Association between SPISE and NAFLD in patients with type 2 diabetes
AimsNon-alcoholic fatty liver disease (NAFLD) is closely related to type 2 diabetes (T2D), with reduced insulin sensitivity being a key factor in their disrupted metabolic processes. The single point insulin sensitivity estimator (SPISE) is a novel index. This study aims to explore the association b...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1454938/full |
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| author | Hongyan Zhao Hongyan Zhao Baolan Ji Xin Wang Shuwei Shi Shuwei Shi Jie Sheng Jie Sheng Xuan Ma Xuan Ma Bo Ban Guanqi Gao |
| author_facet | Hongyan Zhao Hongyan Zhao Baolan Ji Xin Wang Shuwei Shi Shuwei Shi Jie Sheng Jie Sheng Xuan Ma Xuan Ma Bo Ban Guanqi Gao |
| author_sort | Hongyan Zhao |
| collection | DOAJ |
| description | AimsNon-alcoholic fatty liver disease (NAFLD) is closely related to type 2 diabetes (T2D), with reduced insulin sensitivity being a key factor in their disrupted metabolic processes. The single point insulin sensitivity estimator (SPISE) is a novel index. This study aims to explore the association between SPISE and NAFLD in T2D population.MethodsThis study included a total of 2,459 patients with T2D. SPISE was calculated based on high density lipoprotein-cholesterol (HDL-c), triglycerides (TG), and body mass index (BMI). Participants were categorized into NAFLD and non-NAFLD groups based on the results of ultrasonographic diagnosis. The relationship between SPISE and NAFLD was analyzed separately for each gender.ResultsThe overall prevalence of NAFLD is 38.5%. In females and males, the SPISE was significantly reduced in the NAFLD group compared to the non-NAFLD group (both P < 0.05). The prevalence of NAFLD showed a significant reduction across quartiles of the SPISE in both genders (both P < 0.05).Additionally, univariate correlation analysis showed a negative correlation between SPISE and NAFLD (both P < 0.05). In multivariate regression analysis, a reduced SPISE was identified as an independent risk factor for NAFLD (odds ratios of 0.572 and 0.737, 95% CI of 0.477–0.687 and 0.587–0.926, respectively).Moreover, the area under the receiver operating characteristic (ROC) curve for SPISE was 0.209 in females and 0.268 in males (95% CI of 0.175–0.244 and 0.216–0.320, respectively). These results are more meaningful than those of other variables.ConclusionSPISE is significantly reduced in NAFLD patients with T2D. Compared to other indicators, SPISE demonstrates superior predictive value in diagnosing NAFLD, and it is independent of gender. |
| format | Article |
| id | doaj-art-f593db5f01454a93864df49455d30653 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-f593db5f01454a93864df49455d306532025-01-22T07:12:15ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011210.3389/fmed.2025.14549381454938Association between SPISE and NAFLD in patients with type 2 diabetesHongyan Zhao0Hongyan Zhao1Baolan Ji2Xin Wang3Shuwei Shi4Shuwei Shi5Jie Sheng6Jie Sheng7Xuan Ma8Xuan Ma9Bo Ban10Guanqi Gao11School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, ChinaDepartment of Endocrinology, Linyi People’s Hospital Affiliated to Shandong Second Medical University, Linyi, Shandong, ChinaDepartment of Endocrinology, Linyi People’s Hospital Affiliated to Shandong Second Medical University, Linyi, Shandong, ChinaSchool of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, ChinaSchool of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, ChinaDepartment of Endocrinology, Linyi People’s Hospital Affiliated to Shandong Second Medical University, Linyi, Shandong, ChinaSchool of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, ChinaDepartment of Endocrinology, Linyi People’s Hospital Affiliated to Shandong Second Medical University, Linyi, Shandong, ChinaSchool of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, ChinaDepartment of Endocrinology, Linyi People’s Hospital Affiliated to Shandong Second Medical University, Linyi, Shandong, ChinaDepartment of Endocrinology, Affiliated Hospital of Jining Medical University, Jining, Shandong, ChinaDepartment of Endocrinology, Linyi People’s Hospital Affiliated to Shandong Second Medical University, Linyi, Shandong, ChinaAimsNon-alcoholic fatty liver disease (NAFLD) is closely related to type 2 diabetes (T2D), with reduced insulin sensitivity being a key factor in their disrupted metabolic processes. The single point insulin sensitivity estimator (SPISE) is a novel index. This study aims to explore the association between SPISE and NAFLD in T2D population.MethodsThis study included a total of 2,459 patients with T2D. SPISE was calculated based on high density lipoprotein-cholesterol (HDL-c), triglycerides (TG), and body mass index (BMI). Participants were categorized into NAFLD and non-NAFLD groups based on the results of ultrasonographic diagnosis. The relationship between SPISE and NAFLD was analyzed separately for each gender.ResultsThe overall prevalence of NAFLD is 38.5%. In females and males, the SPISE was significantly reduced in the NAFLD group compared to the non-NAFLD group (both P < 0.05). The prevalence of NAFLD showed a significant reduction across quartiles of the SPISE in both genders (both P < 0.05).Additionally, univariate correlation analysis showed a negative correlation between SPISE and NAFLD (both P < 0.05). In multivariate regression analysis, a reduced SPISE was identified as an independent risk factor for NAFLD (odds ratios of 0.572 and 0.737, 95% CI of 0.477–0.687 and 0.587–0.926, respectively).Moreover, the area under the receiver operating characteristic (ROC) curve for SPISE was 0.209 in females and 0.268 in males (95% CI of 0.175–0.244 and 0.216–0.320, respectively). These results are more meaningful than those of other variables.ConclusionSPISE is significantly reduced in NAFLD patients with T2D. Compared to other indicators, SPISE demonstrates superior predictive value in diagnosing NAFLD, and it is independent of gender.https://www.frontiersin.org/articles/10.3389/fmed.2025.1454938/fulltype 2 diabetesSPISENAFLDinsulin sensitivityinsulin resistance |
| spellingShingle | Hongyan Zhao Hongyan Zhao Baolan Ji Xin Wang Shuwei Shi Shuwei Shi Jie Sheng Jie Sheng Xuan Ma Xuan Ma Bo Ban Guanqi Gao Association between SPISE and NAFLD in patients with type 2 diabetes Frontiers in Medicine type 2 diabetes SPISE NAFLD insulin sensitivity insulin resistance |
| title | Association between SPISE and NAFLD in patients with type 2 diabetes |
| title_full | Association between SPISE and NAFLD in patients with type 2 diabetes |
| title_fullStr | Association between SPISE and NAFLD in patients with type 2 diabetes |
| title_full_unstemmed | Association between SPISE and NAFLD in patients with type 2 diabetes |
| title_short | Association between SPISE and NAFLD in patients with type 2 diabetes |
| title_sort | association between spise and nafld in patients with type 2 diabetes |
| topic | type 2 diabetes SPISE NAFLD insulin sensitivity insulin resistance |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1454938/full |
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