Immune Microenvironment in Colorectal Cancer: A New Hallmark to Change Old Paradigms
Impact of immune microenvironment in prognosis of solid tumors has been extensively studied in the last few years. Specifically in colorectal carcinoma, increased knowledge of the immune events around these tumors and their relation with clinical outcomes have led to consider immune microenvironment...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/174149 |
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| _version_ | 1832567274988371968 |
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| author | Luis de la Cruz-Merino Fernando Henao Carrasco David Vicente Baz Esteban Nogales Fernández Juan José Reina Zoilo Manuel Codes Manuel de Villena Enrique Grande Pulido |
| author_facet | Luis de la Cruz-Merino Fernando Henao Carrasco David Vicente Baz Esteban Nogales Fernández Juan José Reina Zoilo Manuel Codes Manuel de Villena Enrique Grande Pulido |
| author_sort | Luis de la Cruz-Merino |
| collection | DOAJ |
| description | Impact of immune microenvironment in prognosis of solid tumors has been extensively studied in the last few years. Specifically in colorectal carcinoma, increased knowledge of the immune events around these tumors and their relation with clinical outcomes have led to consider immune microenvironment as one of the most important prognostic factors in this disease. In this review we will summarize and update the current knowledge with respect to this intriguing and complex new hallmark of cancer, paying special attention to infiltration by T-infiltrating lymphocytes and their subtypes in colorectal cancer, as well as its eventual clinical translation in terms of long-term prognosis. Finally, we suggest some possible investigational approaches based on combinatorial strategies to trigger and boost immune reaction against tumor cells. |
| format | Article |
| id | doaj-art-f5a64aa4e97645fa901d4eb4934340bc |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-f5a64aa4e97645fa901d4eb4934340bc2025-02-03T01:01:56ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/174149174149Immune Microenvironment in Colorectal Cancer: A New Hallmark to Change Old ParadigmsLuis de la Cruz-Merino0Fernando Henao Carrasco1David Vicente Baz2Esteban Nogales Fernández3Juan José Reina Zoilo4Manuel Codes Manuel de Villena5Enrique Grande Pulido6Clinical Oncology Department, Hospital Universitario Virgen Macarena, Avenida Dr. Fedriani s/n, 41009 Sevilla, SpainClinical Oncology Department, Hospital Universitario Virgen Macarena, Avenida Dr. Fedriani s/n, 41009 Sevilla, SpainClinical Oncology Department, Hospital Universitario Virgen Macarena, Avenida Dr. Fedriani s/n, 41009 Sevilla, SpainClinical Oncology Department, Hospital Universitario Virgen Macarena, Avenida Dr. Fedriani s/n, 41009 Sevilla, SpainClinical Oncology Department, Hospital Universitario Virgen Macarena, Avenida Dr. Fedriani s/n, 41009 Sevilla, SpainClinical Oncology Department, Hospital Universitario Virgen Macarena, Avenida Dr. Fedriani s/n, 41009 Sevilla, SpainClinical Oncology Department, Hospital Universitario Ramón y Cajal, Carretera de Colmenar Viejo, Km 9,100, 28034 Madrid, SpainImpact of immune microenvironment in prognosis of solid tumors has been extensively studied in the last few years. Specifically in colorectal carcinoma, increased knowledge of the immune events around these tumors and their relation with clinical outcomes have led to consider immune microenvironment as one of the most important prognostic factors in this disease. In this review we will summarize and update the current knowledge with respect to this intriguing and complex new hallmark of cancer, paying special attention to infiltration by T-infiltrating lymphocytes and their subtypes in colorectal cancer, as well as its eventual clinical translation in terms of long-term prognosis. Finally, we suggest some possible investigational approaches based on combinatorial strategies to trigger and boost immune reaction against tumor cells.http://dx.doi.org/10.1155/2011/174149 |
| spellingShingle | Luis de la Cruz-Merino Fernando Henao Carrasco David Vicente Baz Esteban Nogales Fernández Juan José Reina Zoilo Manuel Codes Manuel de Villena Enrique Grande Pulido Immune Microenvironment in Colorectal Cancer: A New Hallmark to Change Old Paradigms Clinical and Developmental Immunology |
| title | Immune Microenvironment in Colorectal Cancer: A New Hallmark to Change Old Paradigms |
| title_full | Immune Microenvironment in Colorectal Cancer: A New Hallmark to Change Old Paradigms |
| title_fullStr | Immune Microenvironment in Colorectal Cancer: A New Hallmark to Change Old Paradigms |
| title_full_unstemmed | Immune Microenvironment in Colorectal Cancer: A New Hallmark to Change Old Paradigms |
| title_short | Immune Microenvironment in Colorectal Cancer: A New Hallmark to Change Old Paradigms |
| title_sort | immune microenvironment in colorectal cancer a new hallmark to change old paradigms |
| url | http://dx.doi.org/10.1155/2011/174149 |
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