Synthesis and Biological Evaluation of Mannich Bases of Isoxazoline Derivatives as Novel Anti-Microbial Agents
A novel series of compounds were synthesized by condensation reaction of substituted acetophenone (1a-b) with substituted aldehyde (2a-b) in presence of alcoholic sodium hydroxide to get intermediate chalcones (3a-c), which were further treated with hydroxylamine hydrochloride in presence of sodium...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2012/386428 |
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| author | Pawar Sudhir Chavan Rajashree Bhosale Ashok |
| author_facet | Pawar Sudhir Chavan Rajashree Bhosale Ashok |
| author_sort | Pawar Sudhir |
| collection | DOAJ |
| description | A novel series of compounds were synthesized by condensation reaction of substituted acetophenone (1a-b) with substituted aldehyde (2a-b) in presence of alcoholic sodium hydroxide to get intermediate chalcones (3a-c), which were further treated with hydroxylamine hydrochloride in presence of sodium hydroxide to get isoxazolines derivatives (4a-c). The latter were refluxed with substituted primary amines and formaldehyde for 6-10 h to afford Mannich bases. The synthesized compounds were characterized on the basis of their spectral (IR, 1HNMR) data and evaluated for the antimicrobial activity by using Zone of Inhibition by cup plate method and Minimum Inhibitory Concentration by broth dilution method. |
| format | Article |
| id | doaj-art-f5a8a24f97954c8f8d23d43a2d99ce0f |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-f5a8a24f97954c8f8d23d43a2d99ce0f2025-02-03T01:21:35ZengWileyE-Journal of Chemistry0973-49452090-98102012-01-01941760177210.1155/2012/386428Synthesis and Biological Evaluation of Mannich Bases of Isoxazoline Derivatives as Novel Anti-Microbial AgentsPawar Sudhir0Chavan Rajashree1Bhosale Ashok2Department of Pharmaceutical Chemistry, PDEA's Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune-412 301, IndiaDepartment of Pharmaceutical Chemistry, PDEA's Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune-412 301, IndiaDepartment of Pharmaceutical Chemistry, PDEA's Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune-412 301, IndiaA novel series of compounds were synthesized by condensation reaction of substituted acetophenone (1a-b) with substituted aldehyde (2a-b) in presence of alcoholic sodium hydroxide to get intermediate chalcones (3a-c), which were further treated with hydroxylamine hydrochloride in presence of sodium hydroxide to get isoxazolines derivatives (4a-c). The latter were refluxed with substituted primary amines and formaldehyde for 6-10 h to afford Mannich bases. The synthesized compounds were characterized on the basis of their spectral (IR, 1HNMR) data and evaluated for the antimicrobial activity by using Zone of Inhibition by cup plate method and Minimum Inhibitory Concentration by broth dilution method.http://dx.doi.org/10.1155/2012/386428 |
| spellingShingle | Pawar Sudhir Chavan Rajashree Bhosale Ashok Synthesis and Biological Evaluation of Mannich Bases of Isoxazoline Derivatives as Novel Anti-Microbial Agents E-Journal of Chemistry |
| title | Synthesis and Biological Evaluation of Mannich Bases of Isoxazoline Derivatives as Novel Anti-Microbial Agents |
| title_full | Synthesis and Biological Evaluation of Mannich Bases of Isoxazoline Derivatives as Novel Anti-Microbial Agents |
| title_fullStr | Synthesis and Biological Evaluation of Mannich Bases of Isoxazoline Derivatives as Novel Anti-Microbial Agents |
| title_full_unstemmed | Synthesis and Biological Evaluation of Mannich Bases of Isoxazoline Derivatives as Novel Anti-Microbial Agents |
| title_short | Synthesis and Biological Evaluation of Mannich Bases of Isoxazoline Derivatives as Novel Anti-Microbial Agents |
| title_sort | synthesis and biological evaluation of mannich bases of isoxazoline derivatives as novel anti microbial agents |
| url | http://dx.doi.org/10.1155/2012/386428 |
| work_keys_str_mv | AT pawarsudhir synthesisandbiologicalevaluationofmannichbasesofisoxazolinederivativesasnovelantimicrobialagents AT chavanrajashree synthesisandbiologicalevaluationofmannichbasesofisoxazolinederivativesasnovelantimicrobialagents AT bhosaleashok synthesisandbiologicalevaluationofmannichbasesofisoxazolinederivativesasnovelantimicrobialagents |