Focal Therapy for Prostate Cancer: Recent Advances and Insights
Focal therapy has emerged as a balanced middle ground aiming to reduce overtreatment and the risk of progression, as well as patients’ distress and anxiety. Focal therapy and partial gland ablation prioritize the precise elimination of the index lesion and a surrounding safety margin to optimize tre...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/32/1/15 |
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| author | Francesco Lasorsa Arianna Biasatti Angelo Orsini Gabriele Bignante Gabriana M. Farah Savio Domenico Pandolfo Luca Lambertini Deepika Reddy Rocco Damiano Pasquale Ditonno Giuseppe Lucarelli Riccardo Autorino Srinivas Vourganti |
| author_facet | Francesco Lasorsa Arianna Biasatti Angelo Orsini Gabriele Bignante Gabriana M. Farah Savio Domenico Pandolfo Luca Lambertini Deepika Reddy Rocco Damiano Pasquale Ditonno Giuseppe Lucarelli Riccardo Autorino Srinivas Vourganti |
| author_sort | Francesco Lasorsa |
| collection | DOAJ |
| description | Focal therapy has emerged as a balanced middle ground aiming to reduce overtreatment and the risk of progression, as well as patients’ distress and anxiety. Focal therapy and partial gland ablation prioritize the precise elimination of the index lesion and a surrounding safety margin to optimize treatment outcomes and lower the risk of residual disease. The paradigm of whole-gland ablation has shifted towards more targeted approaches. Several treatment templates ranging from subtotal and hemiablation to “hockey-stick”, quadrant, and even focal lesion ablation have emerged. Many types of energy may be utilized during focal treatment. First, focal therapy can be grossly classified into thermal vs. non-thermal energy. The aim of this non-systematic review is to offer a comprehensive analysis of recently available evidence on focal therapy for PCa. |
| format | Article |
| id | doaj-art-f5b43742f92e472d81b5b0061339dfc7 |
| institution | Kabale University |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj-art-f5b43742f92e472d81b5b0061339dfc72025-01-24T13:28:22ZengMDPI AGCurrent Oncology1198-00521718-77292024-12-013211510.3390/curroncol32010015Focal Therapy for Prostate Cancer: Recent Advances and InsightsFrancesco Lasorsa0Arianna Biasatti1Angelo Orsini2Gabriele Bignante3Gabriana M. Farah4Savio Domenico Pandolfo5Luca Lambertini6Deepika Reddy7Rocco Damiano8Pasquale Ditonno9Giuseppe Lucarelli10Riccardo Autorino11Srinivas Vourganti12Department of Urology, Rush University, Chicago, IL 60612, USADepartment of Urology, Rush University, Chicago, IL 60612, USADepartment of Urology, Rush University, Chicago, IL 60612, USADepartment of Urology, Rush University, Chicago, IL 60612, USADepartment of Urology, Rush University, Chicago, IL 60612, USADepartment of Urology, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Experimental and Clinical Medicine, Careggi Hospital, University of Florence, 50121 Florence, ItalyNHS Imperial College London, London W2 1NY, UKDepartment of Urology, Magna Graecia University, 88100 Catanzaro, ItalyDepartment of Precision and Regenerative Medicine and Ionian Area-Urology, Andrology and Kidney Transplantation Unit, University of Bari “Aldo Moro”, 70121 Bari, ItalyDepartment of Precision and Regenerative Medicine and Ionian Area-Urology, Andrology and Kidney Transplantation Unit, University of Bari “Aldo Moro”, 70121 Bari, ItalyDepartment of Urology, Rush University, Chicago, IL 60612, USADepartment of Urology, Rush University, Chicago, IL 60612, USAFocal therapy has emerged as a balanced middle ground aiming to reduce overtreatment and the risk of progression, as well as patients’ distress and anxiety. Focal therapy and partial gland ablation prioritize the precise elimination of the index lesion and a surrounding safety margin to optimize treatment outcomes and lower the risk of residual disease. The paradigm of whole-gland ablation has shifted towards more targeted approaches. Several treatment templates ranging from subtotal and hemiablation to “hockey-stick”, quadrant, and even focal lesion ablation have emerged. Many types of energy may be utilized during focal treatment. First, focal therapy can be grossly classified into thermal vs. non-thermal energy. The aim of this non-systematic review is to offer a comprehensive analysis of recently available evidence on focal therapy for PCa.https://www.mdpi.com/1718-7729/32/1/15prostate cancerfocal therapyablation |
| spellingShingle | Francesco Lasorsa Arianna Biasatti Angelo Orsini Gabriele Bignante Gabriana M. Farah Savio Domenico Pandolfo Luca Lambertini Deepika Reddy Rocco Damiano Pasquale Ditonno Giuseppe Lucarelli Riccardo Autorino Srinivas Vourganti Focal Therapy for Prostate Cancer: Recent Advances and Insights Current Oncology prostate cancer focal therapy ablation |
| title | Focal Therapy for Prostate Cancer: Recent Advances and Insights |
| title_full | Focal Therapy for Prostate Cancer: Recent Advances and Insights |
| title_fullStr | Focal Therapy for Prostate Cancer: Recent Advances and Insights |
| title_full_unstemmed | Focal Therapy for Prostate Cancer: Recent Advances and Insights |
| title_short | Focal Therapy for Prostate Cancer: Recent Advances and Insights |
| title_sort | focal therapy for prostate cancer recent advances and insights |
| topic | prostate cancer focal therapy ablation |
| url | https://www.mdpi.com/1718-7729/32/1/15 |
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