AAV6 vectors provide superior gene transfer compared to AAV9 vectors following intramyocardial administration

AAV6 vectors provide superior gene transfer compared to AAV9 vectors following intramyocardial administration

Cardiac gene therapy using adeno-associated viral (AAV) vectors holds great promise for treating heart diseases but would benefit from more potent AAV vectors. Vectors based on the AAV serotypes 6 and 9 have been used in pre-clinical gene therapy studies, yet the therapeutic outcomes varied dependin...

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Main Authors: Jianan Wang, Timo Jonker, Aina Cervera-Barea, Zhenyu Dong, Ruud N. Visser, Evelien E. Birza, Arie R. Boender, Mischa Klerk, Yuting Yang, Joyce Visser, Marlijn S. Jansen, Tom C. Grootswagers, Cindy I. Bart, Saskia C.A. de Jager, Silke Schrödel, Christian Thirion, Osne F. Kirzner, Hanno L. Tan, Antoine A.F. de Vries, Joost P.G. Sluijter, Klaus Neef, Joris R. de Groot, Vincent M. Christoffels, Gerard J.J. Boink
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
cardiac gene transfer
AAV vector
intramyocardial injection
gene therapy
transduction efficiency
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050125001275
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