Application of Autofluorescence Endoscopy for Colorectal Cancer Screening: Rationale and an Update
As the result of basic researches, several intravital fluorophores have been determined so far in human colorectal tissue. Autofluorescence endoscopy (AFE) can detect slight alterations in their distribution and concentration during the colorectal carcinogenesis process and, thus facilitate noninvas...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/971383 |
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| author | Hiroyuki Aihara Hisao Tajiri Takeshi Suzuki |
| author_facet | Hiroyuki Aihara Hisao Tajiri Takeshi Suzuki |
| author_sort | Hiroyuki Aihara |
| collection | DOAJ |
| description | As the result of basic researches, several intravital fluorophores have been determined so far in human colorectal tissue. Autofluorescence endoscopy (AFE) can detect slight alterations in their distribution and concentration during the colorectal carcinogenesis process and, thus facilitate noninvasive screening colonoscopies without the need for fluorescent substances or staining reagents to be administered. While detecting faint autofluorescence intensity by conventional fiberoptic endoscopy remains challenging, the latest AFE system with high-resolution videoendoscope capabilities enables such detection by using a false-color display algorithm. To this end, the diagnostic benefits of AFE have been reported in several multicenter randomized controlled studies of colorectal cancer (CRC) screening and differential diagnosis. CRC screening using the latest AFE technology could, therefore, lead to future reductions in CRC mortality. |
| format | Article |
| id | doaj-art-f5a5839beb0b411298827bf5764239b3 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-f5a5839beb0b411298827bf5764239b32025-02-03T00:59:56ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/971383971383Application of Autofluorescence Endoscopy for Colorectal Cancer Screening: Rationale and an UpdateHiroyuki Aihara0Hisao Tajiri1Takeshi Suzuki2Department of Endoscopy, The Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, Minato-ku, Tokyo 105-8461, JapanDepartment of Endoscopy, The Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, Minato-ku, Tokyo 105-8461, JapanDepartment of Endoscopy, The Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, Minato-ku, Tokyo 105-8461, JapanAs the result of basic researches, several intravital fluorophores have been determined so far in human colorectal tissue. Autofluorescence endoscopy (AFE) can detect slight alterations in their distribution and concentration during the colorectal carcinogenesis process and, thus facilitate noninvasive screening colonoscopies without the need for fluorescent substances or staining reagents to be administered. While detecting faint autofluorescence intensity by conventional fiberoptic endoscopy remains challenging, the latest AFE system with high-resolution videoendoscope capabilities enables such detection by using a false-color display algorithm. To this end, the diagnostic benefits of AFE have been reported in several multicenter randomized controlled studies of colorectal cancer (CRC) screening and differential diagnosis. CRC screening using the latest AFE technology could, therefore, lead to future reductions in CRC mortality.http://dx.doi.org/10.1155/2012/971383 |
| spellingShingle | Hiroyuki Aihara Hisao Tajiri Takeshi Suzuki Application of Autofluorescence Endoscopy for Colorectal Cancer Screening: Rationale and an Update Gastroenterology Research and Practice |
| title | Application of Autofluorescence Endoscopy for Colorectal Cancer Screening: Rationale and an Update |
| title_full | Application of Autofluorescence Endoscopy for Colorectal Cancer Screening: Rationale and an Update |
| title_fullStr | Application of Autofluorescence Endoscopy for Colorectal Cancer Screening: Rationale and an Update |
| title_full_unstemmed | Application of Autofluorescence Endoscopy for Colorectal Cancer Screening: Rationale and an Update |
| title_short | Application of Autofluorescence Endoscopy for Colorectal Cancer Screening: Rationale and an Update |
| title_sort | application of autofluorescence endoscopy for colorectal cancer screening rationale and an update |
| url | http://dx.doi.org/10.1155/2012/971383 |
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