Maternal obesity impairs fetal brown adipogenesis by attenuating fetal FGF21 signaling

Maternal obesity impairs fetal brown adipogenesis by attenuating fetal FGF21 signaling

Summary: In mammals, maternal obesity typically impairs brown adipose tissue (BAT) formation in fetuses, increasing their risk of metabolic disorders in adulthood. However, the mechanisms behind this phenomenon are not well understood. Our single-nucleus transcriptomic analysis revealed dynamic chan...

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Main Authors: Lun Hua, Wenxue Shen, Dengfeng Gao, Yi Yang, Xiaohan Yang, Haoqi Zhang, Siyuan Liu, Luting Liu, Yaxue Cao, Xuemei Jiang, Xingfa Han, Chao Jin, Bin Feng, Lianqiang Che, Shengyu Xu, Yan Lin, Jian Li, Zhengfeng Fang, Ting Luo, Mingzhou Li, De Wu, Yong Zhuo
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Cell Reports
Subjects:
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725007065
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