IO3) through ionic gelation. The nanoparticles (NPs) present a hemispherical morphology with sizes around 30–70 nm for CSNPs-I and CSNPs-IO3, similar to chitosan NPs, in accordance with SEM and DLS techniques. The XRD characterization did not show noticeable differences in the crystallinity index (CI) for CSNPs and CSNPs-I, 48.4 and 49.3%, respectively, but for CSNPs-IO3, the CI decreased to 43.85%. The cytotoxic effects on human tumor cells of chitosan and iodine-modified chitosan nanoparticles (CSNPs-I and CSNPs-IO3) were evaluated for 24 h in a range from 0.15 mg/mL to 0.95 mg/mL concentrations, where CSNPs-IO3 presented the lower viability for lung cancer A549, followed by cervical cancer HeLa cell and finally breast cancer MDA-MB-231, with a weight content of iodate ion in a range of 8.7 to 15 μg. This work presents the possibility of exploring chitosan-iodine NPs in medical applications.http://dx.doi.org/10.1155/2024/3850286 |
| spellingShingle | Germán Alvarado Tenorio Roberto Espinosa Neira Carlos Alberto Ávila Orta Gabriela Yolotzín Romero Zúñiga Hortensia Ortega Ortiz Synthesis and Characterization of Iodinated Chitosan Nanoparticles and Their Effects on Cancer Cells International Journal of Biomaterials |
| title | Synthesis and Characterization of Iodinated Chitosan Nanoparticles and Their Effects on Cancer Cells |
| title_full | Synthesis and Characterization of Iodinated Chitosan Nanoparticles and Their Effects on Cancer Cells |
| title_fullStr | Synthesis and Characterization of Iodinated Chitosan Nanoparticles and Their Effects on Cancer Cells |
| title_full_unstemmed | Synthesis and Characterization of Iodinated Chitosan Nanoparticles and Their Effects on Cancer Cells |
| title_short | Synthesis and Characterization of Iodinated Chitosan Nanoparticles and Their Effects on Cancer Cells |
| title_sort | synthesis and characterization of iodinated chitosan nanoparticles and their effects on cancer cells |
| url | http://dx.doi.org/10.1155/2024/3850286 |
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