Multimodal abnormalities of brain function in chronic low back pain: a systematic review and meta-analysis of neuroimaging studies
ObjectivesNeuroimaging investigations into chronic low back pain (CLBP) have detected functional abnormalities across a spectrum of brain regions, yet the findings have often been inconsistent. In this meta-analysis, we integrated the existing data, delineating a pattern of coherent results from the...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2025.1535288/full |
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| author | Xingyao Chen Xingyao Chen Xingyao Chen Nuo Chen Nuo Chen Nuo Chen Peng Lai Peng Lai Yiqi Sun Jie Yu Ming Xin Deliang Zhu Fanrong Liang Fanrong Liang Fanrong Liang Qian Song Shirui Cheng Shirui Cheng Shirui Cheng Zhengjie Li Zhengjie Li Zhengjie Li Zhengjie Li |
| author_facet | Xingyao Chen Xingyao Chen Xingyao Chen Nuo Chen Nuo Chen Nuo Chen Peng Lai Peng Lai Yiqi Sun Jie Yu Ming Xin Deliang Zhu Fanrong Liang Fanrong Liang Fanrong Liang Qian Song Shirui Cheng Shirui Cheng Shirui Cheng Zhengjie Li Zhengjie Li Zhengjie Li Zhengjie Li |
| author_sort | Xingyao Chen |
| collection | DOAJ |
| description | ObjectivesNeuroimaging investigations into chronic low back pain (CLBP) have detected functional abnormalities across a spectrum of brain regions, yet the findings have often been inconsistent. In this meta-analysis, we integrated the existing data, delineating a pattern of coherent results from the encompassed studies.MethodsA systematic search of neuroimaging studies investigating the brain activity differences between CLBP and Healthy controls (HCs) was conducted in seven databases up to December 22, 2024. An anisotropic effect-size signed differential mapping (AES-SDM)-based meta-analysis was carried out to report the results and perform a multimodal analysis.ResultsA total of 20 publications reporting on 24 experiments in this meta-analysis. The ReHo meta-analysis showed abnormal spontaneous activity of left inferior temporal gyrus (ITG), left superior frontal gyrus (SFG), right middle frontal gyrus (MFG), right precuneus, right fusiform gyrus and bilateral postcentral gyrus (PoCG) in CLBP patients. The ALFF meta-analysis demonstrated functional alterations in the right rolandic operculum (extending to the right insula and right IFG), left ITG, left middle occipital gyrus (MOG), left paracentral lobule, left PoCG and bilateral cuneus cortex in CLBP patients. The results of the functional group meta-analysis revealed that patients with CLBP displayed new decreased functional activity in the right thalamus, right precentral gyrus (PreCG) and right lingual gyrus.ConclusionPatients with CLBP exhibit extensive multimodal functional neuroimaging abnormalities, involving brain regions related to pain perception, emotional processing, cognitive functions, and both the visual and motor cortices. These meta-analysis findings might provide a valuable reference for the identification of potential therapeutic targets for CLBP in the brain. |
| format | Article |
| id | doaj-art-f57e401efcc04042b5b1b275c5d1dc7c |
| institution | Kabale University |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj-art-f57e401efcc04042b5b1b275c5d1dc7c2025-02-05T07:32:59ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-02-011910.3389/fnins.2025.15352881535288Multimodal abnormalities of brain function in chronic low back pain: a systematic review and meta-analysis of neuroimaging studiesXingyao Chen0Xingyao Chen1Xingyao Chen2Nuo Chen3Nuo Chen4Nuo Chen5Peng Lai6Peng Lai7Yiqi Sun8Jie Yu9Ming Xin10Deliang Zhu11Fanrong Liang12Fanrong Liang13Fanrong Liang14Qian Song15Shirui Cheng16Shirui Cheng17Shirui Cheng18Zhengjie Li19Zhengjie Li20Zhengjie Li21Zhengjie Li22The Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaAcupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaThe Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaAcupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaThe Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaAcupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaThe Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Traditional Chinese Medicine, Chengdu Fifth People’s Hospital (The Second Clinical Medical College, Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine), Geriatric Diseases Institute of Chengdu/Cancer Prevention and Treatment Institute of Chengdu, Chengdu, ChinaDepartment of Rehabilitation, Chengdu Fifth People’s Hospital (The Second Clinical Medical College, Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine), Geriatric Diseases Institute of Chengdu/Cancer Prevention and Treatment Institute of Chengdu, Chengdu, ChinaDepartment of Rehabilitation, Chengdu