Functional Localization of Adult-Onset Idiopathic Nesidioblastosis
Nesidioblastosis is a rare pancreatic disorder involving enlarged beta cells throughout the pancreas, causing elevated insulin production. We present the case of a 53-year-old woman with the initial symptom of fasting hypoglycemia. No pancreatic lesions were indicated on computed tomography and magn...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2022/2802975 |
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| author | Jess C. Hercus Pouneh Pasha Sadiq Al Lawati Peter Kim Andre Mattman Douglas Webber David M. Thompson |
| author_facet | Jess C. Hercus Pouneh Pasha Sadiq Al Lawati Peter Kim Andre Mattman Douglas Webber David M. Thompson |
| author_sort | Jess C. Hercus |
| collection | DOAJ |
| description | Nesidioblastosis is a rare pancreatic disorder involving enlarged beta cells throughout the pancreas, causing elevated insulin production. We present the case of a 53-year-old woman with the initial symptom of fasting hypoglycemia. No pancreatic lesions were indicated on computed tomography and magnetic resonance imaging scans, and an octreotide scan was negative for insulinoma. Selective arterial calcium stimulation (SACST) showed increased insulin production from the stimulation of 3 out of 5 arteries. The SACST results suggested a diagnosis of nesidioblastosis, which was confirmed by histopathology after a subtotal distal pancreatectomy. The patient has normal glucose tolerance after surgery with no further problems of hypoglycemia, indicating that this is a rare case of nesidioblastosis extending only partially through the pancreas. |
| format | Article |
| id | doaj-art-f5b2a25216b0462c850e88fb8d565b5c |
| institution | Kabale University |
| issn | 2090-651X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-f5b2a25216b0462c850e88fb8d565b5c2025-02-03T06:12:57ZengWileyCase Reports in Endocrinology2090-651X2022-01-01202210.1155/2022/2802975Functional Localization of Adult-Onset Idiopathic NesidioblastosisJess C. Hercus0Pouneh Pasha1Sadiq Al Lawati2Peter Kim3Andre Mattman4Douglas Webber5David M. Thompson6Department of Biological SciencesDivision of Internal MedicineDivision of EndocrinologyDivision of General SurgeryDivision of Pathology and Laboratory MedicineDivision of Pathology and Laboratory MedicineDivision of EndocrinologyNesidioblastosis is a rare pancreatic disorder involving enlarged beta cells throughout the pancreas, causing elevated insulin production. We present the case of a 53-year-old woman with the initial symptom of fasting hypoglycemia. No pancreatic lesions were indicated on computed tomography and magnetic resonance imaging scans, and an octreotide scan was negative for insulinoma. Selective arterial calcium stimulation (SACST) showed increased insulin production from the stimulation of 3 out of 5 arteries. The SACST results suggested a diagnosis of nesidioblastosis, which was confirmed by histopathology after a subtotal distal pancreatectomy. The patient has normal glucose tolerance after surgery with no further problems of hypoglycemia, indicating that this is a rare case of nesidioblastosis extending only partially through the pancreas.http://dx.doi.org/10.1155/2022/2802975 |
| spellingShingle | Jess C. Hercus Pouneh Pasha Sadiq Al Lawati Peter Kim Andre Mattman Douglas Webber David M. Thompson Functional Localization of Adult-Onset Idiopathic Nesidioblastosis Case Reports in Endocrinology |
| title | Functional Localization of Adult-Onset Idiopathic Nesidioblastosis |
| title_full | Functional Localization of Adult-Onset Idiopathic Nesidioblastosis |
| title_fullStr | Functional Localization of Adult-Onset Idiopathic Nesidioblastosis |
| title_full_unstemmed | Functional Localization of Adult-Onset Idiopathic Nesidioblastosis |
| title_short | Functional Localization of Adult-Onset Idiopathic Nesidioblastosis |
| title_sort | functional localization of adult onset idiopathic nesidioblastosis |
| url | http://dx.doi.org/10.1155/2022/2802975 |
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