Fifth People’s Hospital (The Second Clinical Medical College, Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine), Geriatric Diseases Institute of Chengdu/Cancer Prevention and Treatment Institute of Chengdu, Chengdu, ChinaThe Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaAcupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaKey Laboratory of Acupuncture for Senile Disease (Chengdu University of TCM), Ministry of Education, Chengdu, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaThe Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaAcupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaKey Laboratory of Acupuncture for Senile Disease (Chengdu University of TCM), Ministry of Education, Chengdu, ChinaThe Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaAcupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaKey Laboratory of Acupuncture for Senile Disease (Chengdu University of TCM), Ministry of Education, Chengdu, ChinaObjectivesNeuroimaging investigations into chronic low back pain (CLBP) have detected functional abnormalities across a spectrum of brain regions, yet the findings have often been inconsistent. In this meta-analysis, we integrated the existing data, delineating a pattern of coherent results from the encompassed studies.MethodsA systematic search of neuroimaging studies investigating the brain activity differences between CLBP and Healthy controls (HCs) was conducted in seven databases up to December 22, 2024. An anisotropic effect-size signed differential mapping (AES-SDM)-based meta-analysis was carried out to report the results and perform a multimodal analysis.ResultsA total of 20 publications reporting on 24 experiments in this meta-analysis. The ReHo meta-analysis showed abnormal spontaneous activity of left inferior temporal gyrus (ITG), left superior frontal gyrus (SFG), right middle frontal gyrus (MFG), right precuneus, right fusiform gyrus and bilateral postcentral gyrus (PoCG) in CLBP patients. The ALFF meta-analysis demonstrated functional alterations in the right rolandic operculum (extending to the right insula and right IFG), left ITG, left middle occipital gyrus (MOG), left paracentral lobule, left PoCG and bilateral cuneus cortex in CLBP patients. The results of the functional group meta-analysis revealed that patients with CLBP displayed new decreased functional activity in the right thalamus, right precentral gyrus (PreCG) and right lingual gyrus.ConclusionPatients with CLBP exhibit extensive multimodal functional neuroimaging abnormalities, involving brain regions related to pain perception, emotional processing, cognitive functions, and both the visual and motor cortices. These meta-analysis findings might provide a valuable reference for the identification of potential therapeutic targets for CLBP in the brain.https://www.frontiersin.org/articles/10.3389/fnins.2025.1535288/fullchronic low back painfunctional magnetic resonance imagingspontaneous brain activitymeta-analysisresting-state |
| spellingShingle | Xingyao Chen Xingyao Chen Xingyao Chen Nuo Chen Nuo Chen Nuo Chen Peng Lai Peng Lai Yiqi Sun Jie Yu Ming Xin Deliang Zhu Fanrong Liang Fanrong Liang Fanrong Liang Qian Song Shirui Cheng Shirui Cheng Shirui Cheng Zhengjie Li Zhengjie Li Zhengjie Li Zhengjie Li Multimodal abnormalities of brain function in chronic low back pain: a systematic review and meta-analysis of neuroimaging studies Frontiers in Neuroscience chronic low back pain functional magnetic resonance imaging spontaneous brain activity meta-analysis resting-state |
| title | Multimodal abnormalities of brain function in chronic low back pain: a systematic review and meta-analysis of neuroimaging studies |
| title_full | Multimodal abnormalities of brain function in chronic low back pain: a systematic review and meta-analysis of neuroimaging studies |
| title_fullStr | Multimodal abnormalities of brain function in chronic low back pain: a systematic review and meta-analysis of neuroimaging studies |
| title_full_unstemmed | Multimodal abnormalities of brain function in chronic low back pain: a systematic review and meta-analysis of neuroimaging studies |
| title_short | Multimodal abnormalities of brain function in chronic low back pain: a systematic review and meta-analysis of neuroimaging studies |
| title_sort | multimodal abnormalities of brain function in chronic low back pain a systematic review and meta analysis of neuroimaging studies |
| topic | chronic low back pain functional magnetic resonance imaging spontaneous brain activity meta-analysis resting-state |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2025.1535288/full |
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